Alu Elements

"Alu Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.

Descriptor ID

D020087

MeSH Number(s)

G02.111.570.080.708.330.800.800.050

G05.360.080.708.330.800.800.050

G05.360.340.024.425.800.800.050

Concept/Terms

Alu Elements

Alu-Like Repetitive Sequence

Below are MeSH descriptors whose meaning is more general than "Alu Elements".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
Repetitive Sequences, Nucleic Acid [G02.111.570.080.708]
Interspersed Repetitive Sequences [G02.111.570.080.708.330]
Retroelements [G02.111.570.080.708.330.800]
Short Interspersed Nucleotide Elements [G02.111.570.080.708.330.800.800]
Alu Elements [G02.111.570.080.708.330.800.800.050]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Repetitive Sequences, Nucleic Acid [G05.360.080.708]
Interspersed Repetitive Sequences [G05.360.080.708.330]
Retroelements [G05.360.080.708.330.800]
Short Interspersed Nucleotide Elements [G05.360.080.708.330.800.800]
Alu Elements [G05.360.080.708.330.800.800.050]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Interspersed Repetitive Sequences [G05.360.340.024.425]
Retroelements [G05.360.340.024.425.800]
Short Interspersed Nucleotide Elements [G05.360.340.024.425.800.800]
Alu Elements [G05.360.340.024.425.800.800.050]

Below are MeSH descriptors whose meaning is related to "Alu Elements".

Below are MeSH descriptors whose meaning is more specific than "Alu Elements".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alu Elements" by people in Harvard Catalyst Profiles by year, and whether "Alu Elements" was a major or minor topic of these publication.

Bar chart showing 52 publications over 19 distinct years, with a maximum of 9 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	2	0	2
2001	0	1	1
2002	1	0	1
2004	2	0	2
2007	2	0	2
2009	2	3	5
2010	1	1	2
2011	5	4	9
2012	3	3	6
2013	2	0	2
2014	1	2	3
2015	1	3	4
2016	0	2	2
2017	1	0	1
2018	2	2	4
2019	3	0	3
2021	0	1	1
2023	0	1	1

Below are the most recent publications written about "Alu Elements" by people in Profiles.

The landscape of human SVA retrotransposons. Nucleic Acids Res. 2023 Nov 27; 51(21):11453-11465.

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NGS-based identification and tracing of microsatellite instability from minute amounts DNA using inter-Alu-PCR. Nucleic Acids Res. 2021 02 26; 49(4):e24.

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B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):415-425.

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TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation. Mol Cell. 2020 02 06; 77(3):475-487.e11.

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Alu insertion variants alter mRNA splicing. Nucleic Acids Res. 2019 01 10; 47(1):421-431.

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Prenatal phthalate exposure, birth outcomes and DNA methylation of Alu and LINE-1 repetitive elements: A pilot study in China. Chemosphere. 2018 Sep; 206:759-765.

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Dissecting the Causal Mechanism of X-Linked Dystonia-Parkinsonism by Integrating Genome and Transcriptome Assembly. Cell. 2018 02 22; 172(5):897-909.e21.

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Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell. 2018 02 08; 172(4):797-810.e13.

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Alu element insertion in PKLR gene as a novel cause of pyruvate kinase deficiency in Middle Eastern patients. Hum Mutat. 2018 03; 39(3):389-393.

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Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018 01 11; 8(1):461.

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