"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
Concept/Terms
Metformin- Metformin
- Dimethylguanylguanidine
- Dimethylbiguanidine
Below are MeSH descriptors whose meaning is more general than "Metformin".
Below are MeSH descriptors whose meaning is more specific than "Metformin".
This graph shows the total number of publications written about "Metformin" by people in Harvard Catalyst Profiles by year, and whether "Metformin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1996 | 2 | 1 | 3 |
1998 | 0 | 1 | 1 |
1999 | 2 | 1 | 3 |
2000 | 2 | 2 | 4 |
2001 | 2 | 0 | 2 |
2002 | 3 | 2 | 5 |
2003 | 2 | 6 | 8 |
2004 | 6 | 3 | 9 |
2005 | 4 | 5 | 9 |
2006 | 1 | 5 | 6 |
2007 | 6 | 7 | 13 |
2008 | 3 | 10 | 13 |
2009 | 11 | 6 | 17 |
2010 | 7 | 6 | 13 |
2011 | 6 | 3 | 9 |
2012 | 10 | 13 | 23 |
2013 | 14 | 12 | 26 |
2014 | 22 | 12 | 34 |
2015 | 23 | 6 | 29 |
2016 | 26 | 11 | 37 |
2017 | 24 | 20 | 44 |
2018 | 15 | 16 | 31 |
2019 | 25 | 11 | 36 |
2020 | 26 | 9 | 35 |
2021 | 22 | 5 | 27 |
2022 | 29 | 1 | 30 |
2023 | 32 | 0 | 32 |
2024 | 2 | 0 | 2 |
Below are the most recent publications written about "Metformin" by people in Profiles.
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Growth Hormone Mediators and Glycemic Control in Youths With Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 Feb 05; 7(2):e240447.
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Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice. Stem Cell Res Ther. 2024 01 08; 15(1):13.
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Human trials exploring anti-aging medicines. Cell Metab. 2024 Feb 06; 36(2):354-376.
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Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma. Neuro Oncol. 2023 12 08; 25(12):2165-2176.
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Metformin Does not Affect Outcomes in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Therapy and Resection. Am Surg. 2024 Apr; 90(4):858-865.
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Investigating the ability to adhere to cardiometabolic medications with different properties: a retrospective cohort study of >500 000 patients in the USA. BMJ Open. 2023 11 10; 13(11):e075840.
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Efficacy and safety of metformin during pregnancy: an update. Endocrine. 2024 Feb; 83(2):259-269.
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Medical Therapy Before, During and After Hospitalization in Medicare Beneficiaries With Heart Failure and Diabetes: Get With The Guidelines - Heart Failure Registry. J Card Fail. 2024 Feb; 30(2):319-328.
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The effect of starting metformin on bone mineral density among women with type 2 diabetes in the Study of Women's Health Across the Nation (SWAN). Osteoporos Int. 2024 Jan; 35(1):189-194.
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Effect of Metformin Versus Placebo on New Primary Cancers in Canadian Cancer Trials Group MA.32: A Secondary Analysis of a Phase III Randomized Double-Blind Trial in Early Breast Cancer. J Clin Oncol. 2023 Dec 10; 41(35):5356-5362.