Receptors, Proteinase-Activated
"Receptors, Proteinase-Activated" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites.
Concept/Terms
Receptors, Proteinase-Activated- Receptors, Proteinase-Activated
- Receptors, Proteinase Activated
- Protease-Activated Receptors
- Protease Activated Receptors
- Receptors, Protease-Activated
- Proteinase-Activated Receptors
- Proteinase Activated Receptors
- Endopeptidase-Activated Receptors
- Endopeptidase Activated Receptors
- Receptors, Endopeptidase-Activated
Below are MeSH descriptors whose meaning is more general than "Receptors, Proteinase-Activated".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Proteinase-Activated".
This graph shows the total number of publications written about "Receptors, Proteinase-Activated" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Proteinase-Activated" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 1 | 3 |
| 2010 | 2 | 0 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptors, Proteinase-Activated" by people in Profiles.
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Microscopic in-situ analysis of the mucosal healing around implants treated by protease activated receptor 4-agonist peptide or perpendicularly protruded type I collagen in rats. J Biomed Mater Res B Appl Biomater. 2024 01; 112(1):e35330.
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Cell type-specific roles of PAR1 in Coxsackievirus B3 infection. Sci Rep. 2021 07 12; 11(1):14264.
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TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice. Arterioscler Thromb Vasc Biol. 2018 02; 38(2):344-352.
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Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets. PLoS One. 2016; 11(10):e0165565.
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A combined deficiency of tissue factor and PAR-4 is associated with fatal pulmonary hemorrhage in mice. Thromb Res. 2016 Oct; 146:46-50.
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Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Commun. 2015 Jul 28; 6:7864.
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Protease-activated receptors and itch. Handb Exp Pharmacol. 2015; 226:219-35.
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Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option? Biol Res. 2014 Nov 18; 47:58.
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Differential signaling by protease-activated receptors: implications for therapeutic targeting. Int J Mol Sci. 2014 Apr 11; 15(4):6169-83.
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Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. Br J Pharmacol. 2014 Mar; 171(5):1180-94.