Ribonucleoprotein, U4-U6 Small Nuclear
"Ribonucleoprotein, U4-U6 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
MeSH Number(s)
D12.776.157.725.500.875.615
D12.776.664.962.500.875.615
Concept/Terms
Ribonucleoprotein, U4-U6 Small Nuclear- Ribonucleoprotein, U4-U6 Small Nuclear
- Ribonucleoprotein, U4 U6 Small Nuclear
- Ribonucleoproteins, Small, U4-U6
- U4-U6 Small Nuclear Ribonucleoproteins
- U4 U6 Small Nuclear Ribonucleoproteins
- U4-U6 snRNP
- Small Nuclear Ribonucleoproteins, U4-U6
- Small Nuclear Ribonucleoproteins, U4 U6
U6 snRNP- U6 snRNP
- U6 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U6 Small Nuclear
- Small Nuclear Ribonucleoproteins, U6
U4 snRNP- U4 snRNP
- U4 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U4 Small Nuclear
- Small Nuclear Ribonucleoproteins, U4
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U4-U6 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U4-U6 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in Harvard Catalyst Profiles by year, and whether "Ribonucleoprotein, U4-U6 Small Nuclear" was a major or minor topic of these publication.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in Profiles.
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Haploinsufficient tumor suppressor PRP4K is negatively regulated during epithelial-to-mesenchymal transition. FASEB J. 2021 11; 35(11):e22001.
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Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation. PLoS Genet. 2016 Jan; 12(1):e1005768.
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Mutations in pre-mRNA processing factors 3, 8, and 31 cause dysfunction of the retinal pigment epithelium. Am J Pathol. 2014 Oct; 184(10):2641-52.
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Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa. Mol Vis. 2014; 20:843-51.
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Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex. Cell Res. 2014 Apr; 24(4):497-500.
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Post-transcriptional modifications modulate conformational dynamics in human U2-U6 snRNA complex. RNA. 2014 Jan; 20(1):16-23.
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SmD3 regulates intronic noncoding RNA biogenesis. Mol Cell Biol. 2012 Oct; 32(20):4092-103.
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Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Nature. 2011 May 26; 473(7348):536-9.
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PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Hum Mol Genet. 2011 Jun 01; 20(11):2116-30.
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Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP. PLoS One. 2011 Jan 19; 6(1):e15860.