D007506Chemicals & DrugsD12.776.157.427.374.375D12.776.556.579.374.37561830.941644Iron-Sulfur Proteinscatalyst:eCommonsLogineCommons LoginFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:meshTreeNumberMeSH tree numberprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierDepartmentDivisionvivo:hrJobTitleHR job titleInformation ResourcePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:researchAreaOfresearch area ofvivo:subjectAreaForsubject area forrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson2.050420.01072161research area of0.9854940.0307704102subject area forNeurologyPediatricsRadiation OncologySystems BiologyBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolMassachusetts General HospitalVKM1VamsiMoothaVamsi Krishna Mootha, M.D.42.36125700000000-71.0655270000000024390Mootha, VamsiProfessor of Systems BiologyJDM39JosephManciasJoseph Douglas Mancias, M.D., Ph.D.42.33510370000000-71.1061649000000018851Mancias, JosephAssistant Professor of Radiation OncologyPAS1PamelaSilverPamela A. Silver, Ph.D.42.33594500000000-71.1029580000000033128Silver, PamelaElliott T. and Onie H. Adams Professor of Biochemistry and Systems Biologytrue1Assistant Professor of Radiation OncologyAssistant Professor of Radiation Oncologytrue1Elliott T. and Onie H. Adams Professor of Biochemistry and Systems BiologyElliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology35771492Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE, Chen B, Das NK, Lowder KE, Hennessey CJ, Huang W, Yang A, Shah YM, Nowak JA, Aguirre AJ, Mancias JDCancer discoveryNCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins. Cancer Discov. 2022 09 02; 12(9):2180-2197.Cancer Discov2022-09-02T00:00:002022NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins.35771494Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RMCancer discoveryCoordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer. Cancer Discov. 2022 09 02; 12(9):2198-2219.Cancer Discov2022-09-02T00:00:002022Coordinated Transcriptional and Catabolic Programs Support Iron-Dependent Adaptation to RAS-MAPK Pathway Inhibition in Pancreatic Cancer.mac8821MayaChopraMaya Chopra, M.B.,B.S.211944Chopra, MayaAssistant Professor of Neurology35590056Chopra M, Caswell R, Barcia G, Rondeau S, Jonard L, Nitchké P, Amram D, Bellaiche ML, Abadie V, Parodi M, Denoyelle F, Hattersley A, Bole C, Lyonnet S, Marlin SEuropean journal of human genetics : EJHGMild MDPL in a patient with a novel de novo missense variant in the Cys-B region of POLD1. Eur J Hum Genet. 2022 08; 30(8):960-966.Eur J Hum Genet2022-05-20T00:00:002022Mild MDPL in a patient with a novel de novo missense variant in the Cys-B region of POLD1.38091389Das M, Sreedharan S, Shee S, Malhotra N, Nandy M, Banerjee U, Kohli S, Rajmani RS, Chandra N, Seshasayee ASN, Laxman S, Singh AScience advancesCysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence. Sci Adv. 2023 Dec 15; 9(50):eadh2858.Sci Adv2023-12-13T00:00:002023Cysteine desulfurase (IscS)-mediated fine-tuning of bioenergetics and SUF expression prevents Mycobacterium tuberculosis hypervirulence.NancyAndrewsNancy Catherine Andrews, M.D., Ph.D.41939Andrews, NancyProfessor in Residence of Pediatrics38199006Ast T, Itoh Y, Sadre S, McCoy JG, Namkoong G, Wengrod JC, Chicherin I, Joshi PR, Kamenski P, Suess DLM, Amunts A, Mootha VKMolecular cellMETTL17 is an Fe-S cluster checkpoint for mitochondrial translation. Mol Cell. 2024 Jan 18; 84(2):359-374.e8.Mol Cell2024-01-09T00:00:002024METTL17 is an Fe-S cluster checkpoint for mitochondrial translation.true1Professor of Systems BiologyProfessor of Systems Biologytrue1Professor in Residence of PediatricsProfessor in Residence of Pediatricstrue1Assistant Professor of NeurologyAssistant Professor of Neurology2Assistant Professor0Full Professor