Harvard Catalyst Profiles

An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)

Below are MeSH descriptors whose meaning is more general than "Leukoencephalopathy, Progressive Multifocal".

Below are MeSH descriptors whose meaning is related to "Leukoencephalopathy, Progressive Multifocal".

Below are MeSH descriptors whose meaning is more specific than "Leukoencephalopathy, Progressive Multifocal".