Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Brendan D. Manning, Ph.D.

Concepts (429)

Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
TOR Serine-Threonine Kinases52201821096.090 Why?
Multiprotein Complexes33201711195.230 Why?
Proto-Oncogene Proteins c-akt22202125032.980 Why?
Tumor Suppressor Proteins31202228492.760 Why?
Tuberous Sclerosis15202210292.170 Why?
Signal Transduction502021234032.140 Why?
Activating Transcription Factor 442021801.820 Why?
Lysosomes520228931.480 Why?
Phosphatidylinositol 3-Kinases13201929381.390 Why?
Protein Kinases14200916401.350 Why?
Sterol Regulatory Element Binding Proteins32017271.240 Why?
Sterol Regulatory Element Binding Protein 1420151371.100 Why?
Protein Biosynthesis7201721261.090 Why?
Proteins17201661031.090 Why?
Metabolism220191960.950 Why?
Ribosomal Protein S6 Kinases720132050.880 Why?
Purine Nucleotides22022280.840 Why?
IMP Dehydrogenase12020340.740 Why?
Ribonucleosides12020820.720 Why?
Transcription Factors152014122080.710 Why?
Sirolimus10201715640.690 Why?
Serine220228260.670 Why?
Glutathione220215890.660 Why?
Nuclear Respiratory Factor 122015230.660 Why?
AMP-Activated Protein Kinases620176110.650 Why?
Neoplasms172019216830.640 Why?
Energy Metabolism5201928990.640 Why?
NADP120192260.630 Why?
Amino Acids6202217360.620 Why?
Mycophenolic Acid120203430.620 Why?
Animals6820221687570.620 Why?
Drug Resistance, Fungal12017520.610 Why?
Intracellular Signaling Peptides and Proteins3202229150.610 Why?
Sterol Regulatory Element Binding Protein 222015520.610 Why?
Proto-Oncogene Proteins6201745540.600 Why?
Insulin10202165800.600 Why?
Nucleotides220174640.590 Why?
Liver6202174740.570 Why?
Phosphotransferases (Alcohol Group Acceptor)120194370.570 Why?
Phosphorylation17201984360.560 Why?
Metabolic Networks and Pathways420197830.550 Why?
Fatty Acids2202218090.550 Why?
Mice452022811830.550 Why?
Lipogenesis220152120.540 Why?
Glycolysis420218270.540 Why?
Tetrahydrofolates12016610.530 Why?
Genes, Tumor Suppressor7201710970.530 Why?
Oncogene Proteins120197490.520 Why?
GTPase-Activating Proteins520224980.520 Why?
Glucose6202143970.500 Why?
Lipid Metabolism3201518890.490 Why?
HeLa Cells7201731280.480 Why?
Lipids3201633050.470 Why?
Giant Cells120141870.470 Why?
Mice, Knockout152022145570.470 Why?
Elongation Factor 2 Kinase12013100.470 Why?
Purines220225940.470 Why?
Cell Division5200945680.460 Why?
Peptide Chain Elongation, Translational12013330.460 Why?
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)12013110.450 Why?
Dihydroorotase12013110.450 Why?
Aspartate Carbamoyltransferase12013220.450 Why?
Repressor Proteins8200530230.450 Why?
Monomeric GTP-Binding Proteins520121990.450 Why?
Ribosomal Protein S6 Kinases, 90-kDa22010560.440 Why?
Ribosomal Protein S6 Kinases, 70-kDa320171040.440 Why?
Models, Biological10201295830.420 Why?
Carrier Proteins6201250210.420 Why?
Metformin220178350.410 Why?
Enzyme Inhibitors2202037980.410 Why?
Proteasome Endopeptidase Complex2201513380.410 Why?
Microtubule Proteins32000610.400 Why?
Hepatocytes3201712110.400 Why?
Saccharomyces cerevisiae5201727520.400 Why?
Isocitrate Dehydrogenase120168710.380 Why?
Cell Line, Tumor142021166890.370 Why?
Pentose Phosphate Pathway120101240.360 Why?
Immunoblotting5201716820.360 Why?
Feedback, Physiological320114790.350 Why?
Monoacylglycerol Lipases12010480.350 Why?
Cell Proliferation122021104810.340 Why?
RNA Interference7201828890.340 Why?
Proto-Oncogene Proteins p21(ras)3201516920.340 Why?
