D012436Chemicals & DrugsD02.886.030.676.180D03.438.759.590.138.264D12.125.166.676.180D13.570.583.138.264D13.570.800.096.2641062120.866029S-Adenosylmethioninecatalyst:eCommonsLogineCommons LoginFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson5.290430.0020494106research area of0.9873660.00661532198subject area forMedicinePsychiatryCardiologyBrigham and Women's HospitalMassachusetts General HospitalMcLean HospitalMMG5MichaelGivertzMichael M. Givertz, M.D.42.33510370000000-71.1061649000000078310Givertz, MichaelProfessor of MedicineDM2DavidMischoulonDavid Mischoulon, M.D., Ph.D.42.36233300000000-71.0640340000000031166Mischoulon, DavidJoyce R. Tedlow Professor of PsychiatryMF13MaurizioFavaMaurizio Fava, M.D.42.36241700000000-71.0689370000000059339Fava, MaurizioSlater Family Professor of PsychiatryBMC1BruceCohenBruce Michael Cohen, M.D.,Ph.D.42.39465440000000-71.1956711000000025041Cohen, BruceRobertson-Steele Professor of PsychiatryGP4GeorgePapakostasGeorge I Papakostas, M.D.42.36233300000000-71.064034000000006414Papakostas, GeorgeProfessor of Psychiatrytrue1Robertson-Steele Professor of PsychiatryRobertson-Steele Professor of Psychiatrytrue1Professor of MedicineProfessor of Medicinetrue1Joyce R. Tedlow Professor of PsychiatryJoyce R. Tedlow Professor of Psychiatry33595776Joseph J, Giczewska A, Alhanti B, Cheema AK, Handy DE, Mann DL, Loscalzo J, Givertz MMJournal of physiology and biochemistryAssociations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure. J Physiol Biochem. 2021 May; 77(2):295-304.J Physiol Biochem2021-02-17T00:00:002021Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure.33756106Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra IMolecular cellmTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. Mol Cell. 2021 05 20; 81(10):2076-2093.e9.Mol Cell2021-03-22T00:00:002021mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.true1Professor of PsychiatryProfessor of Psychiatry36678154Lerin C, Collado MC, Isganaitis E, Arning E, Wasek B, Demerath EW, Fields DA, Bottiglieri TNutrientsRevisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine. Nutrients. 2023 Jan 05; 15(2).Nutrients2023-01-05T00:00:002023Revisiting One-Carbon Metabolites in Human Breast Milk: Focus on S-Adenosylmethionine.true1Slater Family Professor of PsychiatrySlater Family Professor of Psychiatry38243132Kang J, Benjamin DI, Kim S, Salvi JS, Dhaliwal G, Lam R, Goshayeshi A, Brett JO, Liu L, Rando TANature metabolismDepletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing. Nat Metab. 2024 Jan; 6(1):153-168.Nat Metab2024-01-19T00:00:002024Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing.34449924Ramani K, Robinson AE, Berlind J, Fan W, Abeynayake A, Binek A, Barbier-Torres L, Noureddin M, Nissen NN, Yildirim Z, Erbay E, Mato JM, Van Eyk JE, Lu SCHepatology (Baltimore, Md.)S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells. Hepatology. 2022 02; 75(2):280-296.Hepatology2021-12-18T00:00:002021S-adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells.0Full Professor