Metabolic Detoxication, Phase II
"Metabolic Detoxication, Phase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
MeSH Number(s)
G03.495.244.820.750
G07.690.812.097.600.750
G07.700.680.097.600.750
Concept/Terms
Metabolic Detoxication, Phase II- Metabolic Detoxication, Phase II
- Metabolic Detoxication, Conjugative
- Conjugative Metabolic Detoxication
- Conjugative Metabolic Detoxications
- Detoxication, Conjugative Metabolic
- Detoxications, Conjugative Metabolic
- Metabolic Detoxications, Conjugative
- Phase II Detoxification
- Detoxification, Phase II
- Detoxifications, Phase II
- Phase II Detoxifications
- Metabolic Detoxification, Phase II
Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase II".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase II".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase II" by people in Harvard Catalyst Profiles by year, and whether "Metabolic Detoxication, Phase II" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
Below are the most recent publications written about "Metabolic Detoxication, Phase II" by people in Profiles.
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Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population. Mol Biol Rep. 2020 Jan; 47(1):393-400.
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Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection. Drug Metab Dispos. 2014 Jan; 42(1):134-40.
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Nrf2-regulated phase-II detoxification enzymes and phase-III transporters are induced by thyroid hormone in rat liver. Biofactors. 2013 Sep-Oct; 39(5):514-21.
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Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha. Toxicol Sci. 2010 Dec; 118(2):380-90.
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Polymorphisms in phase I and phase II metabolism genes and risk of chronic benzene poisoning in a Chinese occupational population. Carcinogenesis. 2008 Dec; 29(12):2325-9.
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Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes. Ann Oncol. 2007 Sep; 18(9):1523-8.
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Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Carcinogenesis. 2007 Jun; 28(6):1287-93.
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Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16275-80.