Smad3 Protein

"Smad3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

Descriptor ID

D051900

MeSH Number(s)

D12.644.360.024.334.500.300

D12.776.157.057.170.500.300

D12.776.260.713.500.300

D12.776.476.024.417.500.300

D12.776.744.741.875

D12.776.930.806.500.300

Concept/Terms

Smad3 Protein

Below are MeSH descriptors whose meaning is more general than "Smad3 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Smad Proteins [D12.644.360.024.334]
Smad Proteins, Receptor-Regulated [D12.644.360.024.334.500]
Smad3 Protein [D12.644.360.024.334.500.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Smad Proteins [D12.776.157.057.170]
Smad Proteins, Receptor-Regulated [D12.776.157.057.170.500]
Smad3 Protein [D12.776.157.057.170.500.300]
DNA-Binding Proteins [D12.776.260]
Smad Proteins [D12.776.260.713]
Smad Proteins, Receptor-Regulated [D12.776.260.713.500]
Smad3 Protein [D12.776.260.713.500.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Smad Proteins [D12.776.476.024.417]
Smad Proteins, Receptor-Regulated [D12.776.476.024.417.500]
Smad3 Protein [D12.776.476.024.417.500.300]
Phosphoproteins [D12.776.744]
Smad Proteins, Receptor-Regulated [D12.776.744.741]
Smad3 Protein [D12.776.744.741.875]
Transcription Factors [D12.776.930]
Smad Proteins [D12.776.930.806]
Smad Proteins, Receptor-Regulated [D12.776.930.806.500]
Smad3 Protein [D12.776.930.806.500.300]

Below are MeSH descriptors whose meaning is related to "Smad3 Protein".

Below are MeSH descriptors whose meaning is more specific than "Smad3 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Smad3 Protein" by people in Harvard Catalyst Profiles by year, and whether "Smad3 Protein" was a major or minor topic of these publication.

Bar chart showing 123 publications over 26 distinct years, with a maximum of 11 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1998	0	2	2
1999	0	4	4
2000	0	6	6
2001	0	2	2
2002	0	2	2
2003	0	4	4
2004	0	3	3
2005	0	6	6
2006	2	5	7
2007	2	1	3
2008	4	0	4
2009	2	4	6
2010	1	6	7
2011	0	3	3
2012	2	6	8
2013	2	4	6
2014	5	5	10
2015	0	4	4
2016	3	3	6
2017	4	2	6
2018	3	3	6
2019	2	9	11
2020	1	0	1
2021	0	4	4
2023	0	1	1

Below are the most recent publications written about "Smad3 Protein" by people in Profiles.

POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis. Cancer Lett. 2024 02 01; 582:216526.

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SMAD2/3 mediate oncogenic effects of TGF-ß in the absence of SMAD4. Commun Biol. 2022 10 07; 5(1):1068.

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Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease. Int J Mol Sci. 2021 Nov 30; 22(23).

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PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-ß1-receptor signaling. FASEB J. 2021 07; 35(7):e21725.

View in: PubMed
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis. Nat Commun. 2021 05 19; 12(1):2923.

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ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-ß1. Proc Natl Acad Sci U S A. 2021 05 04; 118(18).

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Full-length IL-33 regulates Smad3 phosphorylation and gene transcription in a distinctive AP2-dependent manner. Cell Immunol. 2020 11; 357:104203.

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Genotypic Categorization of Loeys-Dietz Syndrome Based on 24 Novel Families and Literature Data. Genes (Basel). 2019 09 28; 10(10).

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H3K18ac Primes Mesendodermal Differentiation upon Nodal Signaling. Stem Cell Reports. 2019 10 08; 13(4):642-656.

View in: PubMed
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes. Mol Cell. 2019 12 05; 76(5):753-766.e6.

View in: PubMed

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