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Bruce A. Yankner, M.D.,Ph.D.

Concepts (407)

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Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Amyloid beta-Peptides36202333881.700 Why?
Alzheimer Disease31202375611.530 Why?
Aging20202385301.270 Why?
Repressor Proteins6202130421.200 Why?
Amyloid beta-Protein Precursor13201611051.140 Why?
Neurons31202293441.130 Why?
Hypothalamus2201710700.720 Why?
Caenorhabditis elegans Proteins320228620.650 Why?
Longevity3202210790.610 Why?
Amyloid820067540.590 Why?
Presenilins12016530.560 Why?
Brain222021257640.530 Why?
Neural Stem Cells220198510.480 Why?
I-kappa B Kinase220182560.460 Why?
Amnesia120152440.450 Why?
Membrane Proteins14200679210.430 Why?
Stress, Physiological3202114210.430 Why?
Oxidative Stress8201431030.430 Why?
Hippocampus10201536040.420 Why?
Apoptosis11202197560.420 Why?
Neurotoxins320022400.410 Why?
Nervous System320025600.410 Why?
Induced Pluripotent Stem Cells2201916380.400 Why?
Neurodegenerative Diseases3201610130.400 Why?
Presenilin-11220086290.380 Why?
Nerve Degeneration820027660.380 Why?
Gene Regulatory Networks1201917190.370 Why?
tau Proteins5202317500.370 Why?
Endopeptidases220057730.350 Why?
NF-kappa B3201725490.350 Why?
Peptide Fragments11201850370.300 Why?
Transcription Factors42019120800.300 Why?
Animals5720231687140.300 Why?
Cells, Cultured242018194850.300 Why?
Nerve Tissue Proteins6201345010.290 Why?
Gonadotropin-Releasing Hormone1201312000.290 Why?
Nerve Growth Factors720005800.290 Why?
Presenilin-2620081040.290 Why?
Astrocytes4201812430.290 Why?
DNA-Binding Proteins3201997160.260 Why?
Cerebral Cortex12200856980.260 Why?
Autophagy4201513060.250 Why?
Neuroprotective Agents320149450.250 Why?
Signal Transduction92017234480.240 Why?
Mice, Transgenic5202397890.240 Why?
Histone Acetyltransferases120053430.230 Why?
Trans-Activators3200529810.230 Why?
Neurofibrillary Tangles420004230.230 Why?
Synapses4200817210.220 Why?
Gene Expression Regulation112021121800.220 Why?
Transfection9200559650.210 Why?
MicroRNAs2201737150.210 Why?
Mice252023803000.210 Why?
Receptors, Cell Surface5200028770.210 Why?
Down Syndrome320028380.210 Why?
Amyloid Precursor Protein Secretases420165810.200 Why?
DNA Damage3201524660.200 Why?
Nuclear Proteins4200859130.200 Why?
Protein Processing, Post-Translational4200020070.200 Why?
Active Transport, Cell Nucleus120024330.190 Why?
Oncogene Proteins120057560.190 Why?
Plaque, Amyloid320007020.190 Why?
Parkinson Disease2200527520.180 Why?
Evolution, Molecular1200819410.180 Why?
Caspases220009410.170 Why?
Nuclear Lamina12019480.170 Why?
Peptide Hydrolases120026260.170 Why?
Rats172008244140.170 Why?
Disease Progression22015131570.170 Why?
Oligonucleotides220215740.170 Why?
Mice, 129 Strain120193900.170 Why?
Humans6220237251870.170 Why?
Congo Red21996460.170 Why?
Cell Membrane3200538130.160 Why?
Receptor-Interacting Protein Serine-Threonine Kinases120181360.160 Why?
Protein Precursors3199111480.160 Why?
Gene Expression Profiling3202193790.160 Why?
Cognition Disorders2201040110.150 Why?
Podocytes120213920.150 Why?
Mice, Knockout72019147690.140 Why?
Cell Line132021162630.140 Why?
