Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
"Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
Concept/Terms
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase- Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
- 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine
- 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate
- Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase
- Protocollagen Lysyl Hydroxylase
- Hydroxylase, Protocollagen Lysyl
- Lysine Hydroxylase
- Hydroxylase, Lysine
- Lysyl Hydroxylase
- Hydroxylase, Lysyl
- Collagen Lysyl Hydroxylase
- Hydroxylase, Collagen Lysyl
- Lysine 2-Oxoglutarate Dioxygenase
- 2-Oxoglutarate Dioxygenase, Lysine
- Dioxygenase, Lysine 2-Oxoglutarate
- Lysine 2 Oxoglutarate Dioxygenase
Below are MeSH descriptors whose meaning is more general than "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase".
This graph shows the total number of publications written about "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" by people in Harvard Catalyst Profiles by year, and whether "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase" by people in Profiles.
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Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas. Neoplasia. 2021 06; 23(6):594-606.
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PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer. Int J Cancer. 2018 09 01; 143(5):1202-1211.
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Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2. J Bone Miner Res. 2018 04; 33(4):753-760.
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Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS One. 2017; 12(8):e0184028.
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Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis. Cancer Discov. 2013 Oct; 3(10):1190-205.
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Global secretome analysis identifies novel mediators of bone metastasis. Cell Res. 2012 Sep; 22(9):1339-55.
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Low oxygen concentrations impair tissue development in tissue-engineered cardiovascular constructs. Tissue Eng Part A. 2012 Feb; 18(3-4):221-31.
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Phenotypic variability of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA): clinical, molecular and biochemical delineation. Orphanet J Rare Dis. 2011 Jun 23; 6:46.
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Expression profiling of genes involved in collagen turnover in tendons from cerebral palsy patients. Connect Tissue Res. 2009; 50(3):203-8.
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Altered expression of connective tissue genes in postnatal chondroinduced human dermal fibroblasts. Connect Tissue Res. 2003; 44(3-4):121-7.