Receptor Tyrosine Kinase-like Orphan Receptors
"Receptor Tyrosine Kinase-like Orphan Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
MeSH Number(s)
D08.811.913.696.620.682.725.400.093
D12.776.543.750.060.233
Concept/Terms
Receptor Tyrosine Kinase-like Orphan Receptors- Receptor Tyrosine Kinase-like Orphan Receptors
- Receptor Tyrosine Kinase like Orphan Receptors
- ROR Tyrosine Kinase Receptors
- Neurotrophic Tyrosine Kinase, Receptor-related Proteins
- Neurotrophic Tyrosine Kinase, Receptor related Proteins
- NTRKR Receptors
Below are MeSH descriptors whose meaning is more general than "Receptor Tyrosine Kinase-like Orphan Receptors".
Below are MeSH descriptors whose meaning is more specific than "Receptor Tyrosine Kinase-like Orphan Receptors".
This graph shows the total number of publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in Harvard Catalyst Profiles by year, and whether "Receptor Tyrosine Kinase-like Orphan Receptors" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 1 | 1 |
2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2009 | 1 | 0 | 1 |
2011 | 1 | 1 | 2 |
2012 | 2 | 0 | 2 |
2013 | 1 | 0 | 1 |
2014 | 1 | 0 | 1 |
2015 | 0 | 1 | 1 |
2016 | 2 | 2 | 4 |
2017 | 3 | 1 | 4 |
2018 | 1 | 0 | 1 |
2019 | 1 | 0 | 1 |
2020 | 1 | 0 | 1 |
2021 | 2 | 2 | 4 |
2022 | 1 | 0 | 1 |
2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Receptor Tyrosine Kinase-like Orphan Receptors" by people in Profiles.
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WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth. Cancer Res. 2023 04 04; 83(7):1016-1030.
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Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer. Cancer Res. 2022 04 15; 82(8):1518-1533.
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A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021 08 05; 184(16):4348-4371.e40.
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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation. J Am Heart Assoc. 2021 07 06; 10(13):e019904.
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Proteomic analysis identifies the E3 ubiquitin ligase Pdzrn3 as a regulatory target of Wnt5a-Ror signaling. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
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MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus. Development. 2021 05 15; 148(10).
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The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons. PLoS Biol. 2020 03; 18(3):e3000657.
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Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):14138-14143.
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Ibrutinib enhances the efficacy of ROR1 bispecific T cell engager mediated cytotoxicity in chronic lymphocytic leukaemia. Br J Haematol. 2019 07; 186(2):380-382.
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Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia. Blood. 2018 07 12; 132(2):170-178.