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Bruce A. Yankner, M.D.,Ph.D.

Concepts (407)

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Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Amyloid beta-Peptides35201932141.660 Why?
Alzheimer Disease30201972601.390 Why?
Aging19202183501.260 Why?
Repressor Proteins6202130631.220 Why?
Amyloid beta-Protein Precursor13201611361.160 Why?
Neurons31202293761.150 Why?
Hypothalamus2201710620.730 Why?
Caenorhabditis elegans Proteins320228570.680 Why?
Longevity3202210300.640 Why?
Amyloid820067200.600 Why?
Presenilins12016640.570 Why?
Brain222021252100.550 Why?
Neural Stem Cells220198940.490 Why?
Amnesia120152340.470 Why?
I-kappa B Kinase220182600.470 Why?
Stress, Physiological3202114260.440 Why?
Membrane Proteins14200680470.440 Why?
Oxidative Stress8201431350.440 Why?
Apoptosis11202199730.430 Why?
Hippocampus10201536290.430 Why?
Neurotoxins320022400.420 Why?
Neurodegenerative Diseases320169510.420 Why?
Nervous System320025650.410 Why?
Induced Pluripotent Stem Cells2201915970.410 Why?
Presenilin-11220086450.390 Why?
Nerve Degeneration820027810.390 Why?
Gene Regulatory Networks1201916990.380 Why?
Endopeptidases220057790.360 Why?
NF-kappa B3201725530.360 Why?
Transcription Factors42019119540.310 Why?
Peptide Fragments11201851120.300 Why?
Gonadotropin-Releasing Hormone1201311910.300 Why?
Nerve Growth Factors720005900.300 Why?
Presenilin-2620081090.300 Why?
Nerve Tissue Proteins6201345630.300 Why?
Cells, Cultured242018199110.300 Why?
Astrocytes4201812360.300 Why?
Animals5620221694530.280 Why?
DNA-Binding Proteins3201997360.270 Why?
Cerebral Cortex12200856940.270 Why?
Autophagy4201513140.260 Why?
tau Proteins4201816490.250 Why?
Neuroprotective Agents320149950.250 Why?
Signal Transduction92017237290.240 Why?
Histone Acetyltransferases120053580.240 Why?
Trans-Activators3200530470.230 Why?
Neurofibrillary Tangles420004210.230 Why?
Synapses4200817160.220 Why?
MicroRNAs2201736370.220 Why?
Gene Expression Regulation112021123100.220 Why?
Transfection9200560890.220 Why?
Down Syndrome320028060.220 Why?
Receptors, Cell Surface5200029180.210 Why?
DNA Damage3201524340.210 Why?
Amyloid Precursor Protein Secretases420166070.210 Why?
Protein Processing, Post-Translational4200020090.200 Why?
Nuclear Proteins4200859470.200 Why?
Active Transport, Cell Nucleus120024500.200 Why?
Plaque, Amyloid320006770.200 Why?
Oncogene Proteins120057570.200 Why?
Parkinson Disease2200526810.190 Why?
Evolution, Molecular1200819380.180 Why?
Mice242022803760.180 Why?
Nuclear Lamina12019460.180 Why?
Peptide Hydrolases120026220.180 Why?
Caspases220009490.180 Why?
Rats172008248760.170 Why?
Mice, 129 Strain120194010.170 Why?
Disease Progression22015132390.170 Why?
Oligonucleotides220215710.170 Why?
Congo Red21996460.170 Why?
Cell Membrane3200538790.170 Why?
Receptor-Interacting Protein Serine-Threonine Kinases120181210.160 Why?
Humans6120227159140.160 Why?
Protein Precursors3199111830.160 Why?
Gene Expression Profiling3202195050.160 Why?
Cognition Disorders2201039750.160 Why?
Podocytes120214050.150 Why?
Mice, Knockout72019150580.150 Why?
Spastic Paraplegia, Hereditary119981310.150 Why?
Forkhead Transcription Factors2202215960.140 Why?
Mice, Transgenic4201998490.140 Why?
Cell Line132021165770.140 Why?
Mutation82008293010.140 Why?
Calcium2200658040.140 Why?
Axons3201817350.140 Why?
Cytoskeletal Proteins2199914130.140 Why?
Apolipoproteins E2201914420.140 Why?
Neurofibrils11995770.140 Why?
Pheochromocytoma619913380.140 Why?
Dopamine1200215930.130 Why?
GATA4 Transcription Factor120151360.130 Why?
In Situ Hybridization, Fluorescence1202126480.130 Why?
RNA-Binding Proteins2201918890.130 Why?
Tumor Cells, Cultured6200264850.130 Why?
Apolipoprotein E4120186130.130 Why?
Caenorhabditis elegans2202214100.130 Why?
Cyclin-Dependent Kinases220106720.130 Why?
Synucleins220051120.130 Why?
