"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
MeSH Number(s)
D02.455.849.291.500.510.700
Concept/Terms
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in Harvard Catalyst Profiles by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 2 | 2 |
1995 | 1 | 1 | 2 |
1996 | 1 | 1 | 2 |
1997 | 2 | 2 | 4 |
1998 | 1 | 1 | 2 |
1999 | 0 | 1 | 1 |
2000 | 0 | 3 | 3 |
2001 | 0 | 2 | 2 |
2006 | 0 | 1 | 1 |
Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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NFATc3 promotes Ca(2+) -dependent MMP3 expression in astroglial cells. Glia. 2013 Jul; 61(7):1052-66.
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Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice. PLoS One. 2012; 7(11):e48507.
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Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1976-82.
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Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries. J Comp Physiol B. 2010 Mar; 180(3):427-35.
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Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response. Cell Stress Chaperones. 2008 Dec; 13(4):421-34.
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Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells. Free Radic Biol Med. 2008 Apr 15; 44(8):1656-67.
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Rapid modulation of micro-opioid receptor signaling in primary sensory neurons. J Pharmacol Exp Ther. 2007 Jun; 321(3):839-47.
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Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells. Exp Cell Res. 2007 Mar 10; 313(5):849-66.
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Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering. Immunity. 2006 Aug; 25(2):297-308.
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Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C. Acta Biochim Pol. 2004; 51(3):757-72.