Collagen Type VIII

"Collagen Type VIII" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.

Descriptor ID

D024102

MeSH Number(s)

D12.776.860.300.250.400.400

Concept/Terms

Collagen Type VIII

Type VIII Procollagen

Collagen Type-VIII, alpha1 Subunit

Below are MeSH descriptors whose meaning is more general than "Collagen Type VIII".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Scleroproteins [D12.776.860]
Extracellular Matrix Proteins [D12.776.860.300]
Collagen [D12.776.860.300.250]
Non-Fibrillar Collagens [D12.776.860.300.250.400]
Collagen Type VIII [D12.776.860.300.250.400.400]

Below are MeSH descriptors whose meaning is related to "Collagen Type VIII".

Below are MeSH descriptors whose meaning is more specific than "Collagen Type VIII".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Collagen Type VIII" by people in Harvard Catalyst Profiles by year, and whether "Collagen Type VIII" was a major or minor topic of these publication.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	2	0	2
2009	1	2	3
2010	1	1	2
2012	0	1	1
2014	1	0	1
2016	0	1	1
2018	1	0	1
2020	1	0	1

Below are the most recent publications written about "Collagen Type VIII" by people in Profiles.

Functional Impact of Human Genetic Variants of COL18A1/Endostatin on Pulmonary Endothelium. Am J Respir Cell Mol Biol. 2020 04; 62(4):524-534.

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Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1, a Component of Bruch's Membrane. Ophthalmology. 2018 09; 125(9):1433-1443.

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Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients. Matrix Biol. 2017 01; 57-58:55-75.

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Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study. Am J Clin Nutr. 2016 Apr; 103(4):1135-44.

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Three new genetic loci (R1210C in CFH, variants in COL8A1 and RAD51B) are independently related to progression to advanced macular degeneration. PLoS One. 2014; 9(1):e87047.

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The distinct ophthalmic phenotype of Knobloch syndrome in children. Br J Ophthalmol. 2012 Jun; 96(6):890-5.

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Collagen-related genes influence the glaucoma risk factor, central corneal thickness. Hum Mol Genet. 2011 Feb 15; 20(4):649-58.

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Distribution of COL8A2 and COL8A1 gene variants in Caucasian primary open angle glaucoma patients with thin central corneal thickness. Mol Vis. 2010 Oct 29; 16:2185-91.

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Unusual presentation of presumed posterior polymorphous dystrophy associated with iris heterochromia, band keratopathy, and keratoconus. Cornea. 2010 Oct; 29(10):1180-5.

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Hemostatic consequences of a non-fresh or reconstituted whole blood small volume cardiopulmonary bypass prime in neonates and infants. Paediatr Anaesth. 2009 Sep; 19(9):854-61.

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