"Microsomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Below are MeSH descriptors whose meaning is more general than "Microsomes".
Below are MeSH descriptors whose meaning is more specific than "Microsomes".
This graph shows the total number of publications written about "Microsomes" by people in Harvard Catalyst Profiles by year, and whether "Microsomes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 4 | 7 | 11 |
| 1995 | 1 | 6 | 7 |
| 1996 | 4 | 6 | 10 |
| 1997 | 1 | 3 | 4 |
| 1998 | 3 | 7 | 10 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 8 | 8 |
| 2001 | 1 | 5 | 6 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 3 | 3 |
| 2005 | 1 | 2 | 3 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
Below are the most recent publications written about "Microsomes" by people in Profiles.
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Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. Int J Mol Sci. 2021 May 08; 22(9).
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Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors. J Med Chem. 2020 12 24; 63(24):15821-15851.
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Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 09 26; 62(18):8557-8577.
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Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes. J Labelled Comp Radiopharm. 2019 05 15; 62(5):202-208.
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Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg Med Chem Lett. 2018 02 15; 28(4):762-768.
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Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. ACS Chem Biol. 2017 12 15; 12(12):3126-3133.
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K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016 08; 90(2):106-15.
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Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression. Oncotarget. 2015 Nov 24; 6(37):39941-59.
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Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability. Bioorg Med Chem Lett. 2015 Sep 15; 25(18):3956-60.
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Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. PLoS One. 2015; 10(7):e0132604.