Cytoskeletal Proteins2199913830.140 Why?
Mutation82008296720.140 Why?
Forkhead Transcription Factors2202216140.140 Why?
Axons3201816880.140 Why?
Calcium2200657580.140 Why?
Spastic Paraplegia, Hereditary119981540.140 Why?
Apolipoproteins E2201914330.140 Why?
Neurofibrils11995770.130 Why?
Pheochromocytoma619913400.130 Why?
Tumor Cells, Cultured6200263710.130 Why?
RNA-Binding Proteins2201919070.130 Why?
GATA4 Transcription Factor120151340.130 Why?
In Situ Hybridization, Fluorescence1202126500.130 Why?
Dopamine1200216070.130 Why?
Cyclin-Dependent Kinases220106680.120 Why?
Apolipoprotein E4120186330.120 Why?
Caenorhabditis elegans2202214260.120 Why?
Adaptation, Physiological1202113290.120 Why?
Synucleins220051110.120 Why?
Single-Cell Analysis2202221500.120 Why?
Mitochondria2201035860.120 Why?
Cell Differentiation82019115070.120 Why?
Qc-SNARE Proteins12013230.120 Why?
Langerhans Cells119941730.120 Why?
RNA, Messenger22008130440.120 Why?
Autistic Disorder1202211250.110 Why?
Exosomes120173950.110 Why?
CA3 Region, Hippocampal12013540.110 Why?
Ubiquitin-Activating Enzymes12013760.110 Why?
Species Specificity3200825150.110 Why?
Cell Death2201417050.110 Why?
Phagosomes120142010.110 Why?
Neuroglia120189220.110 Why?
RNA Interference2201929560.110 Why?
RNA2202127180.110 Why?
Transcription, Genetic3200878140.110 Why?
Neurogenesis120198200.110 Why?
Fibroblasts3201941980.110 Why?
Cell Nucleus4201430070.110 Why?
Lewy Body Disease120142150.110 Why?
DNA Repair3201320470.100 Why?
Phosphorylation7201884870.100 Why?
Ubiquitination220139980.100 Why?
Frontotemporal Dementia120142240.100 Why?
Aspartic Acid Endopeptidases220053100.100 Why?
Antioxidants3200816740.100 Why?
Islet Amyloid Polypeptide31996410.100 Why?
Histone Demethylases120133160.100 Why?
Chromatin Immunoprecipitation120149000.100 Why?
Suppressor of Cytokine Signaling Proteins120111790.100 Why?
Solubility3200011020.100 Why?
Tachykinins11990770.100 Why?
Protein Transport1201620150.090 Why?
Substance P119913350.090 Why?
Reactive Oxygen Species2201020790.090 Why?
Mice, Inbred C57BL62019221340.090 Why?
Cell Survival4202159140.090 Why?
Synaptic Transmission3201811830.090 Why?
Aged, 80 and over72021576560.090 Why?
Protein Structure, Tertiary3201339020.090 Why?
Inflammation22015103350.080 Why?
Phosphoproteins3201824770.080 Why?
Protein Kinase C1199312390.080 Why?
HeLa Cells4201331650.080 Why?
Peroxiredoxins12008500.080 Why?
PC12 Cells320003340.080 Why?
Cell Adhesion2199231790.080 Why?
alpha-Synuclein220056860.080 Why?
Amino Acids1199317240.080 Why?
Ubiquitin-Protein Ligases2201318460.080 Why?
Dendrites119905080.070 Why?
Thioredoxins120082120.070 Why?
Receptor, Notch1220005130.070 Why?
Disease Models, Animal22023180330.070 Why?
Subcellular Fractions220055570.070 Why?
Proteins4200860880.070 Why?
Down-Regulation1201430240.070 Why?
Fetus3200218480.070 Why?
Cerebral Arterial Diseases11986820.070 Why?
Transcriptional Activation2200518210.070 Why?
Nerve Regeneration120118030.070 Why?
