Fanconi Anemia Complementation Group D2 Protein
"Fanconi Anemia Complementation Group D2 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Fanconi anemia complementation group protein that undergoes mono-ubiquitination by FANCL PROTEIN in response to DNA DAMAGE. Also, in response to IONIZING RADIATION it can undergo PHOSPHORYLATION by ataxia telangiectasia mutated protein. Modified FANCD2 interacts with BRCA2 PROTEIN in a stable complex with CHROMATIN, and it is involved in DNA REPAIR by homologous RECOMBINATION.
MeSH Number(s)
D12.776.313.812
D12.776.660.285
D12.776.744.484
Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia Complementation Group D2 Protein".
Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia Complementation Group D2 Protein".
This graph shows the total number of publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in Harvard Catalyst Profiles by year, and whether "Fanconi Anemia Complementation Group D2 Protein" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2001 | 0 | 3 | 3 |
2002 | 0 | 8 | 8 |
2003 | 0 | 5 | 5 |
2004 | 0 | 5 | 5 |
2005 | 0 | 4 | 4 |
2006 | 1 | 1 | 2 |
2007 | 2 | 2 | 4 |
2008 | 1 | 2 | 3 |
2009 | 5 | 3 | 8 |
2010 | 2 | 4 | 6 |
2011 | 3 | 4 | 7 |
2012 | 1 | 4 | 5 |
2013 | 1 | 6 | 7 |
2014 | 1 | 2 | 3 |
2015 | 2 | 2 | 4 |
2016 | 3 | 2 | 5 |
2017 | 1 | 0 | 1 |
2018 | 7 | 2 | 9 |
2019 | 3 | 0 | 3 |
2020 | 1 | 1 | 2 |
2021 | 0 | 2 | 2 |
Below are the most recent publications written about "Fanconi Anemia Complementation Group D2 Protein" by people in Profiles.
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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks. Dev Cell. 2021 08 09; 56(15):2207-2222.e7.
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FANCM regulates repair pathway choice at stalled replication forks. Mol Cell. 2021 06 03; 81(11):2428-2444.e6.
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WRNIP1 Is Recruited to DNA Interstrand Crosslinks and Promotes Repair. Cell Rep. 2020 07 07; 32(1):107850.
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Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair. Nucleic Acids Res. 2020 04 06; 48(6):3014-3028.
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Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS One. 2019; 14(11):e0221288.
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Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep. 2019 06 04; 27(10):2990-3005.e5.
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Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Rep. 2019 01 15; 26(3):564-572.e5.
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Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein. PLoS Genet. 2018 10; 14(10):e1007643.
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Combination therapy with atorvastatin and celecoxib delays tumor formation in a Fanconi anemia mouse model. Pediatr Blood Cancer. 2019 01; 66(1):e27460.
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Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia. Nat Commun. 2018 09 25; 9(1):3915.