Cantharidin

"Cantharidin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.

Descriptor ID

D002193

MeSH Number(s)

D03.438.127.125

Concept/Terms

Cantharidin

Cantharides

Below are MeSH descriptors whose meaning is more general than "Cantharidin".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 2-Ring [D03.438]
Benzofurans [D03.438.127]
Cantharidin [D03.438.127.125]

Below are MeSH descriptors whose meaning is related to "Cantharidin".

Below are MeSH descriptors whose meaning is more specific than "Cantharidin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cantharidin" by people in Harvard Catalyst Profiles by year, and whether "Cantharidin" was a major or minor topic of these publication.

Bar chart showing 2 publications over 2 distinct years, with a maximum of 1 publications in 1996 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
2014	1	0	1

Below are the most recent publications written about "Cantharidin" by people in Profiles.

Cantharidin Attenuates the Proliferation and Migration of Vascular Smooth Muscle Cells through Suppressing Inflammatory Response. Biol Pharm Bull. 2019 Jan 01; 42(1):34-42.

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Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. Int J Dermatol. 2018 Aug; 57(8):1001-1006.

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Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem Pharmacol. 2016 06 01; 109:14-26.

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Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. J Dent Res. 2015 Feb; 94(2):320-9.

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Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation: clinical and genetic characterization and target for therapy. Brain. 2014 Apr; 137(Pt 4):1019-29.

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Treatment of porokeratosis of Mibelli with cantharidin. J Am Acad Dermatol. 2013 Nov; 69(5):e254-e255.

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Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. J Cell Sci. 2012 Dec 15; 125(Pt 24):5974-83.

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Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway. Cancer Sci. 2008 Sep; 99(9):1820-6.

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Childhood molluscum contagiosum: experience with cantharidin therapy in 300 patients. J Am Acad Dermatol. 2000 Sep; 43(3):503-7.

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Local spread of molluscum contagiosum by electrolysis. Clin Infect Dis. 1999 May; 28(5):1171.

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