Hydroxymethylglutaryl-CoA Synthase

"Hydroxymethylglutaryl-CoA Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-CoA. This is a key enzyme in steroid biosynthesis. This enzyme was formerly listed as EC 4.1.3.5.

Descriptor ID

D006904

MeSH Number(s)

D08.811.913.050.612

Concept/Terms

Hydroxymethylglutaryl-CoA Synthase

Below are MeSH descriptors whose meaning is more general than "Hydroxymethylglutaryl-CoA Synthase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Hydroxymethylglutaryl-CoA Synthase [D08.811.913.050.612]

Below are MeSH descriptors whose meaning is related to "Hydroxymethylglutaryl-CoA Synthase".

Below are MeSH descriptors whose meaning is more specific than "Hydroxymethylglutaryl-CoA Synthase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in Harvard Catalyst Profiles by year, and whether "Hydroxymethylglutaryl-CoA Synthase" was a major or minor topic of these publication.

Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1998 and 2010 and 2011 and 2012 and 2015 and 2019 and 2020 and 2021 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2010	1	0	1
2011	1	0	1
2012	0	1	1
2015	0	1	1
2019	0	1	1
2020	0	1	1
2021	0	1	1
2023	0	1	1

Below are the most recent publications written about "Hydroxymethylglutaryl-CoA Synthase" by people in Profiles.

Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress. Front Immunol. 2023; 14:1185517.

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TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination. J Cell Biol. 2021 09 06; 220(9).

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A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export. Nat Commun. 2020 11 03; 11(1):5559.

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Association of a novel homozygous mutation in the HMGCS2 gene with an HMGCSD in an Iranian patient. Mol Genet Genomic Med. 2020 11; 8(11):e1507.

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Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 2019 08 22; 178(5):1115-1131.e15.

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HMGCS2 enhances invasion and metastasis via direct interaction with PPARa to activate Src signaling in colorectal cancer and oral cancer. Oncotarget. 2017 Apr 04; 8(14):22460-22476.

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mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy. Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52):15790-7.

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Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):E3880-9.

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Elevated FGF21 secretion, PGC-1a and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle. Hum Mol Genet. 2014 Jan 01; 23(1):24-39.

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Statins, inflammation and deep vein thrombosis: a systematic review. J Thromb Thrombolysis. 2012 May; 33(4):371-82.

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