Purpura, Thrombotic Thrombocytopenic
"Purpura, Thrombotic Thrombocytopenic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE.
MeSH Number(s)
C15.378.100.802.687.680
C15.378.140.855.925.750.680
C15.378.925.850
C23.550.414.950.687.680
C23.888.885.687.687.680
Concept/Terms
Purpura, Thrombotic Thrombocytopenic- Purpura, Thrombotic Thrombocytopenic
- Purpuras, Thrombotic Thrombocytopenic
- Thrombocytopenic Purpura, Thrombotic
- Thrombocytopenic Purpuras, Thrombotic
- Thrombotic Thrombocytopenic Purpura
- Thrombotic Thrombocytopenic Purpuras
- Microangiopathic Hemolytic Anemia
- Anemia, Microangiopathic Hemolytic
- Anemias, Microangiopathic Hemolytic
- Hemolytic Anemia, Microangiopathic
- Hemolytic Anemias, Microangiopathic
- Microangiopathic Hemolytic Anemias
- Purpura, Thrombotic Thrombopenic
- Purpuras, Thrombotic Thrombopenic
- Thrombopenic Purpura, Thrombotic
- Thrombopenic Purpuras, Thrombotic
- Thrombotic Thrombopenic Purpura
- Thrombotic Thrombopenic Purpuras
- Moschcowitz Disease
- Disease, Moschcowitz
- Moschkowitz Disease
- Disease, Moschkowitz
Congenital Thrombotic Thrombocytopenic Purpura- Congenital Thrombotic Thrombocytopenic Purpura
- Thrombotic Microangiopathy, Familial
- Familial Thrombotic Microangiopathies
- Familial Thrombotic Microangiopathy
- Microangiopathies, Familial Thrombotic
- Microangiopathy, Familial Thrombotic
- Thrombotic Microangiopathies, Familial
- Upshaw-Schulman Syndrome
- Syndrome, Upshaw-Schulman
- Upshaw Schulman Syndrome
- Upshaw Factor, Deficiency of
- Schulman-Upshaw Syndrome
- Schulman Upshaw Syndrome
- Syndrome, Schulman-Upshaw
- Thrombotic Thrombocytopenic Purpura, Congenital
Below are MeSH descriptors whose meaning is more general than "Purpura, Thrombotic Thrombocytopenic".
- Diseases [C]
- Hemic and Lymphatic Diseases [C15]
- Hematologic Diseases [C15.378]
- Blood Coagulation Disorders [C15.378.100]
- Purpura [C15.378.100.802]
- Purpura, Thrombocytopenic [C15.378.100.802.687]
- Purpura, Thrombotic Thrombocytopenic [C15.378.100.802.687.680]
- Blood Platelet Disorders [C15.378.140]
- Thrombocytopenia [C15.378.140.855]
- Thrombotic Microangiopathies [C15.378.140.855.925]
- Purpura, Thrombocytopenic [C15.378.140.855.925.750]
- Purpura, Thrombotic Thrombocytopenic [C15.378.140.855.925.750.680]
- Thrombophilia [C15.378.925]
- Purpura, Thrombotic Thrombocytopenic [C15.378.925.850]
- Pathological Conditions, Signs and Symptoms [C23]
- Pathologic Processes [C23.550]
- Hemorrhage [C23.550.414]
- Purpura [C23.550.414.950]
- Purpura, Thrombocytopenic [C23.550.414.950.687]
- Purpura, Thrombotic Thrombocytopenic [C23.550.414.950.687.680]
- Signs and Symptoms [C23.888]
- Skin Manifestations [C23.888.885]
- Purpura [C23.888.885.687]
- Purpura, Thrombocytopenic [C23.888.885.687.687]
- Purpura, Thrombotic Thrombocytopenic [C23.888.885.687.687.680]
Below are MeSH descriptors whose meaning is more specific than "Purpura, Thrombotic Thrombocytopenic".
This graph shows the total number of publications written about "Purpura, Thrombotic Thrombocytopenic" by people in Harvard Catalyst Profiles by year, and whether "Purpura, Thrombotic Thrombocytopenic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 4 | 0 | 4 |
| 1999 | 2 | 0 | 2 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 1 | 3 |
| 2004 | 4 | 0 | 4 |
| 2005 | 3 | 0 | 3 |
| 2006 | 1 | 0 | 1 |
| 2007 | 4 | 0 | 4 |
| 2008 | 2 | 1 | 3 |
| 2010 | 3 | 0 | 3 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 0 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 1 | 1 | 2 |
| 2015 | 3 | 1 | 4 |
| 2016 | 3 | 0 | 3 |
| 2017 | 6 | 2 | 8 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 6 | 0 | 6 |
| 2021 | 3 | 0 | 3 |
| 2022 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Purpura, Thrombotic Thrombocytopenic" by people in Profiles.
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Psychometric evaluation of a patient-reported outcomes instrument for congenital thrombotic thrombocytopenic purpura. J Patient Rep Outcomes. 2023 Jul 14; 7(1):68.
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Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance. Blood Adv. 2022 09 27; 6(18):5364-5378.
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Case Report: Thrombotic-Thrombocytopenic Purpura Following Ipilimumab and Nivolumab Combination Immunotherapy for Metastatic Melanoma. Front Immunol. 2022; 13:871217.
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Refractory acquired thrombotic thrombocytopenic purpura in a patient with sickle cell trait successfully treated with caplacizumab. Hematology. 2021 Dec; 26(1):590-593.
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Accurate accounting of caplacizumab cost effectiveness. Lancet Haematol. 2021 05; 8(5):e315.
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A case of antisynthetase syndrome with thrombotic thrombocytopenic purpura. Rheumatology (Oxford). 2021 04 06; 60(4):e143-e145.
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Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura. Blood. 2021 02 18; 137(7):969-976.
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Refractory thrombotic thrombocytopenic purpura related to checkpoint inhibitor immunotherapy. Transfusion. 2021 01; 61(1):322-328.
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Cardiovascular Complications and Their Association With Mortality in Patients With Thrombotic Thrombocytopenic Purpura. Am J Med. 2021 02; 134(2):e89-e97.
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Assessing the risk of refractory disease in iTTP. Br J Haematol. 2020 10; 191(2):143-144.