Elafin

"Elafin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A secretory proteinase inhibitory protein that was initially purified from human SKIN. It is found in a variety mucosal secretions and is present at high levels in SPUTUM. Elafin may play a role in the innate immunity (IMMUNITY, INNATE) response of the LUNG.

Descriptor ID

D053492

MeSH Number(s)

D12.644.822.437

D12.776.645.437

Concept/Terms

Elafin

Below are MeSH descriptors whose meaning is more general than "Elafin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Proteinase Inhibitory Proteins, Secretory [D12.644.822]
Elafin [D12.644.822.437]
Proteins [D12.776]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Elafin [D12.776.645.437]

Below are MeSH descriptors whose meaning is related to "Elafin".

Below are MeSH descriptors whose meaning is more specific than "Elafin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Elafin" by people in Harvard Catalyst Profiles by year, and whether "Elafin" was a major or minor topic of these publication.

Bar chart showing 19 publications over 10 distinct years, with a maximum of 4 publications in 2009 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2009	4	0	4
2010	1	0	1
2012	1	1	2
2013	0	1	1
2014	4	0	4
2015	2	0	2
2017	1	0	1
2021	0	1	1
2022	1	1	2

Below are the most recent publications written about "Elafin" by people in Profiles.

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022 10 15; 206(8):1019-1034.

View in: PubMed
Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data. BMC Med. 2022 10 05; 20(1):353.

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Evaluation of Elafin as a Prognostic Biomarker in Acute Graft-versus-Host Disease. Transplant Cell Ther. 2021 12; 27(12):988.e1-988.e7.

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Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study. Shock. 2017 08; 48(2):168-174.

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Elafin in pulmonary arterial hypertension. Beyond targeting elastases. Am J Respir Crit Care Med. 2015 Jun 01; 191(11):1217-9.

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Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. Am J Transplant. 2015 Jul; 15(7):1768-81.

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Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):262-72.

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Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. Cancer Discov. 2014 Aug; 4(8):896-904.

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Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015 Jan 15; 34(3):373-83.

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Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence. Breast Cancer Res. 2014; 16(6):3417.

View in: PubMed

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