"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
Concept/Terms
Giant Cells- Giant Cells
- Cell, Giant
- Cells, Giant
- Giant Cell
- Syncytium
- Polykaryocytes
- Polykaryocyte
- Syncytia
- Giant Cells, Multinucleated
- Cell, Multinucleated Giant
- Cells, Multinucleated Giant
- Giant Cell, Multinucleated
- Multinucleated Giant Cell
- Multinucleated Giant Cells
Below are MeSH descriptors whose meaning is more general than "Giant Cells".
Below are MeSH descriptors whose meaning is more specific than "Giant Cells".
This graph shows the total number of publications written about "Giant Cells" by people in Harvard Catalyst Profiles by year, and whether "Giant Cells" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 2 | 5 |
| 1995 | 2 | 4 | 6 |
| 1996 | 3 | 7 | 10 |
| 1997 | 1 | 5 | 6 |
| 1998 | 1 | 6 | 7 |
| 1999 | 2 | 6 | 8 |
| 2000 | 3 | 3 | 6 |
| 2001 | 4 | 6 | 10 |
| 2002 | 0 | 6 | 6 |
| 2003 | 1 | 3 | 4 |
| 2004 | 2 | 3 | 5 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 2 | 3 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 2 | 3 |
| 2013 | 2 | 2 | 4 |
| 2014 | 1 | 1 | 2 |
| 2015 | 4 | 0 | 4 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 4 | 5 |
| 2018 | 0 | 2 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 3 | 4 | 7 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 2 | 2 |
Below are the most recent publications written about "Giant Cells" by people in Profiles.
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Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53. Cell Rep. 2023 12 26; 42(12):113478.
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Giant cell-rich osteosarcoma: A match pair analysis of 11 new cases and literature review of 56 patients. J Surg Oncol. 2023 Oct; 128(5):877-890.
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Update of pediatric bone tumors: osteogenic tumors and osteoclastic giant cell-rich tumors. Skeletal Radiol. 2023 Apr; 52(4):671-685.
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Giant Cell Myocarditis and Left Ventricular Apical Aneurysm in a Child With Severe Combined Immunodeficiency. Circ Cardiovasc Imaging. 2021 12; 14(12):1157-1158.
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Sclerostin Immunohistochemical Staining in Aggressive Maxillofacial Giant Cell Lesions: Initial Results and Potential Therapeutic Target. J Craniofac Surg. 2022 May 01; 33(3):790-793.
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Mechanosensing by TRPV4 mediates stiffness-induced foreign body response and giant cell formation. Sci Signal. 2021 Nov 02; 14(707):eabd4077.
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Giant Cell Myocarditis in Children: Elusive Giant Cells Might Not Be the Only Clue. Pediatr Dev Pathol. 2022 Mar-Apr; 25(2):197-202.
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SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation. Elife. 2021 04 23; 10.
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Primary differentiated respiratory epithelial cells respond to apical measles virus infection by shedding multinucleated giant cells. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).
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Durable Response to PD-1 Blockade in a Patient With Metastatic Pancreatic Undifferentiated Carcinoma With Osteoclast-Like Giant Cells. J Natl Compr Canc Netw. 2021 03; 19(3):247-252.