Harvard Catalyst Profiles

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Below are MeSH descriptors whose meaning is more general than "Pyruvate Dehydrogenase Complex".

Below are MeSH descriptors whose meaning is related to "Pyruvate Dehydrogenase Complex".

Below are MeSH descriptors whose meaning is more specific than "Pyruvate Dehydrogenase Complex".