Fanconi Anemia Complementation Group L Protein
"Fanconi Anemia Complementation Group L Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 UBIQUITIN LIGASE that plays a key role in the DNA damage response pathway of FANCONI ANEMIA PROTEINS. It is associated with mono-ubiquitination of FANCD2 PROTEIN and the redistribution of FANCD2 to nuclear foci containing BRCA1 PROTEIN.
MeSH Number(s)
D08.811.464.938.750.186
D12.776.313.937
Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia Complementation Group L Protein".
Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia Complementation Group L Protein".
This graph shows the total number of publications written about "Fanconi Anemia Complementation Group L Protein" by people in Harvard Catalyst Profiles by year, and whether "Fanconi Anemia Complementation Group L Protein" was a major or minor topic of these publication.
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Year | Major Topic | Minor Topic | Total |
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2006 | 1 | 1 | 2 |
2011 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
Below are the most recent publications written about "Fanconi Anemia Complementation Group L Protein" by people in Profiles.
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Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016 11 24; 35(47):6087-6095.
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The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem. 2014 Mar 07; 289(10):7003-7010.
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Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011 Oct; 131(10):2139-42.
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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell. 2006 Aug; 23(4):589-96.
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Drosophila homologs of FANCD2 and FANCL function in DNA repair. DNA Repair (Amst). 2006 Nov 08; 5(11):1317-26.
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The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem. 2006 Apr 21; 281(16):10896-905.