Argininosuccinate Synthase

"Argininosuccinate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.

Descriptor ID

D001124

MeSH Number(s)

D08.811.464.259.300

Concept/Terms

Argininosuccinate Synthase

Below are MeSH descriptors whose meaning is more general than "Argininosuccinate Synthase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Carbon-Nitrogen Ligases [D08.811.464.259]
Argininosuccinate Synthase [D08.811.464.259.300]

Below are MeSH descriptors whose meaning is related to "Argininosuccinate Synthase".

Below are MeSH descriptors whose meaning is more specific than "Argininosuccinate Synthase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Argininosuccinate Synthase" by people in Harvard Catalyst Profiles by year, and whether "Argininosuccinate Synthase" was a major or minor topic of these publication.

Bar chart showing 5 publications over 4 distinct years, with a maximum of 2 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
2016	2	0	2
2017	0	1	1
2018	0	1	1

Below are the most recent publications written about "Argininosuccinate Synthase" by people in Profiles.

Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans. Nat Commun. 2023 03 03; 14(1):1215.

View in: PubMed
Does Argininosuccinate Synthase 1 (ASS1) Immunohistochemistry Predict an Increased Risk of Hemorrhage for Hepatocellular Adenomas? Appl Immunohistochem Mol Morphol. 2020 07; 28(6):464-470.

View in: PubMed
The utility of EEG monitoring in neonates with hyperammonemia due to inborn errors of metabolism. Mol Genet Metab. 2018 11; 125(3):235-240.

View in: PubMed
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Cell Metab. 2018 Jun 05; 27(6):1263-1280.e6.

View in: PubMed
Targeting Metabolism for Cancer Therapy. Cell Chem Biol. 2017 Sep 21; 24(9):1161-1180.

View in: PubMed
The ADAM Trial: Visiting the Road Less Traveled. JAMA Oncol. 2017 01 01; 3(1):66-67.

View in: PubMed
Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance. Oncotarget. 2016 Oct 25; 7(43):70832-70844.

View in: PubMed
Arginine dependence of tumor cells: targeting a chink in cancer's armor. Oncogene. 2016 09 22; 35(38):4957-72.

View in: PubMed
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. PLoS One. 2016; 11(3):e0150044.

View in: PubMed
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.

View in: PubMed

Related Networks

People

Explore

Similar Concepts

Top Journals

Somat Cell Mol Genet
Mol Cell Biol
Metabolism
JAMA Oncol
J Inherit Metab Dis
Clin Chim Acta
Cancer
Biochim Biophys Acta
Appl Immunohistochem Mol Morphol
Am J Hum Genet