Epitopes2199725600.070 Why?
PTEN Phosphohydrolase1201111480.070 Why?
Octamer Transcription Factors12005230.070 Why?
Gene Expression Regulation, Developmental1199736920.070 Why?
Sirtuins120083700.070 Why?
Nuclear Matrix-Associated Proteins12005430.070 Why?
Amygdala1201312940.070 Why?
Aged820211614860.070 Why?
Heparin1199216190.060 Why?
Up-Regulation1201442340.060 Why?
Golgi Apparatus219984230.060 Why?
Genomic Instability120087060.060 Why?
Granuloma119863200.060 Why?
Copper120063690.060 Why?
Cats2199610040.060 Why?
Phosphatidylinositol 3-Kinases2201029120.060 Why?
Histones1201325590.060 Why?
Antibodies1199124170.060 Why?
Neurites219973810.060 Why?
Biological Transport3199921170.060 Why?
Endoplasmic Reticulum2200011760.060 Why?
Carbonyl Cyanide m-Chlorophenyl Hydrazone12002250.060 Why?
Receptors, N-Methyl-D-Aspartate120088920.060 Why?
Uncoupling Agents12002470.050 Why?
Vasculitis119865130.050 Why?
Genes, Recessive120056490.050 Why?
Purines120055830.050 Why?
Blotting, Western2200852360.050 Why?
Gene Deletion2200027980.050 Why?
Zinc120066820.050 Why?
Insulin-Like Growth Factor I1201020210.050 Why?
Nervous System Diseases1199216200.050 Why?
Carbocyanines120021910.050 Why?
Homeostasis2202133300.050 Why?
14-3-3 Proteins120022220.050 Why?
Tyrosine 3-Monooxygenase120023760.050 Why?
Phylogeny1200827880.050 Why?
Fluorescent Antibody Technique1200525690.050 Why?
RNA, Small Interfering2201335290.050 Why?
Sclerosis120212100.050 Why?
In Situ Nick-End Labeling120026460.050 Why?
Genes, Reporter1200515710.050 Why?
Apoptosis Regulatory Proteins1200611380.050 Why?
Chromosomes, Human, Pair 16120223570.050 Why?
Recombinant Proteins4200266690.050 Why?
Calcium-Calmodulin-Dependent Protein Kinases219995010.050 Why?
Receptors, Notch120057510.050 Why?
Substantia Nigra120023570.050 Why?
Microglia2201812130.050 Why?
Glycogen Synthase Kinase 3219994320.050 Why?
Intracellular Signaling Peptides and Proteins2201329430.050 Why?
Biopolymers120001930.040 Why?
Chromosome Disorders120225130.040 Why?
Microscopy, Confocal1200519880.040 Why?
Receptors, Drug119791610.040 Why?
HIV1198615630.040 Why?
Islets of Langerhans2199613330.040 Why?
Microscopy, Fluorescence2199827850.040 Why?
Promoter Regions, Genetic2201559340.040 Why?
Molecular Sequence Data52008183010.040 Why?
Callithrix11998950.040 Why?
Protease Inhibitors219937990.040 Why?
Apolipoprotein E312018890.040 Why?
Adenomatous Polyposis Coli Protein119981890.040 Why?
Cytoskeleton2202112270.040 Why?
Superoxide Dismutase120006110.040 Why?
Diabetes Mellitus1199655220.040 Why?
Nuclear Envelope119791830.040 Why?
Chromosome Deletion1202213930.040 Why?
Staurosporine120182540.040 Why?
Albuminuria120216670.040 Why?
Chromatin1200828490.040 Why?
Receptors, Nerve Growth Factor319902000.040 Why?
DNA Breaks, Double-Stranded220136030.040 Why?
Benzimidazoles120028510.040 Why?
Epigenesis, Genetic1201035960.040 Why?
Cognition1201464250.040 Why?
Lysosomes220109060.040 Why?
beta Catenin2199910570.040 Why?
