Complement C3a

"Complement C3a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The smaller fragment generated from the cleavage of complement C3 by C3 CONVERTASE. C3a, a 77-amino acid peptide, is a mediator of local inflammatory process. It induces smooth MUSCLE CONTRACTION, and HISTAMINE RELEASE from MAST CELLS and LEUKOCYTES. C3a is considered an anaphylatoxin along with COMPLEMENT C4A; COMPLEMENT C5A; and COMPLEMENT C5A, DES-ARGININE.

Descriptor ID

D015926

MeSH Number(s)

D12.776.124.486.274.024.250

D12.776.124.486.274.250.250

Concept/Terms

Complement C3a

Below are MeSH descriptors whose meaning is more general than "Complement C3a".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Anaphylatoxins [D12.776.124.486.274.024]
Complement C3a [D12.776.124.486.274.024.250]
Complement C3 [D12.776.124.486.274.250]
Complement C3a [D12.776.124.486.274.250.250]

Below are MeSH descriptors whose meaning is related to "Complement C3a".

Below are MeSH descriptors whose meaning is more specific than "Complement C3a".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C3a" by people in Harvard Catalyst Profiles by year, and whether "Complement C3a" was a major or minor topic of these publication.

Bar chart showing 36 publications over 20 distinct years, with a maximum of 4 publications in 1996 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	2	4
1998	1	0	1
2000	0	1	1
2003	2	1	3
2004	1	1	2
2005	3	1	4
2006	0	2	2
2007	0	2	2
2008	0	1	1
2009	0	1	1
2010	0	3	3
2011	1	1	2
2012	0	1	1
2013	0	1	1
2014	0	2	2
2015	1	0	1
2016	1	0	1
2018	1	1	2
2019	1	0	1
2021	1	0	1

Below are the most recent publications written about "Complement C3a" by people in Profiles.

Dynamic regulation of B cell complement signaling is integral to germinal center responses. Nat Immunol. 2021 06; 22(6):757-768.

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Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019 11; 25(11):1739-1747.

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C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway. Sci Rep. 2018 06 26; 8(1):9679.

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Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. Biochem Pharmacol. 2018 05; 151:245-251.

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Complement Activation in Trauma Patients Alters Platelet Function. Shock. 2016 09; 46(3 Suppl 1):83-8.

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A local complement response by RPE causes early-stage macular degeneration. Hum Mol Genet. 2015 Oct 01; 24(19):5555-69.

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Adipsin is an adipokine that improves ß cell function in diabetes. Cell. 2014 Jul 03; 158(1):41-53.

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Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia. Hypertension. 2014 Oct; 64(4):833-8.

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Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. PLoS One. 2014; 9(4):e95160.

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Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41.

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