Secretory Leukocyte Peptidase Inhibitor

"Secretory Leukocyte Peptidase Inhibitor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proteinase inhibitor found in various BODILY SECRETIONS that coat mucosal surfaces such as SEMINAL PLASMA; CERVICAL MUCUS; and bronchial secretions. It plays a role in protecting epithelial tissues from LEUKOCYTE-derived serine proteases such as NEUTROPHIL ELASTASE.

Descriptor ID

D053481

MeSH Number(s)

D12.644.822.500

D12.776.645.500

Concept/Terms

Secretory Leukocyte Peptidase Inhibitor

Below are MeSH descriptors whose meaning is more general than "Secretory Leukocyte Peptidase Inhibitor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Proteinase Inhibitory Proteins, Secretory [D12.644.822]
Secretory Leukocyte Peptidase Inhibitor [D12.644.822.500]
Proteins [D12.776]
Proteinase Inhibitory Proteins, Secretory [D12.776.645]
Secretory Leukocyte Peptidase Inhibitor [D12.776.645.500]

Below are MeSH descriptors whose meaning is related to "Secretory Leukocyte Peptidase Inhibitor".

Below are MeSH descriptors whose meaning is more specific than "Secretory Leukocyte Peptidase Inhibitor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Secretory Leukocyte Peptidase Inhibitor" by people in Harvard Catalyst Profiles by year, and whether "Secretory Leukocyte Peptidase Inhibitor" was a major or minor topic of these publication.

Bar chart showing 17 publications over 11 distinct years, with a maximum of 3 publications in 2013 and 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	0	1	1
2007	1	0	1
2008	0	1	1
2009	1	1	2
2011	1	0	1
2013	2	1	3
2014	0	1	1
2016	1	2	3
2018	1	0	1
2020	1	1	2

Below are the most recent publications written about "Secretory Leukocyte Peptidase Inhibitor" by people in Profiles.

Non-genetic determinants of malignant clonal fitness at single-cell resolution. Nature. 2022 01; 601(7891):125-131.

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Neutrophil elastase and endogenous inhibitors in Behçet's disease saliva. Clin Exp Immunol. 2020 10; 202(1):93-105.

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Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age. PLoS One. 2020; 15(1):e0224359.

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SLPI: a new target for stopping metastasis. Aging (Albany NY). 2018 Jan 20; 10(1):13-14.

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Secretory Leukocyte Protease Inhibitor Expression and High-Risk HPV Infection in Anal Lesions of HIV-Positive Patients. J Acquir Immune Defic Syndr. 2016 09 01; 73(1):27-33.

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Secretory leukocyte protease inhibitor is a survival and proliferation factor for castration-resistant prostate cancer. Oncogene. 2016 09 08; 35(36):4807-15.

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Biomarkers of Cervical Inflammation and Immunity Associated with Cervical Shedding of HIV-1. AIDS Res Hum Retroviruses. 2016 May; 32(5):443-51.

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Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1. J Immunol. 2016 Feb 15; 196(4):1922-32.

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Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection. J Gen Virol. 2016 Feb; 97(2):422-434.

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High IFN-? and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015 Aug 03; 125(8):3037-50.

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