"Epilepsy, Tonic-Clonic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
Concept/Terms
Epilepsy, Tonic-Clonic- Epilepsy, Tonic-Clonic
- Epilepsies, Tonic-Clonic
- Epilepsy, Tonic Clonic
- Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsy
- Epilepsy, Grand Mal
- Grand Mal Epilepsy
- Epilepsy, Major
- Major Epilepsies
- Major Epilepsy
- Grand Mal Seizure Disorder
- Major Motor Seizure Disorder
- Tonic-Clonic Seizure Syndrome
- Seizure Syndrome, Tonic-Clonic
- Seizure Syndromes, Tonic-Clonic
- Syndrome, Tonic-Clonic Seizure
- Syndromes, Tonic-Clonic Seizure
- Tonic Clonic Seizure Syndrome
- Tonic-Clonic Seizure Syndromes
- Seizure Disorder, Major Motor
- Seizure Disorder, Tonic Clonic
- Tonic Clonic Convulsions
- Convulsion, Tonic Clonic
- Convulsions, Tonic Clonic
- Tonic Clonic Convulsion
- Tonic-Clonic Convulsion Disorder
- Convulsion Disorder, Tonic-Clonic
- Convulsion Disorders, Tonic-Clonic
- Disorder, Tonic-Clonic Convulsion
- Disorders, Tonic-Clonic Convulsion
- Tonic Clonic Convulsion Disorder
- Tonic-Clonic Convulsion Disorders
- Tonic-Clonic Convulsion Syndrome
- Convulsion Syndrome, Tonic-Clonic
- Convulsion Syndromes, Tonic-Clonic
- Syndrome, Tonic-Clonic Convulsion
- Syndromes, Tonic-Clonic Convulsion
- Tonic Clonic Convulsion Syndrome
- Tonic-Clonic Convulsion Syndromes
- Tonic-Clonic Seizure Disorder
- Disorder, Tonic-Clonic Seizure
- Disorders, Tonic-Clonic Seizure
- Seizure Disorder, Tonic-Clonic
- Seizure Disorders, Tonic-Clonic
- Tonic Clonic Seizure Disorder
- Tonic-Clonic Seizure Disorders
- Convulsions, Grand Mal
- Convulsion, Grand Mal
- Grand Mal Convulsion
- Grand Mal Convulsions
- Seizure Disorder, Grand Mal
Epilepsy, Tonic-Clonic, Symptomatic- Epilepsy, Tonic-Clonic, Symptomatic
- Symptomatic Tonic-Clonic Epilepsy
- Epilepsies, Symptomatic Tonic-Clonic
- Epilepsy, Symptomatic Tonic-Clonic
- Symptomatic Tonic Clonic Epilepsy
- Symptomatic Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsies, Symptomatic
- Tonic-Clonic Epilepsy, Symptomatic
Cryptogenic Tonic-Clonic Epilepsy- Cryptogenic Tonic-Clonic Epilepsy
- Cryptogenic Tonic Clonic Epilepsy
- Cryptogenic Tonic-Clonic Epilepsies
- Epilepsies, Cryptogenic Tonic-Clonic
- Epilepsy, Cryptogenic Tonic-Clonic
- Tonic-Clonic Epilepsies, Cryptogenic
- Tonic-Clonic Epilepsy, Cryptogenic
- Epilepsy, Tonic-Clonic, Cryptogenic
Epilepsy, Tonic-Clonic, Familial- Epilepsy, Tonic-Clonic, Familial
- Familial Tonic-Clonic Epilepsy
- Epilepsies, Familial Tonic-Clonic
- Epilepsy, Familial Tonic-Clonic
- Familial Tonic Clonic Epilepsy
- Familial Tonic-Clonic Epilepsies
- Tonic-Clonic Epilepsies, Familial
- Tonic-Clonic Epilepsy, Familial
Below are MeSH descriptors whose meaning is more general than "Epilepsy, Tonic-Clonic".
Below are MeSH descriptors whose meaning is more specific than "Epilepsy, Tonic-Clonic".
This graph shows the total number of publications written about "Epilepsy, Tonic-Clonic" by people in Harvard Catalyst Profiles by year, and whether "Epilepsy, Tonic-Clonic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 1 | 2 |
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2007 | 2 | 1 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Epilepsy, Tonic-Clonic" by people in Profiles.
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Long-term treatment with ganaxolone for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: Two-year open-label extension follow-up. Epilepsia. 2024 Jan; 65(1):37-45.
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Cortico-striato-thalamo-cerebellar networks of structural covariance underlying different epilepsy syndromes associated with generalized tonic-clonic seizures. Hum Brain Mapp. 2021 03; 42(4):1102-1115.
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Automated detection of sudden unexpected death in epilepsy risk factors in electronic medical records using natural language processing. Epilepsia. 2019 06; 60(6):1209-1220.
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Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017 06; 58(6):1005-1014.
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Drug-Related Hyponatremic Encephalopathy: Rapid Clinical Response Averts Life-Threatening Acute Cerebral Edema. Am J Case Rep. 2016 Mar 09; 17:150-3.
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Long-term Patient Outcomes After Microsurgical Treatment of Blister-Like Aneurysms of the Basilar Artery. Neurosurgery. 2015 Sep; 11 Suppl 3:387-93.
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Side-to-side axial movements. Adding a new sign to the asymmetry of the clonic phase and asymmetric seizure termination in differentiating primary and secondarily generalised tonic-clonic seizures. Epileptic Disord. 2014 Mar; 16(1):1-4.
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Development of new treatment approaches for epilepsy: unmet needs and opportunities. Epilepsia. 2013 Aug; 54 Suppl 4:3-12.
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Flexible laryngoscopy in post-seizure lingual hematoma. Clin Neurol Neurosurg. 2013 Aug; 115(8):1530-1.
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Duchenne muscular dystrophy and epilepsy. Neuromuscul Disord. 2013 Apr; 23(4):313-5.