Nutritional Physiological Phenomena120113700.330 Why?
Neuropeptides520129420.330 Why?
Adipocytes3201211840.320 Why?
Tacrolimus Binding Proteins120091950.320 Why?
Cell Line112021159970.320 Why?
Caenorhabditis elegans2201614190.320 Why?
Glioblastoma2202134810.310 Why?
Neoplasm Proteins1202037030.300 Why?
Cell Growth Processes120083990.300 Why?
Analgesics1201310400.280 Why?
Humans7220217443430.280 Why?
Fibroblasts7202141610.280 Why?
Mice, Inbred C57BL122021218270.270 Why?
Mitochondria3201635200.270 Why?
Transcription, Genetic4201677220.270 Why?
Myocardium1201947760.270 Why?
Homeostasis4201633400.260 Why?
Heart1201944670.260 Why?
Glycogen Synthase Kinase 3120064300.250 Why?
Chromatography, Liquid320199760.240 Why?
HEK293 Cells4201942040.230 Why?
Drug Delivery Systems2201722190.220 Why?
Saccharomyces cerevisiae Proteins4200018880.220 Why?
Neurons2202293380.220 Why?
3T3-L1 Cells320131980.210 Why?
Gene Expression Regulation42019120720.210 Why?
Phosphotransferases120023080.200 Why?
Gene Expression Regulation, Enzymologic1200612130.200 Why?
Feedback120057950.200 Why?
Animal Feed120211100.200 Why?
Fungal Proteins320009120.190 Why?
Hypoxia-Inducible Factor 1, alpha Subunit320186270.190 Why?
Pyrimidines1201329420.190 Why?
Microtubule-Associated Proteins3200010860.190 Why?
Gene Expression Regulation, Neoplastic4201984280.190 Why?
Citric Acid Cycle120212320.180 Why?
Antibiotics, Antineoplastic420156920.180 Why?
Molecular Motor Proteins120001070.180 Why?
Genetic Techniques120024350.180 Why?
Carcinoma, Hepatocellular1201222140.170 Why?
Gene Knockdown Techniques3201516550.170 Why?
Drug Resistance, Neoplasm2201351720.170 Why?
Mice, Transgenic5202197340.170 Why?
HCT116 Cells220174080.170 Why?
Phospholipids120227840.170 Why?
Nitrogen Isotopes12019840.170 Why?
Adaptor Proteins, Signal Transducing5201329160.160 Why?
Amino Acids, Sulfur12018160.160 Why?
Amino Acid Sequence62012138150.160 Why?
Phosphoribosylglycinamide Formyltransferase1201730.160 Why?
Food220137710.160 Why?
Carbon Isotopes120194670.160 Why?
Adenosylmethionine Decarboxylase12017110.160 Why?
Thymidylate Synthase12017750.150 Why?
Genes, Lethal120172420.150 Why?
Isotope Labeling120194060.150 Why?
Cells, Cultured92019192290.150 Why?
Cell Cycle4201729670.150 Why?
Hydrogen Sulfide120181370.140 Why?
Polyamines120171200.140 Why?
Insulin-Like Growth Factor I2201920150.140 Why?
RNA, Ribosomal120172460.140 Why?
Methenyltetrahydrofolate Cyclohydrolase1201690.140 Why?
Methylenetetrahydrofolate Dehydrogenase (NADP)12016170.140 Why?
Oxidoreductases Acting on CH-CH Group Donors120171670.140 Why?
ATP Citrate (pro-S)-Lyase12016260.140 Why?
Tumor Cells, Cultured5201763140.140 Why?
Fasting1202215930.140 Why?
Liver Neoplasms1201242530.140 Why?
Substrate Specificity3200718010.140 Why?
Tandem Mass Spectrometry2201911570.140 Why?
rho GTP-Binding Proteins119972930.130 Why?
Molecular Sequence Data62012181110.130 Why?
Glutamine120195780.130 Why?
Cytosol120199010.130 Why?
Pressure1201912030.130 Why?
Autophagy2201413000.130 Why?
Lysophosphatidylcholines12015810.130 Why?
Brain12022263850.130 Why?
Epistasis, Genetic120173650.130 Why?
Class III Phosphatidylinositol 3-Kinases12014180.130 Why?
Drug Screening Assays, Antitumor120177300.130 Why?
