"Apoprotein(a)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large and highly glycosylated protein constituent of LIPOPROTEIN (A). It has very little affinity for lipids but forms disulfide-linkage to APOLIPOPROTEIN B-100. Apoprotein(a) has SERINE PROTEINASE activity and can be of varying sizes from 400- to 800-kDa. It is homologous to PLASMINOGEN and is known to modulate THROMBOSIS and FIBRINOLYSIS.
MeSH Number(s)
D10.532.350.500
D12.776.521.400.500
Concept/Terms
Apoprotein(a)- Apoprotein(a)
- Apo Lp(a)
- Apolipoprotein (a)
- Apoprotein (a)
- Apolipoprotein Lp(a+)
- Apolipoprotein(a)
- Antiangiogenic AK38 Protein
- Protein, Antiangiogenic AK38
- Apolipoprotein Lp(a)
Below are MeSH descriptors whose meaning is more general than "Apoprotein(a)".
Below are MeSH descriptors whose meaning is more specific than "Apoprotein(a)".
This graph shows the total number of publications written about "Apoprotein(a)" by people in Harvard Catalyst Profiles by year, and whether "Apoprotein(a)" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2004 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2015 | 1 | 0 | 1 |
2018 | 1 | 0 | 1 |
2019 | 2 | 0 | 2 |
2020 | 0 | 1 | 1 |
2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Apoprotein(a)" by people in Profiles.
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Lipoprotein(a), Oxidized Phospholipids, and Coronary Artery Disease Severity and Outcomes. J Am Coll Cardiol. 2023 05 09; 81(18):1780-1792.
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PCSK9 Inhibition with alirocumab increases the catabolism of lipoprotein(a) particles in statin-treated patients with elevated lipoprotein(a). Metabolism. 2020 06; 107:154221.
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Apolipoprotein(a) Kinetics in Statin-Treated Patients With Elevated Plasma Lipoprotein(a) Concentration. J Clin Endocrinol Metab. 2019 12 01; 104(12):6247-6255.
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Lipoprotein(a) Particle Production as a Determinant of Plasma Lipoprotein(a) Concentration Across Varying Apolipoprotein(a) Isoform Sizes and Background Cholesterol-Lowering Therapy. J Am Heart Assoc. 2019 04 02; 8(7):e011781.
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Lipoprotein(a) and apolipoprotein(a) isoform size: Associations with angiographic extent and severity of coronary artery disease, and carotid artery plaque. Atherosclerosis. 2018 08; 275:232-238.
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Production of human apolipoprotein(a) transgenic NIBS miniature pigs by somatic cell nuclear transfer. Exp Anim. 2016; 65(1):37-43.
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Trial Watch: Antisenses working overtime in lipids. Nat Rev Endocrinol. 2015 Oct; 11(10):574-6.
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Lipoprotein(a), measured with an assay independent of apolipoprotein(a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA. 2006 Sep 20; 296(11):1363-70.
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Apolipoprotein(a) size and lipoprotein(a) concentration and future risk of angina pectoris with evidence of severe coronary atherosclerosis in men: The Physicians' Health Study. Clin Chem. 2004 Aug; 50(8):1364-71.
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Prominence of apolipoproteins B, (a), and E in the intimae of coronary arteries in transplanted human hearts: geographic relationship to vessel wall proteoglycans. J Heart Lung Transplant. 1996 Dec; 15(12):1223-32.