Phosphofructokinase-1, Muscle Type
"Phosphofructokinase-1, Muscle Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-1,6-bisphosphate. In humans, PHOSPHOFRUCTOKINASE-1 in muscle exists as the homotetramer of M subunits. Defects in this muscle enzyme cause GLYCOGEN STORAGE DISEASE TYPE VII, also known as Tarui's disease.
MeSH Number(s)
D08.811.913.696.620.225.850.500.500
Below are MeSH descriptors whose meaning is more general than "Phosphofructokinase-1, Muscle Type".
Below are MeSH descriptors whose meaning is more specific than "Phosphofructokinase-1, Muscle Type".
This graph shows the total number of publications written about "Phosphofructokinase-1, Muscle Type" by people in Harvard Catalyst Profiles by year, and whether "Phosphofructokinase-1, Muscle Type" was a major or minor topic of these publication.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Phosphofructokinase-1, Muscle Type" by people in Profiles.
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Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell. 2021 05 06; 81(9):1905-1919.e12.
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A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69.
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Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity. Diabetes. 2014 Mar; 63(3):1154-65.