Amino Acid Sequence41993139320.040 Why?
Tissue Distribution2199723590.040 Why?
Adult820212116150.040 Why?
Xenopus Proteins119994430.040 Why?
Cell Line, Tumor32013166300.040 Why?
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins12015410.030 Why?
Fluoresceins119952340.030 Why?
Embryo, Nonmammalian119999050.030 Why?
Intracellular Fluid119952030.030 Why?
Cycloheximide119953500.030 Why?
Dactinomycin119953210.030 Why?
Neuronal Plasticity1200414020.030 Why?
Interleukin-1alpha12015840.030 Why?
Morphogenesis119997630.030 Why?
Oligonucleotide Array Sequence Analysis1200439650.030 Why?
Insulin1201065620.030 Why?
Xenopus laevis119999780.030 Why?
Phosphoserine119952100.030 Why?
Lipid Peroxidation119952950.030 Why?
Learning1200416490.030 Why?
Molecular Weight1199723270.030 Why?
Free Radical Scavengers119952230.030 Why?
GTP-Binding Proteins119999770.030 Why?
Body Patterning119996320.030 Why?
Rats, Sprague-Dawley2199783610.030 Why?
Enzyme Inhibitors1200538220.030 Why?
Receptors, Amino Acid11993300.030 Why?
Phorbol Esters119931100.030 Why?
Sequence Analysis, RNA1202220010.030 Why?
Models, Biological1201096690.030 Why?
Fluorescent Dyes1200219510.030 Why?
Diglycerides119931760.030 Why?
Sequence Deletion1199815470.030 Why?
Middle Aged420192122920.030 Why?
Hydrolysis119946930.030 Why?
SNARE Proteins120131000.030 Why?
Immunohistochemistry32003114840.030 Why?
Genes, Lethal120132470.030 Why?
Tetradecanoylphorbol Acetate119938310.030 Why?
Young Adult22021557810.030 Why?
Kinetics3199565540.030 Why?
Huntington Disease1199911120.030 Why?
S Phase120134320.030 Why?
Organoids120186890.030 Why?
Cyclin-Dependent Kinase Inhibitor p16120157210.030 Why?
Organ Specificity1199720220.030 Why?
Nerve Crush12011800.030 Why?
Enzyme Activation2200037390.030 Why?
Kidney2200570220.030 Why?
Energy Metabolism2201329340.030 Why?
Stem Cells1200535760.030 Why?
Exons1199824290.030 Why?
Membrane Glycoproteins1200337850.030 Why?
Macaca mulatta1199823880.030 Why?
Histocytochemistry119927330.030 Why?
Chromogranins119921610.030 Why?
Dendritic Spines120132330.030 Why?
Genome-Wide Association Study12010119680.030 Why?
Carcinogens119934670.030 Why?
Male620153470960.030 Why?
Protein Stability120135590.020 Why?
Radiation Tolerance120134860.020 Why?
Phenotype22021162720.020 Why?
Cell Growth Processes120113970.020 Why?
Locomotion120133760.020 Why?
Oxidation-Reduction1199621970.020 Why?
Optic Nerve Injuries120111510.020 Why?
Diabetes Mellitus, Type 211994114130.020 Why?
Dose-Response Relationship, Drug21994109710.020 Why?
Behavior, Animal1201818880.020 Why?
Vesicular Transport Proteins120133760.020 Why?
GAP-43 Protein119901540.020 Why?
Amyotrophic Lateral Sclerosis1200013890.020 Why?
Rats, Inbred Strains1199122270.020 Why?
Cerebellum1199714950.020 Why?
Spinal Cord1201818120.020 Why?
Adrenal Gland Neoplasms319917380.020 Why?
Models, Neurological1199817740.020 Why?
Lipid Metabolism1201819640.020 Why?
Temperature1199522080.020 Why?
Structure-Activity Relationship1199431370.020 Why?
Restriction Mapping119898960.020 Why?
Specific Pathogen-Free Organisms120082300.020 Why?