Eukaryotic Initiation Factor-2120161900.130 Why?
Embryo, Mammalian1202117010.130 Why?
Triglycerides1202224540.130 Why?
Glutarates120162360.120 Why?
Nuclear Proteins1200958530.120 Why?
Nuclear Receptor Coactivators12014590.120 Why?
Cytoskeletal Proteins1200013640.120 Why?
RNA, Small Interfering5201835050.120 Why?
Caloric Restriction120163020.120 Why?
PTEN Phosphohydrolase4201711420.120 Why?
Oxidation-Reduction1201921870.120 Why?
Drug Therapy120174970.120 Why?
Nucleoside-Phosphate Kinase12013230.120 Why?
Cell Polarity220136450.120 Why?
GTP-Binding Proteins119979700.110 Why?
Lymphangioleiomyomatosis120152100.110 Why?
Mice, Inbred NOD1201718780.110 Why?
Hamartoma220052380.110 Why?
Macrophage Activation120165580.110 Why?
Thiolester Hydrolases12013860.110 Why?
Fluorouracil1201716190.110 Why?
Phospholipid Transfer Proteins12013910.110 Why?
Disease Susceptibility1201917820.110 Why?
Biosynthetic Pathways120131370.110 Why?
Cytoskeleton1199711850.110 Why?
Isoenzymes1201717260.100 Why?
Mice, SCID1201727160.100 Why?
RNA Splicing120169070.100 Why?
Phosphoric Monoester Hydrolases220054310.100 Why?
Organ Specificity1201720080.100 Why?
Ferritins120145900.100 Why?
Intercellular Signaling Peptides and Proteins2200916760.100 Why?
Proliferating Cell Nuclear Antigen120122850.100 Why?
Benzoquinones120112010.100 Why?
Methotrexate1201717270.100 Why?
Binding Sites3200961140.090 Why?
GTP Phosphohydrolases120145090.090 Why?
PPAR gamma220134930.090 Why?
Drosophila1201714910.090 Why?
Caenorhabditis elegans Proteins120168520.090 Why?
Molecular Targeted Therapy3201727270.090 Why?
Nerve Sheath Neoplasms120111900.090 Why?
Phosphothreonine12009630.090 Why?
Drosophila Proteins2201717030.090 Why?
Seizures1202228590.090 Why?
Lactams, Macrocyclic120113200.090 Why?
Light1201613740.090 Why?
Macrophages2201656550.090 Why?
Metabolomics3201714840.090 Why?
Phosphoserine120092060.090 Why?
Protein Kinase C-alpha120091120.080 Why?
Adipogenesis120123590.080 Why?
Cell Line, Transformed120108980.080 Why?
Longevity1201610700.080 Why?
Feeding Behavior1202131880.080 Why?
Immunohistochemistry32012113660.080 Why?
14-3-3 Proteins120092140.080 Why?
Vertebrates120092270.080 Why?
Insulin Resistance4201438640.080 Why?
Neurofibromin 2120092670.080 Why?
Lymph Nodes1201934740.080 Why?
Cell Survival4201958820.080 Why?
Angiomyolipoma120091900.080 Why?
Phosphoprotein Phosphatases120093370.080 Why?
Reperfusion Injury1201410260.080 Why?
Cell Enlargement12007610.080 Why?
Boronic Acids120129650.080 Why?
Mutation52017297860.070 Why?
5' Untranslated Regions120082490.070 Why?
Vascular Endothelial Growth Factor A1201835080.070 Why?
Cell Cycle Proteins3201534620.070 Why?
Mass Spectrometry2201522030.070 Why?
Protein Binding3201493860.070 Why?
Immediate-Early Proteins120094530.070 Why?
Models, Animal2201121710.070 Why?
Iron1201417740.070 Why?
ras Proteins1201110600.070 Why?
Neovascularization, Physiologic2201813510.070 Why?
CD8-Positive T-Lymphocytes1201944790.070 Why?
Conserved Sequence1200912020.070 Why?
Pyrazines1201212300.070 Why?
Muscles1201116140.070 Why?
Esophageal Diseases120061660.070 Why?
Cell Membrane1201537480.060 Why?
Hypothalamus1201110630.060 Why?
Multienzyme Complexes220086860.060 Why?
Amino Acid Substitution1200917910.060 Why?
