Jumonji Domain-Containing Histone Demethylases
"Jumonji Domain-Containing Histone Demethylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.
MeSH Number(s)
D08.811.682.662.582.475.500
D08.811.682.690.416.388
Below are MeSH descriptors whose meaning is more general than "Jumonji Domain-Containing Histone Demethylases".
Below are MeSH descriptors whose meaning is more specific than "Jumonji Domain-Containing Histone Demethylases".
This graph shows the total number of publications written about "Jumonji Domain-Containing Histone Demethylases" by people in Harvard Catalyst Profiles by year, and whether "Jumonji Domain-Containing Histone Demethylases" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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2005 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2007 | 0 | 4 | 4 |
2008 | 0 | 1 | 1 |
2009 | 1 | 1 | 2 |
2010 | 1 | 2 | 3 |
2011 | 3 | 3 | 6 |
2012 | 2 | 4 | 6 |
2013 | 4 | 1 | 5 |
2014 | 6 | 1 | 7 |
2015 | 5 | 2 | 7 |
2016 | 6 | 2 | 8 |
2017 | 5 | 6 | 11 |
2018 | 8 | 2 | 10 |
2019 | 3 | 5 | 8 |
2020 | 3 | 4 | 7 |
2021 | 3 | 4 | 7 |
2022 | 2 | 2 | 4 |
2023 | 0 | 3 | 3 |
2024 | 0 | 1 | 1 |
Below are the most recent publications written about "Jumonji Domain-Containing Histone Demethylases" by people in Profiles.
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Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer. J Immunother Cancer. 2024 Feb 02; 12(2).
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Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation. Epigenetics Chromatin. 2023 10 16; 16(1):39.
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Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell. 2023 10 12; 186(21):4528-4545.e18.
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Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer's disease. Commun Biol. 2023 05 15; 6(1):503.
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Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 07 13; 14(653):eabq2096.
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An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma. Mol Cell. 2022 08 18; 82(16):3030-3044.e8.
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Histone demethylase KDM4C is a functional dependency in JAK2-mutated neoplasms. Leukemia. 2022 07; 36(7):1843-1849.
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H3K27me3 Demethylase UTX Restrains Plasma Cell Formation. J Immunol. 2022 04 15; 208(8):1873-1885.
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A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proc Natl Acad Sci U S A. 2022 03 01; 119(9).
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The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies. Biomolecules. 2021 12 20; 11(12).