Harvard Catalyst Profiles

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.

Below are MeSH descriptors whose meaning is more general than "Dideoxyadenosine".

Below are MeSH descriptors whose meaning is related to "Dideoxyadenosine".

Below are MeSH descriptors whose meaning is more specific than "Dideoxyadenosine".