Herpesvirus 8, Human120062580.060 Why?
Dose-Response Relationship, Drug12017109430.060 Why?
3T3 Cells2200411010.060 Why?
Pancreas1201116860.060 Why?
Enzyme Activation2201737010.060 Why?
Blotting, Western2200951790.060 Why?
Carcinoma, Non-Small-Cell Lung2201352210.060 Why?
Sequence Alignment1200822560.060 Why?
RNA, Messenger22009130330.060 Why?
Cell Size120056430.060 Why?
Protein Footprinting12002100.060 Why?
Receptors, Chemokine120066690.060 Why?
DNA Footprinting12002980.060 Why?
Energy Intake1201121480.050 Why?
Molecular Weight2200222550.050 Why?
NF-kappa B1201124990.050 Why?
Cell Movement2202252170.050 Why?
Male920183501180.050 Why?
Two-Hybrid System Techniques120024640.050 Why?
MicroRNAs1201737520.050 Why?
Pheromones22000980.050 Why?
Multiple Myeloma1201951810.050 Why?
Interleukin-42201611470.050 Why?
Polymerase Chain Reaction2201161710.050 Why?
Biomedical Research1201633090.050 Why?
Leptin1200815990.050 Why?
T-Lymphocytes12017101800.040 Why?
Carbon Cycle12019180.040 Why?
eIF-2 Kinase220111490.040 Why?
Viral Proteins1200619000.040 Why?
Adipose Tissue1201132790.040 Why?
DNA-Binding Proteins2201496480.040 Why?
Cystathionine gamma-Lyase12018360.040 Why?
Carbon120226870.040 Why?
Genomics2201357200.040 Why?
Gastrointestinal Tract120048140.040 Why?
Metabolic Diseases120046580.040 Why?
Genes, Fungal119994550.040 Why?
Ischemia2201819070.040 Why?
K562 Cells120196340.040 Why?
Burkholderia cepacia11996220.040 Why?
Genes, Essential120171830.040 Why?
Kidney Neoplasms2201242620.030 Why?
Cell Transformation, Neoplastic1200629420.030 Why?
S-Adenosylmethionine120172120.030 Why?
Cytotoxicity, Immunologic1201913690.030 Why?
RNA Precursors120162080.030 Why?
Protein Stability120175570.030 Why?
Phospholipases A2120152030.030 Why?
Disease Progression12012132840.030 Why?
Chromatin Assembly and Disassembly120196350.030 Why?
Chromatography, High Pressure Liquid1201915720.030 Why?
Naphthyridines120151180.030 Why?
Amino Acids, Essential12014240.030 Why?
Sequence Homology, Amino Acid1199928390.030 Why?
DNA Primers1199928920.030 Why?
Physical Conditioning, Animal120183620.030 Why?
Gene Deletion1200227510.030 Why?
Prostatic Neoplasms12017111240.030 Why?
Diet, Protein-Restricted12014710.030 Why?
Membrane Proteins1201178800.030 Why?
Sensitivity and Specificity12009147220.030 Why?
Protein-Tyrosine Kinases1200324550.030 Why?
Endoplasmic Reticulum2201111440.030 Why?
Thymine Nucleotides12013630.030 Why?
Mice, 129 Strain120143860.030 Why?
Endothelial Cells1200634790.030 Why?
Phagosomes120141930.030 Why?
Chitin12013410.030 Why?
Acetylation1201610850.030 Why?
Immunologic Memory1201913480.030 Why?
STAT6 Transcription Factor120131990.030 Why?
Inhibitory Concentration 50120134590.030 Why?
Disease Models, Animal32018180290.030 Why?
Dose-Response Relationship, Radiation120148760.030 Why?
Oxidative Phosphorylation120144810.030 Why?
Apoptosis1200897270.030 Why?
Genome, Bacterial119967600.030 Why?
Microtubules1199710900.020 Why?
Chemokines120169700.020 Why?
Gene Knockout Techniques120148090.020 Why?
Antineoplastic Agents22011136950.020 Why?
Antineoplastic Combined Chemotherapy Protocols12011115240.020 Why?
Nitric Oxide1201921320.020 Why?
Goals120167060.020 Why?
Kidney Diseases, Cystic120121860.020 Why?
In Situ Nick-End Labeling120116430.020 Why?
Brain Neoplasms1201188630.020 Why?
