Helix-Loop-Helix Motifs

"Helix-Loop-Helix Motifs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

Descriptor ID

D018257

MeSH Number(s)

G02.111.570.790.709.600.040.360

Concept/Terms

Helix-Loop-Helix Motifs

Below are MeSH descriptors whose meaning is more general than "Helix-Loop-Helix Motifs".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Molecular Conformation [G02.111.570.790]
Protein Conformation [G02.111.570.790.709]
Protein Structure, Secondary [G02.111.570.790.709.600]
Amino Acid Motifs [G02.111.570.790.709.600.040]
Helix-Loop-Helix Motifs [G02.111.570.790.709.600.040.360]

Below are MeSH descriptors whose meaning is related to "Helix-Loop-Helix Motifs".

Below are MeSH descriptors whose meaning is more specific than "Helix-Loop-Helix Motifs".

Helix-Loop-Helix Motifs
EF Hand Motifs
Helix-Turn-Helix Motifs

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Helix-Loop-Helix Motifs" by people in Harvard Catalyst Profiles by year, and whether "Helix-Loop-Helix Motifs" was a major or minor topic of these publication.

Bar chart showing 75 publications over 16 distinct years, with a maximum of 11 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	2	4
1995	3	5	8
1996	4	7	11
1997	3	2	5
1998	3	7	10
1999	2	4	6
2000	5	4	9
2001	3	4	7
2002	1	1	2
2003	1	2	3
2004	2	1	3
2009	0	1	1
2010	0	1	1
2012	0	3	3
2017	0	1	1
2023	0	1	1

Below are the most recent publications written about "Helix-Loop-Helix Motifs" by people in Profiles.

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs. PLoS One. 2023; 18(9):e0292080.

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The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor. J Biol Chem. 2017 08 04; 292(31):12885-12894.

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Genomic occupancy of HLH, AP1 and Runx2 motifs within a nuclease sensitive site of the Runx2 gene. J Cell Physiol. 2013 Feb; 228(2):313-21.

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GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex. J Neurosci. 2012 Jun 06; 32(23):7791-805.

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Dependence of corneal stem/progenitor cells on ocular surface innervation. Invest Ophthalmol Vis Sci. 2012 Feb 21; 53(2):867-72.

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Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors. Pac Symp Biocomput. 2012; 104-15.

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Identification of specific DNA binding residues in the TCP family of transcription factors in Arabidopsis. Plant Cell. 2010 Apr; 22(4):1174-89.

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Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors. J Cell Biochem. 2010 Feb 01; 109(2):417-24.

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Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia. 2009 Aug; 52(8):1589-98.

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Specificity of Atonal and Scute bHLH factors: analysis of cognate E box binding sites and the influence of Senseless. Genes Cells. 2008 Sep; 13(9):915-29.

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