Orotidine-5'-Phosphate Decarboxylase

"Orotidine-5'-Phosphate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.

Descriptor ID

D009964

MeSH Number(s)

D08.811.520.224.125.450

Concept/Terms

Orotidine-5'-Phosphate Decarboxylase

Below are MeSH descriptors whose meaning is more general than "Orotidine-5'-Phosphate Decarboxylase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Carbon Lyases [D08.811.520.224]
Carboxy-Lyases [D08.811.520.224.125]
Orotidine-5'-Phosphate Decarboxylase [D08.811.520.224.125.450]

Below are MeSH descriptors whose meaning is related to "Orotidine-5'-Phosphate Decarboxylase".

Below are MeSH descriptors whose meaning is more specific than "Orotidine-5'-Phosphate Decarboxylase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Orotidine-5'-Phosphate Decarboxylase" by people in Harvard Catalyst Profiles by year, and whether "Orotidine-5'-Phosphate Decarboxylase" was a major or minor topic of these publication.

Below are the most recent publications written about "Orotidine-5'-Phosphate Decarboxylase" by people in Profiles.

Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles. Mol Biol Evol. 2019 09 01; 36(9):1874-1883.

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 2017 Apr 06; 169(2):258-272.e17.

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Protein function annotation with Structurally Aligned Local Sites of Activity (SALSAs). BMC Bioinformatics. 2013; 14 Suppl 3:S13.

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Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. J Am Chem Soc. 2010 May 26; 132(20):7018-24.

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A synthetic circuit for selectively arresting daughter cells to create aging populations. Nucleic Acids Res. 2010 May; 38(8):2727-35.

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Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach. Biochemistry. 2008 Jul 29; 47(30):7785-7.

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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP. J Am Chem Soc. 2008 Feb 06; 130(5):1574-5.

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Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. J Am Chem Soc. 2007 Oct 31; 129(43):12946-7.

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Counter-selectable marker for bacterial-based interaction trap systems. Biotechniques. 2006 Feb; 40(2):179-84.

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Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J Biol Chem. 2005 Jul 08; 280(27):25611-20.

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