Aconitate Hydratase

"Aconitate Hydratase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.

Descriptor ID

D000154

MeSH Number(s)

D08.811.520.241.300.050

Concept/Terms

Aconitate Hydratase

Below are MeSH descriptors whose meaning is more general than "Aconitate Hydratase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Oxygen Lyases [D08.811.520.241]
Hydro-Lyases [D08.811.520.241.300]
Aconitate Hydratase [D08.811.520.241.300.050]

Below are MeSH descriptors whose meaning is related to "Aconitate Hydratase".

Below are MeSH descriptors whose meaning is more specific than "Aconitate Hydratase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Aconitate Hydratase" by people in Harvard Catalyst Profiles by year, and whether "Aconitate Hydratase" was a major or minor topic of these publication.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2008 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	1	0	1
2006	0	1	1
2008	0	2	2
2011	1	1	2
2013	0	1	1
2017	1	0	1
2020	1	0	1

Below are the most recent publications written about "Aconitate Hydratase" by people in Profiles.

Expanding the clinical and phenotypic heterogeneity associated with biallelic variants in ACO2. Ann Clin Transl Neurol. 2020 06; 7(6):1013-1028.

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Increased Survival and Partly Preserved Cognition in a Patient With ACO2-Related Disease Secondary to a Novel Variant. J Child Neurol. 2017 08; 32(9):840-845.

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Direct Evidence for Metabolon Formation and Substrate Channeling in Recombinant TCA Cycle Enzymes. ACS Chem Biol. 2016 10 21; 11(10):2847-2853.

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High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J. 2016 Jan; 30(1):417-27.

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Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus. Mol Microbiol. 2015 Feb; 95(3):383-409.

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Mitochondria-targeted antioxidant promotes recovery of skeletal muscle mitochondrial function after burn trauma assessed by in vivo 31P nuclear magnetic resonance and electron paramagnetic resonance spectroscopy. FASEB J. 2013 Jun; 27(6):2521-30.

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Aconitase regulation of erythropoiesis correlates with a novel licensing function in erythropoietin-induced ERK signaling. PLoS One. 2011; 6(8):e23850.

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MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 2011 Jun; 10(3):493-505.

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Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model. Neurobiol Dis. 2011 Jun; 42(3):496-505.

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In vivo evidence for the iron-binding activity of an iron-sulfur cluster assembly protein IscA in Escherichia coli. Biochem J. 2010 Dec 15; 432(3):429-36.

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J Biol Chem
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Ann Clin Transl Neurol
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