Receptors, Purinergic P2X4
"Receptors, Purinergic P2X4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A widely distributed purinergic P2X receptor subtype that plays a role in pain sensation. P2X4 receptors found on MICROGLIA cells may also play a role in the mediation of allodynia-related NEUROPATHIC PAIN.
MeSH Number(s)
D12.776.157.530.400.400.750.400
D12.776.543.550.425.500.600.400
D12.776.543.585.400.500.600.400
D12.776.543.750.720.700.720.500.400
D12.776.543.750.810.720.500.400
Concept/Terms
Receptors, Purinergic P2X4- Receptors, Purinergic P2X4
- P2X4 Receptors, Purinergic
- Purinergic P2X4 Receptors
- P2X4 Receptor
- Receptor, P2X4
- Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4
- P2X4 Purinoceptor
- Purinoceptor, P2X4
Below are MeSH descriptors whose meaning is more general than "Receptors, Purinergic P2X4".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Receptors, Purinergic P2X [D12.776.157.530.400.400.750]
- Receptors, Purinergic P2X4 [D12.776.157.530.400.400.750.400]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.425]
- Ligand-Gated Ion Channels [D12.776.543.550.425.500]
- Receptors, Purinergic P2X [D12.776.543.550.425.500.600]
- Receptors, Purinergic P2X4 [D12.776.543.550.425.500.600.400]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Receptors, Purinergic P2X [D12.776.543.585.400.500.600]
- Receptors, Purinergic P2X4 [D12.776.543.585.400.500.600.400]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Purinergic [D12.776.543.750.720.700]
- Receptors, Purinergic P2 [D12.776.543.750.720.700.720]
- Receptors, Purinergic P2X [D12.776.543.750.720.700.720.500]
- Receptors, Purinergic P2X4 [D12.776.543.750.720.700.720.500.400]
- Receptors, Purinergic [D12.776.543.750.810]
- Receptors, Purinergic P2 [D12.776.543.750.810.720]
- Receptors, Purinergic P2X [D12.776.543.750.810.720.500]
- Receptors, Purinergic P2X4 [D12.776.543.750.810.720.500.400]
Below are MeSH descriptors whose meaning is more specific than "Receptors, Purinergic P2X4".
This graph shows the total number of publications written about "Receptors, Purinergic P2X4" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Purinergic P2X4" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 2 | 0 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
Below are the most recent publications written about "Receptors, Purinergic P2X4" by people in Profiles.
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P2X4 deficiency reduces atherosclerosis and plaque inflammation in mice. Sci Rep. 2022 02 18; 12(1):2801.
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Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse. J Leukoc Biol. 2021 03; 109(3):497-508.
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PTEN and PHLPP crosstalk in cancer cells and in TGFß-activated stem cells. Biomed Pharmacother. 2020 Jul; 127:110112.
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Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke. Exp Neurol. 2020 07; 329:113308.
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Human Peripheral Blood Eosinophils Express High Levels of the Purinergic Receptor P2X4. Front Immunol. 2019; 10:2074.
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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain. Pain. 2019 09; 160(9):1989-2003.
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Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine. J Physiol. 2019 04; 597(7):1957-1973.
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Purinergic P2X4 receptors and mitochondrial ATP production regulate T cell migration. J Clin Invest. 2018 08 01; 128(8):3583-3594.
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Role of P2X4 Receptor in Mouse Voiding Function. Sci Rep. 2018 01 30; 8(1):1838.
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Toluene diisocyanate: Induction of the autotaxin-lysophosphatidic acid axis and its association with airways symptoms. Toxicol Appl Pharmacol. 2015 Sep 15; 287(3):222-31.