Leukotriene B4

"Leukotriene B4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)

Descriptor ID

D007975

MeSH Number(s)

D10.251.355.255.100.450.411

D23.469.050.175.450.415

Concept/Terms

Leukotriene B4

Leukotrienes B

5,12-diHETE

Below are MeSH descriptors whose meaning is more general than "Leukotriene B4".

Chemicals and Drugs [D]
Lipids [D10]
Fatty Acids [D10.251]
Fatty Acids, Unsaturated [D10.251.355]
Eicosanoids [D10.251.355.255]
Arachidonic Acids [D10.251.355.255.100]
Leukotrienes [D10.251.355.255.100.450]
Leukotriene B4 [D10.251.355.255.100.450.411]
Biological Factors [D23]
Inflammation Mediators [D23.469]
Autacoids [D23.469.050]
Eicosanoids [D23.469.050.175]
Leukotrienes [D23.469.050.175.450]
Leukotriene B4 [D23.469.050.175.450.415]

Below are MeSH descriptors whose meaning is related to "Leukotriene B4".

Below are MeSH descriptors whose meaning is more specific than "Leukotriene B4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leukotriene B4" by people in Harvard Catalyst Profiles by year, and whether "Leukotriene B4" was a major or minor topic of these publication.

Bar chart showing 116 publications over 30 distinct years, with a maximum of 7 publications in 2001 and 2011 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	1	2	3
1996	2	2	4
1997	1	1	2
1998	0	3	3
1999	2	3	5
2000	2	4	6
2001	2	5	7
2002	0	3	3
2003	3	3	6
2004	1	3	4
2005	2	3	5
2006	4	1	5
2007	0	4	4
2008	0	2	2
2009	1	1	2
2010	3	2	5
2011	2	5	7
2012	1	5	6
2013	1	3	4
2014	4	3	7
2015	1	1	2
2016	1	1	2
2017	3	3	6
2018	3	2	5
2019	0	1	1
2020	1	2	3
2021	1	2	3
2022	0	1	1
2023	2	0	2

Below are the most recent publications written about "Leukotriene B4" by people in Profiles.

NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2303814120.

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ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production. Front Immunol. 2022; 13:1067885.

View in: PubMed
Isoflurane attenuates sepsis-associated lung injury. Biochem Biophys Res Commun. 2022 04 09; 599:127-133.

View in: PubMed
Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021 06 18; 372(6548).

View in: PubMed
Dual inhibition of complement component 5 and leukotriene B4 by topical rVA576 in atopic keratoconjunctivis: TRACKER phase 1 clinical trial results. Orphanet J Rare Dis. 2021 06 11; 16(1):270.

View in: PubMed
Regression of human coronary artery plaque is associated with a high ratio of (18-hydroxy-eicosapentaenoic acid + resolvin E1) to leukotriene B4. FASEB J. 2021 04; 35(4):e21448.

View in: PubMed
Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells. Am J Pathol. 2020 09; 190(9):1823-1832.

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The role of propofol hydroxyl group in 5-lipoxygenase recognition. Biochem Biophys Res Commun. 2020 05 14; 525(4):909-914.

View in: PubMed
Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach. Infect Immun. 2020 02 20; 88(3).

View in: PubMed
Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making. Front Immunol. 2019; 10:359.

View in: PubMed

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