Interleukin-61201932000.020 Why?
Arachnoid12009480.020 Why?
Gene Regulatory Networks1201717080.020 Why?
Lung Neoplasms12013131020.020 Why?
Oxidative Stress2201130860.020 Why?
HSP90 Heat-Shock Proteins120114340.020 Why?
Lymphocyte Activation1201955240.020 Why?
Transfection2200958920.020 Why?
Genome1201618080.020 Why?
Obesity12010127450.020 Why?
Phenylbutyrates12008690.020 Why?
Tumor Suppressor Protein p532201129480.020 Why?
Protein Processing, Post-Translational1201619900.020 Why?
Cell Death1201317060.020 Why?
Base Sequence11999127970.020 Why?
High-Throughput Screening Assays120139440.020 Why?
Adaptation, Physiological1201413120.020 Why?
Fluorescent Antibody Technique1201125050.020 Why?
Stress, Physiological1201414030.020 Why?
Peptides1199944090.020 Why?
Oncogene Protein v-akt120061350.020 Why?
Epigenesis, Genetic1201936470.020 Why?
DNA Replication1201313990.020 Why?
Drosophila melanogaster1201517080.020 Why?
Rupture, Spontaneous120063540.020 Why?
Insulin Receptor Substrate Proteins120085630.020 Why?
Histones1201625990.020 Why?
Cisplatin1201116620.020 Why?
Lipopolysaccharides1201322160.020 Why?
Paracrine Communication120062770.020 Why?
Mice, Inbred BALB C1201463860.020 Why?
Peutz-Jeghers Syndrome12004500.020 Why?
Female520183801940.020 Why?
Phosphoproteins2200324400.010 Why?
Reactive Oxygen Species1201120770.010 Why?
Inflammation Mediators1201318890.010 Why?
Neurilemmoma120095470.010 Why?
Sarcoma, Kaposi120063700.010 Why?
DNA Damage1201324320.010 Why?
Promoter Regions, Genetic1201458670.010 Why?
Models, Genetic1201334940.010 Why?
Precipitin Tests120038290.010 Why?
Cell Differentiation12019114830.010 Why?
Phenotype11999163650.010 Why?
Body Weight1201246690.010 Why?
Electrophoresis, Polyacrylamide Gel1200318010.010 Why?
Chemical Fractionation12000650.010 Why?
B-Lymphocytes1201446650.010 Why?
Centrifugation, Density Gradient120003130.010 Why?
Meningioma1200912090.010 Why?
Syndrome1200632510.010 Why?
Biological Assay120036520.010 Why?
Mutagenesis, Site-Directed1200317230.010 Why?
Sucrose120001640.010 Why?
Mice, Nude1200636890.010 Why?
Protein Interaction Mapping120036270.010 Why?
Sequence Analysis120002560.010 Why?
Colonic Polyps120045420.010 Why?
Rats12015242600.010 Why?
Dimerization120008930.010 Why?
Flow Cytometry1200959740.010 Why?
Magnetic Resonance Imaging12005354210.010 Why?
Neoplasms, Experimental1200312760.010 Why?
Plasmids1200323070.010 Why?
Adenosine Triphosphate1200420250.010 Why?
Aging1201686640.010 Why?
Replicon11996340.010 Why?
Down-Regulation1200430020.010 Why?
Point Mutation1200216230.010 Why?
Pseudomonas119961170.010 Why?
Biodegradation, Environmental119962190.010 Why?
DNA, Ribosomal119962900.010 Why?
Chromosomes, Bacterial119962820.010 Why?
RNA, Bacterial119963900.010 Why?
Protein Structure, Tertiary1200038460.010 Why?
RNA, Ribosomal, 16S119969540.010 Why?
DNA Transposable Elements119967480.010 Why?
Genes, Bacterial1199610790.010 Why?
DNA, Bacterial1199614650.010 Why?
Phylogeny1199628030.010 Why?
Chromosome Mapping1199647400.000 Why?
United States12016698720.000 Why?
Child, Preschool12008410060.000 Why?
Treatment Outcome12012631140.000 Why?
Aged, 80 and over12006577760.000 Why?
Retrospective Studies12006774490.000 Why?
Aged120061632800.000 Why?
Middle Aged120062133830.000 Why?
Adult120062140550.000 Why?
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Concepts (429)
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.