WT1 Proteins

"WT1 Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.

Descriptor ID

D025721

MeSH Number(s)

D12.776.624.776.960

Concept/Terms

WT1 Proteins

Below are MeSH descriptors whose meaning is more general than "WT1 Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
WT1 Proteins [D12.776.624.776.960]

Below are MeSH descriptors whose meaning is related to "WT1 Proteins".

Below are MeSH descriptors whose meaning is more specific than "WT1 Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "WT1 Proteins" by people in Harvard Catalyst Profiles by year, and whether "WT1 Proteins" was a major or minor topic of these publication.

Bar chart showing 120 publications over 28 distinct years, with a maximum of 8 publications in 2002 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	7	7
1996	0	4	4
1997	0	4	4
1998	0	5	5
1999	0	6	6
2000	0	2	2
2001	2	5	7
2002	7	1	8
2003	2	0	2
2004	5	1	6
2005	2	1	3
2007	3	3	6
2008	2	2	4
2009	1	2	3
2010	5	0	5
2011	4	4	8
2012	1	1	2
2013	2	5	7
2014	3	3	6
2015	4	2	6
2016	1	2	3
2017	2	1	3
2018	2	2	4
2020	0	3	3
2021	1	1	2
2022	0	2	2
2024	0	1	1

Below are the most recent publications written about "WT1 Proteins" by people in Profiles.

Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP. PLoS Pathog. 2024 Jan; 20(1):e1011881.

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Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors-A Report of two Cases. Int J Surg Pathol. 2023 Aug; 31(5):866-871.

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Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling. Dis Model Mech. 2022 01 01; 15(1).

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Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice. Sci Rep. 2021 08 05; 11(1):15940.

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Mesothelial cells are not a source of adipocytes in mice. Cell Rep. 2021 07 13; 36(2):109388.

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EWSR1-WT1 gene fusions in neoplasms other than desmoplastic small round cell tumor: a report of three unusual tumors involving the female genital tract and review of the literature. Mod Pathol. 2021 10; 34(10):1912-1920.

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Therapeutic Potential of NTRK3 Inhibition in Desmoplastic Small Round Cell Tumor. Clin Cancer Res. 2021 02 15; 27(4):1184-1194.

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Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury. Sci Adv. 2020 07; 6(30):eabb5460.

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Comprehensive genetic diagnosis of Japanese patients with severe proteinuria. Sci Rep. 2020 01 14; 10(1):270.

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Expression of tumor-associated antigens in breast cancer subtypes. Breast. 2020 Feb; 49:202-209.

View in: PubMed

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