Nuclear Localization Signals

"Nuclear Localization Signals" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.

Descriptor ID

D019913

MeSH Number(s)

D12.644.770.610

G02.111.570.060.670.610

Concept/Terms

Nuclear Localization Signals

Below are MeSH descriptors whose meaning is more general than "Nuclear Localization Signals".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Protein Sorting Signals [D12.644.770]
Nuclear Localization Signals [D12.644.770.610]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Amino Acid Sequence [G02.111.570.060]
Protein Sorting Signals [G02.111.570.060.670]
Nuclear Localization Signals [G02.111.570.060.670.610]

Below are MeSH descriptors whose meaning is related to "Nuclear Localization Signals".

Below are MeSH descriptors whose meaning is more specific than "Nuclear Localization Signals".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nuclear Localization Signals" by people in Harvard Catalyst Profiles by year, and whether "Nuclear Localization Signals" was a major or minor topic of these publication.

Bar chart showing 66 publications over 23 distinct years, with a maximum of 5 publications in 2001 and 2004 and 2006 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	2	0	2
1999	0	3	3
2000	0	2	2
2001	1	4	5
2002	0	2	2
2003	1	1	2
2004	2	3	5
2005	1	1	2
2006	1	4	5
2007	1	2	3
2008	0	1	1
2009	0	4	4
2010	0	3	3
2011	0	3	3
2012	1	1	2
2013	1	3	4
2014	1	1	2
2015	1	3	4
2016	3	0	3
2017	2	3	5
2018	1	1	2
2019	1	0	1
2022	0	1	1

Below are the most recent publications written about "Nuclear Localization Signals" by people in Profiles.

LMNA Variants and Risk of Adult-Onset Cardiac Disease. J Am Coll Cardiol. 2022 07 05; 80(1):50-59.

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A potent nuclear export mechanism imposes USP16 cytoplasmic localization during interphase. J Cell Sci. 2020 02 24; 133(4).

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Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress. J Cell Biochem. 2019 09; 120(9):16088-16107.

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Enhanced Cas12a editing in mammalian cells and zebrafish. Nucleic Acids Res. 2019 May 07; 47(8):4169-4180.

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Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein. Hum Mol Genet. 2019 01 01; 28(1):31-50.

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14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J. 2018 11; 285(22):4196-4213.

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Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation. Nat Commun. 2018 09 06; 9(1):3613.

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The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife. 2018 05 30; 7.

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Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells. Sci Rep. 2017 11 27; 7(1):16345.

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Active Ran regulates anillin function during cytokinesis. Mol Biol Cell. 2017 Nov 15; 28(24):3517-3531.

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