Receptors, Serotonin, 5-HT4
"Receptors, Serotonin, 5-HT4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subtype of G-protein-coupled SEROTONIN receptors that preferentially couple to GS STIMULATORY G-PROTEINS resulting in increased intracellular CYCLIC AMP. Several isoforms of the receptor exist due to ALTERNATIVE SPLICING of its mRNA.
MeSH Number(s)
D12.776.543.750.070.800.400
D12.776.543.750.100.800.400
D12.776.543.750.720.300.800.400
Concept/Terms
Receptors, Serotonin, 5-HT4- Receptors, Serotonin, 5-HT4
- Serotonin 4 Receptors
- Receptors, Serotonin 4
- Receptor, Serotonin 4
- Serotonin 4 Receptor
- 5-HT4 Receptor
- 5 HT4 Receptor
- Receptor, 5-HT4
- 5-Hydroxytryptamine-4 Receptor
- 5 Hydroxytryptamine 4 Receptor
- Receptor, 5-Hydroxytryptamine-4
Below are MeSH descriptors whose meaning is more general than "Receptors, Serotonin, 5-HT4".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Biogenic Amine [D12.776.543.750.070]
- Receptors, Serotonin [D12.776.543.750.070.800]
- Receptors, Serotonin, 5-HT4 [D12.776.543.750.070.800.400]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Serotonin [D12.776.543.750.100.800]
- Receptors, Serotonin, 5-HT4 [D12.776.543.750.100.800.400]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Biogenic Amine [D12.776.543.750.720.300]
- Receptors, Serotonin [D12.776.543.750.720.300.800]
- Receptors, Serotonin, 5-HT4 [D12.776.543.750.720.300.800.400]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Serotonin, 5-HT4".
This graph shows the total number of publications written about "Receptors, Serotonin, 5-HT4" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Serotonin, 5-HT4" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2005 | 1 | 0 | 1 |
2006 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2010 | 0 | 1 | 1 |
2011 | 0 | 1 | 1 |
2012 | 1 | 0 | 1 |
2013 | 1 | 0 | 1 |
2015 | 1 | 0 | 1 |
2016 | 0 | 1 | 1 |
2018 | 2 | 0 | 2 |
2020 | 2 | 0 | 2 |
Below are the most recent publications written about "Receptors, Serotonin, 5-HT4" by people in Profiles.
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False positive rates in positron emission tomography (PET) voxelwise analyses. J Cereb Blood Flow Metab. 2021 07; 41(7):1647-1657.
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Therapeutic potential of serotonin 4 receptor for chronic depression and its associated comorbidity in the gut. Neuropharmacology. 2020 04; 166:107969.
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Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding. Cephalalgia. 2019 04; 39(4):526-532.
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High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study. Neuroimage Clin. 2018; 18:97-102.
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Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 01; 312(4):L520-L530.
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Combination of exogenous cell transplantation and 5-HT4 receptor agonism induce endogenous enteric neural crest-derived cells in a rat hypoganglionosis model. Exp Cell Res. 2017 02 01; 351(1):36-42.
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The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus. Hippocampus. 2016 07; 26(7):875-91.
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Luminal 5-HT stimulates colonic bicarbonate secretion in rats. Br J Pharmacol. 2015 Oct; 172(19):4655-70.
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Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. FASEB J. 2015 Jan; 29(1):323-35.
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Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data. Neuroimage. 2014 May 15; 92:225-36.