Microtubules1199512250.020 Why?
Oxidoreductases Acting on Sulfur Group Donors12008300.020 Why?
Fibroblast Growth Factor 2119906080.020 Why?
Optic Nerve120115540.020 Why?
Platelet-Derived Growth Factor119906370.020 Why?
Embryonic Development120137070.020 Why?
Peroxidases120081420.020 Why?
Yeasts120082860.020 Why?
Nucleic Acid Hybridization1198914170.020 Why?
Epidermal Growth Factor119907170.020 Why?
Protein Binding1200094690.020 Why?
Adenosine Triphosphate1199420360.020 Why?
Blotting, Northern1198915980.020 Why?
STAT3 Transcription Factor120118610.020 Why?
Microfilament Proteins1201311770.020 Why?
Cell Count1199118710.020 Why?
Cell Cycle1201529800.020 Why?
BRCA1 Protein1201311140.020 Why?
Sirtuin 1120082960.020 Why?
Tumor Necrosis Factor-alpha1201844090.020 Why?
Oxygen Consumption1201318950.020 Why?
Social Behavior1201311110.020 Why?
Drug Synergism1199018000.020 Why?
Thymus Neoplasms120082680.020 Why?
Retinal Ganglion Cells120117520.020 Why?
Brain Chemistry1199010020.020 Why?
Homosexuality119862640.020 Why?
Immunoblotting1198917280.020 Why?
Memory Disorders1201311500.020 Why?
Gene Knockout Techniques120088010.020 Why?
Analysis of Variance1199463980.020 Why?
Tumor Suppressor Protein p531201529370.020 Why?
Alleles1199669520.020 Why?
Mitosis1201012460.020 Why?
Adaptor Proteins, Signal Transducing1201529470.020 Why?
Embryo, Mammalian1199017220.020 Why?
HEK293 Cells1201342250.020 Why?
Cerebral Arteries119864920.020 Why?
Female420133754490.010 Why?
Dementia1199623840.010 Why?
Body Weight1201346570.010 Why?
Nerve Tissue11982770.010 Why?
Neoplasms12010209410.010 Why?
Biological Transport, Active119823490.010 Why?
Embryonic Stem Cells1200813280.010 Why?
Carrier Proteins2200850410.010 Why?
Caspase 1212000110.010 Why?
Infant12002343370.010 Why?
Tunicamycin120001130.010 Why?
Lymphoma1200818580.010 Why?
beta-Transducin Repeat-Containing Proteins11999310.010 Why?
DNA Methylation1201343110.010 Why?
Child, Preschool12002404400.010 Why?
Cytotoxins120001550.010 Why?
Peptides1199143900.010 Why?
Glioma1199333180.010 Why?
Surface Properties1198211670.010 Why?
Intracellular Membranes119794010.010 Why?
Cyclic AMP1198214760.010 Why?
Endoplasmic Reticulum, Smooth1199740.010 Why?
Fluorescent Antibody Technique, Direct11997710.010 Why?
Endocytosis119829920.010 Why?
Precipitin Tests119978510.010 Why?
Mutagenesis1200012750.010 Why?
Thymus Gland1200012620.010 Why?
Glutathione Transferase119976030.010 Why?
Cadherins119999110.010 Why?
Child12002751630.010 Why?
Adolescent12002844010.010 Why?
Microtubule-Associated Proteins1199911070.010 Why?
Time Factors11993401860.010 Why?
Oxazines119922960.010 Why?
Benzoxazines119923000.010 Why?
Recombinant Fusion Proteins1199938000.010 Why?
Macaca fascicularis119929180.010 Why?
Immunoenzyme Techniques1199218080.010 Why?
Necrosis1199216260.010 Why?
Genes1199019200.000 Why?
Gene Expression1199778190.000 Why?
DNA1199772410.000 Why?
Binding, Competitive1198111680.000 Why?
Chick Embryo119819910.000 Why?
Base Sequence11990129910.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.