"Codon, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A codon that directs initiation of protein translation (TRANSLATION, GENETIC) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.
MeSH Number(s)
D13.444.735.544.355.225
G05.360.335.355.225
G05.360.340.024.340.137.190.225
Concept/Terms
Codon, Initiator- Codon, Initiator
- Codons, Initiator
- Initiator Codons
- Initiator Codon
- Start Codon
- Codon, Start
- Codons, Start
- Start Codons
- Codon, Initiation
- Codons, Initiation
- Initiation Codon
- Initiation Codons
Below are MeSH descriptors whose meaning is more general than "Codon, Initiator".
Below are MeSH descriptors whose meaning is more specific than "Codon, Initiator".
This graph shows the total number of publications written about "Codon, Initiator" by people in Harvard Catalyst Profiles by year, and whether "Codon, Initiator" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 3 | 4 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2018 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Codon, Initiator" by people in Profiles.
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A paradoxical genotype-phenotype relationship: Low level of GOSR2 translation from a non-AUG start codon in a family with profound hearing loss. Hum Mol Genet. 2023 07 04; 32(14):2265-2268.
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New Mechanism of Acyclovir Resistance in Herpes Simplex Virus 1, Which Has a UAG Stop Codon between the First and Second AUG Initiation Codons. Jpn J Infect Dis. 2020 Nov 24; 73(6):447-451.
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Multifaceted deregulation of gene expression and protein synthesis with age. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15581-15590.
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Comprehensive profiling of translation initiation in influenza virus infected cells. PLoS Pathog. 2019 01; 15(1):e1007518.
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Accessibility of the Shine-Dalgarno Sequence Dictates N-Terminal Codon Bias in E. coli. Mol Cell. 2018 06 07; 70(5):894-905.e5.
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Two Angelman families with unusually advanced neurodevelopment carry a start codon variant in the most highly expressed UBE3A isoform. Am J Med Genet A. 2018 07; 176(7):1641-1647.
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Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P. Nucleic Acids Res. 2017 Dec 15; 45(22):13004-13015.
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Interface between 40S exit channel protein uS7/Rps5 and eIF2a modulates start codon recognition in vivo. Elife. 2017 02 07; 6.
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Comprehensive identification of translation start sites by tetracycline-inhibited ribosome profiling. DNA Res. 2016 Jun; 23(3):193-201.
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Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons. J Biol Chem. 2016 May 13; 291(20):10824-35.