Helper Viruses

"Helper Viruses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Viruses which enable defective viruses to replicate or to form a protein coat by complementing the missing gene function of the defective (satellite) virus. Helper and satellite may be of the same or different genus.

Descriptor ID

D006378

MeSH Number(s)

B04.423

Concept/Terms

Helper Viruses

Below are MeSH descriptors whose meaning is more general than "Helper Viruses".

Organisms [B]
Viruses [B04]
Helper Viruses [B04.423]

Below are MeSH descriptors whose meaning is related to "Helper Viruses".

Below are MeSH descriptors whose meaning is more specific than "Helper Viruses".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Helper Viruses" by people in Harvard Catalyst Profiles by year, and whether "Helper Viruses" was a major or minor topic of these publication.

Bar chart showing 22 publications over 11 distinct years, with a maximum of 4 publications in 2001 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	1	0	1
1999	0	1	1
2000	2	1	3
2001	3	1	4
2002	2	0	2
2003	2	0	2
2004	0	2	2
2010	1	3	4
2011	0	1	1
2013	0	1	1

Below are the most recent publications written about "Helper Viruses" by people in Profiles.

De novo generation of helper virus-satellite chimera RNAs results in disease attenuation and satellite sequence acquisition in a host-dependent manner. Virology. 2018 01 15; 514:182-191.

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Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression. Gene Ther. 2015 Nov; 22(11):856-65.

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Differential type I interferon-dependent transgene silencing of helper-dependent adenoviral vs. adeno-associated viral vectors in vivo. Mol Ther. 2013 Apr; 21(4):796-805.

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NOD2 signaling contributes to the innate immune response against helper-dependent adenovirus vectors independently of MyD88 in vivo. Hum Gene Ther. 2011 Sep; 22(9):1071-82.

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Satellite phage TLCf enables toxigenic conversion by CTX phage through dif site alteration. Nature. 2010 Oct 21; 467(7318):982-5.

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Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale. Hum Gene Ther. 2010 Oct; 21(10):1259-71.

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Antibody-mediated targeted gene transfer to NMDA NR1-containing neurons in rat neocortex by helper virus-free HSV-1 vector particles containing a chimeric HSV-1 glycoprotein C-staphylococcus A protein. Brain Res. 2010 Sep 10; 1351:1-12.

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Targeting HSV-1 virions for specific binding to epidermal growth factor receptor-vIII-bearing tumor cells. Cancer Gene Ther. 2010 Sep; 17(9):655-63.

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A helper virus-free HSV-1 vector containing the vesicular glutamate transporter-1 promoter supports expression preferentially in VGLUT1-containing glutamatergic neurons. Brain Res. 2010 May 17; 1331:12-9.

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MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to helper-dependent adenovirus. Hum Gene Ther. 2010 Mar; 21(3):325-36.

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