Isoaspartic Acid

"Isoaspartic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ASPARTIC ACID residue in polypeptide chains that is linked at the beta-carboxyl group instead of at the normal, alpha-carboxyl group, polypeptide linkage. It is a result of the spontaneous decomposition of aspartic acid or ASPARAGINE residues.

Descriptor ID

D026581

MeSH Number(s)

D12.125.067.500.275

D12.125.119.170.275

Concept/Terms

Isoaspartic Acid

Isoaspartate

Below are MeSH descriptors whose meaning is more general than "Isoaspartic Acid".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Amino Acids, Acidic [D12.125.067]
Aspartic Acid [D12.125.067.500]
Isoaspartic Acid [D12.125.067.500.275]
Amino Acids, Dicarboxylic [D12.125.119]
Aspartic Acid [D12.125.119.170]
Isoaspartic Acid [D12.125.119.170.275]

Below are MeSH descriptors whose meaning is related to "Isoaspartic Acid".

Below are MeSH descriptors whose meaning is more specific than "Isoaspartic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Isoaspartic Acid" by people in Harvard Catalyst Profiles by year, and whether "Isoaspartic Acid" was a major or minor topic of these publication.

Bar chart showing 2 publications over 2 distinct years, with a maximum of 1 publications in 2002 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2013	1	0	1

Below are the most recent publications written about "Isoaspartic Acid" by people in Profiles.

Mildly acidic conditions eliminate deamidation artifact during proteolysis: digestion with endoprotease Glu-C at pH 4.5. Amino Acids. 2016 Apr; 48(4):1059-1067.

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Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent. PLoS One. 2013; 8(11):e80758.

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Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice. Anal Chem. 2013 Feb 19; 85(4):2423-30.

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A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues. Amino Acids. 2013 Apr; 44(4):1205-14.

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Protein isoaspartate methyltransferase-mediated 18O-labeling of isoaspartic acid for mass spectrometry analysis. Anal Chem. 2012 Jan 17; 84(2):1056-62.

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Analysis of isoaspartic Acid by selective proteolysis with Asp-N and electron transfer dissociation mass spectrometry. Anal Chem. 2010 Sep 01; 82(17):7485-91.

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Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. Anal Chem. 2008 May 15; 80(10):3882-9.

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Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation. Protein Sci. 2005 Feb; 14(2):452-63.

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Abeta species, including IsoAsp23 Abeta, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathol. 2003 Mar; 105(3):252-8.

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Anal Chem
Amino Acids
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