3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
"3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
MeSH Number(s)
D03.383.725.203.600
D03.383.725.547.900
Concept/Terms
Bay-R-5417- Bay-R-5417
- Bay R 5417
- BayR5417
- Bay R5417
- R5417, Bay
Bay-K-8644- Bay-K-8644
- Bay K 8644
- BayK8644
- BK-8644
- BK 8644
- BK8644
- Bay-K8644
- Bay K8644
Below are MeSH descriptors whose meaning is more general than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
Below are MeSH descriptors whose meaning is more specific than "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester".
This graph shows the total number of publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in Harvard Catalyst Profiles by year, and whether "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 1 | 2 | 3 |
| 1996 | 1 | 2 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2012 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
Below are the most recent publications written about "3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester" by people in Profiles.
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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation. Cancer Cell. 2019 05 13; 35(5):767-781.e6.
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Turtle Flexion Reflex Motor Patterns Show Windup, Mediated Partly by L-type Calcium Channels. Front Neural Circuits. 2017; 11:83.
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Dynamics of early afterdepolarization-mediated triggered activity in cardiac monolayers. Biophys J. 2012 Jun 20; 102(12):2706-14.
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Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium. J Ethnopharmacol. 2011 Nov 18; 138(2):382-9.
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Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels. J Neurophysiol. 2011 Dec; 106(6):2922-35.
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Screening for calcium channel modulators in CLN3 siRNA knock down SH-SY5Y neuroblastoma cells reveals a significant decrease of intracellular calcium levels by selected L-type calcium channel blockers. Biochim Biophys Acta. 2011 Feb; 1810(2):186-91.
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A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR. J Gen Physiol. 2010 Jun; 135(6):619-28.
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A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels. J Gen Physiol. 2010 Jun; 135(6):629-40.
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TGF-beta1 calcium signaling in osteoblasts. J Cell Biochem. 2007 May 15; 101(2):348-59.
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Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation. Circ Res. 2006 Sep 29; 99(7):749-57.