Hepatocyte Nuclear Factor 1

"Hepatocyte Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcription factor that regulates the expression of a large set of hepatic proteins including SERUM ALBUMIN; beta-fibrinogen; and ALPHA 1-ANTITRYPSIN. It is composed of hetero- or homo-dimers of HEPATOCYTE NUCLEAR FACTOR 1-ALPHA and HEPATOCYTE NUCLEAR FACTOR 1-BETA.

Descriptor ID

D051537

MeSH Number(s)

D12.776.260.262.500

D12.776.660.352.500

D12.776.930.323.500

Concept/Terms

Hepatocyte Nuclear Factor 1

Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 1".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Hepatocyte Nuclear Factors [D12.776.260.262]
Hepatocyte Nuclear Factor 1 [D12.776.260.262.500]
Nuclear Proteins [D12.776.660]
Hepatocyte Nuclear Factors [D12.776.660.352]
Hepatocyte Nuclear Factor 1 [D12.776.660.352.500]
Transcription Factors [D12.776.930]
Hepatocyte Nuclear Factors [D12.776.930.323]
Hepatocyte Nuclear Factor 1 [D12.776.930.323.500]

Below are MeSH descriptors whose meaning is related to "Hepatocyte Nuclear Factor 1".

Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 1" by people in Harvard Catalyst Profiles by year, and whether "Hepatocyte Nuclear Factor 1" was a major or minor topic of these publication.

Bar chart showing 20 publications over 9 distinct years, with a maximum of 3 publications in 2000 and 2002 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1998	0	2	2
1999	0	2	2
2000	0	3	3
2002	0	3	3
2003	0	2	2
2004	0	3	3
2005	1	1	2
2009	0	2	2

Below are the most recent publications written about "Hepatocyte Nuclear Factor 1" by people in Profiles.

Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19934-9.

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A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. J Cell Mol Med. 2009 Apr; 13(4):680-92.

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Pancreatic exocrine insufficiency is not common in HNF-1alpha MODY. Diabet Med. 2008 May; 25(5):627-30.

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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005 Dec; 2(6):373-84.

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Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol. 2006 May; 290(5):G1016-24.

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Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes. Diabetes. 2005 Aug; 54(8):2336-42.

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Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 2004 Dec 03; 578(1-2):63-8.

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Two distinct teleost hepatocyte nuclear factor 1 genes, hnf1alpha/tcf1 and hnf1beta/tcf2, abundantly expressed in liver, pancreas, gut and kidney of zebrafish. Gene. 2004 Aug 18; 338(1):35-46.

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Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004 Nov; 287(5):G943-53.

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Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G899-909.

View in: PubMed

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