Retinoblastoma-Like Protein p130

"Retinoblastoma-Like Protein p130" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.

Descriptor ID

D050717

MeSH Number(s)

D12.776.624.776.735

D12.776.660.794

D12.776.744.755

Concept/Terms

Retinoblastoma-Like Protein p130

Below are MeSH descriptors whose meaning is more general than "Retinoblastoma-Like Protein p130".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Retinoblastoma-Like Protein p130 [D12.776.624.776.735]
Nuclear Proteins [D12.776.660]
Retinoblastoma-Like Protein p130 [D12.776.660.794]
Phosphoproteins [D12.776.744]
Retinoblastoma-Like Protein p130 [D12.776.744.755]

Below are MeSH descriptors whose meaning is related to "Retinoblastoma-Like Protein p130".

Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma-Like Protein p130".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinoblastoma-Like Protein p130" by people in Harvard Catalyst Profiles by year, and whether "Retinoblastoma-Like Protein p130" was a major or minor topic of these publication.

Bar chart showing 53 publications over 22 distinct years, with a maximum of 7 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	3	3
1997	0	7	7
1998	0	6	6
1999	0	1	1
2000	0	6	6
2001	0	3	3
2002	0	4	4
2003	0	3	3
2004	0	3	3
2005	1	2	3
2007	1	1	2
2011	0	1	1
2012	0	1	1
2013	0	1	1
2014	0	1	1
2015	0	1	1
2018	0	1	1
2019	1	1	2
2021	1	0	1
2022	0	1	1
2024	0	1	1

Below are the most recent publications written about "Retinoblastoma-Like Protein p130" by people in Profiles.

RBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis. Cell Death Dis. 2024 01 22; 15(1):81.

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Loss of Rbl2 (Retinoblastoma-Like 2) Exacerbates Myocardial Ischemia/Reperfusion Injury. J Am Heart Assoc. 2022 10 04; 11(19):e024764.

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Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. Elife. 2021 12 01; 10.

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CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):513-521.

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RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activation. Nucleic Acids Res. 2019 12 02; 47(21):11197-11208.

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A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family. PLoS One. 2018; 13(12):e0208110.

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Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis. Int J Oncol. 2015 May; 46(5):2039-46.

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The DREAM complex in antitumor activity of imatinib mesylate in gastrointestinal stromal tumors. Curr Opin Oncol. 2014 Jul; 26(4):415-21.

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Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR. Nat Genet. 2014 Jan; 46(1):39-44.

View in: PubMed
Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis. J Clin Endocrinol Metab. 2012 Sep; 97(9):3224-30.

View in: PubMed

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