Adaptation, Physiological1202113340.130 Why?
Single-Cell Analysis2202221300.120 Why?
Mitochondria2201036130.120 Why?
Qc-SNARE Proteins12013220.120 Why?
Autistic Disorder1202210680.120 Why?
Cell Differentiation82019116560.120 Why?
Langerhans Cells119941770.120 Why?
RNA, Messenger22008132150.120 Why?
Exosomes120174030.120 Why?
Ubiquitin-Activating Enzymes12013700.120 Why?
RNA2202126140.120 Why?
CA3 Region, Hippocampal12013610.120 Why?
Species Specificity3200825990.110 Why?
Cell Death2201417240.110 Why?
Phagosomes120142070.110 Why?
Neuroglia120189200.110 Why?
RNA Interference2201929850.110 Why?
Transcription, Genetic3200878870.110 Why?
Lewy Body Disease120142040.110 Why?
Cell Nucleus4201429960.110 Why?
Neurogenesis120198210.110 Why?
Fibroblasts3201942330.110 Why?
Frontotemporal Dementia120142090.110 Why?
Ubiquitination220139890.110 Why?
DNA Repair3201320360.100 Why?
Phosphorylation7201886580.100 Why?
Antioxidants3200816710.100 Why?
Islet Amyloid Polypeptide31996420.100 Why?
Aspartic Acid Endopeptidases220053290.100 Why?
Histone Demethylases120132970.100 Why?
Chromatin Immunoprecipitation120149000.100 Why?
Suppressor of Cytokine Signaling Proteins120111800.100 Why?
Solubility3200011370.100 Why?
Tachykinins11990800.100 Why?
Reactive Oxygen Species2201021010.100 Why?
Substance P119913350.100 Why?
Protein Transport1201620540.100 Why?
Synaptic Transmission3201811910.090 Why?
Cell Survival4202160360.090 Why?
Mice, Inbred C57BL62019226640.090 Why?
Aged, 80 and over72021583280.090 Why?
Inflammation22015100860.090 Why?
Protein Structure, Tertiary3201339640.090 Why?
Protein Kinase C1199312690.090 Why?
Phosphoproteins3201825380.080 Why?
HeLa Cells4201332130.080 Why?
Peroxiredoxins12008510.080 Why?
PC12 Cells320003520.080 Why?
alpha-Synuclein220056770.080 Why?
Amino Acids1199317120.080 Why?
Cell Adhesion2199232650.080 Why?
Ubiquitin-Protein Ligases2201318430.080 Why?
Thioredoxins120082100.080 Why?
Dendrites119905440.070 Why?
Subcellular Fractions220055640.070 Why?
Receptor, Notch1220005200.070 Why?
Proteins4200860720.070 Why?
Fetus3200218530.070 Why?
Cerebral Arterial Diseases11986870.070 Why?
Down-Regulation1201430660.070 Why?
Transcriptional Activation2200518390.070 Why?
Octamer Transcription Factors12005170.070 Why?
Nerve Regeneration120118010.070 Why?
Epitopes2199726490.070 Why?
PTEN Phosphohydrolase1201111610.070 Why?
Sirtuins120083670.070 Why?
Gene Expression Regulation, Developmental1199737710.070 Why?
Nuclear Matrix-Associated Proteins12005440.070 Why?
Amygdala1201312600.070 Why?
Aged820211625180.070 Why?
Heparin1199216200.070 Why?
Golgi Apparatus219984310.060 Why?
Genomic Instability120086890.060 Why?
Up-Regulation1201443130.060 Why?
Granuloma119863300.060 Why?
Copper120063810.060 Why?
Cats2199610340.060 Why?
Phosphatidylinositol 3-Kinases2201029390.060 Why?
Histones1201325510.060 Why?
Antibodies1199124330.060 Why?
Biological Transport3199921210.060 Why?
Neurites219973900.060 Why?
Carbonyl Cyanide m-Chlorophenyl Hydrazone12002250.060 Why?
Endoplasmic Reticulum2200011990.060 Why?
Uncoupling Agents12002470.060 Why?
Receptors, N-Methyl-D-Aspartate120088910.060 Why?
Vasculitis119865150.060 Why?
Genes, Recessive120056600.060 Why?
Zinc120066930.050 Why?
Purines120055890.050 Why?
Gene Deletion2200028240.050 Why?
Insulin-Like Growth Factor I1201020280.050 Why?
Blotting, Western2200853800.050 Why?
Nervous System Diseases1199216470.050 Why?
Carbocyanines120021970.050 Why?
Homeostasis2202133360.050 Why?
Tyrosine 3-Monooxygenase120023750.050 Why?
14-3-3 Proteins120022200.050 Why?
Phylogeny1200827820.050 Why?
Sclerosis120211990.050 Why?
Apoptosis Regulatory Proteins1200611160.050 Why?
Chromosomes, Human, Pair 16120223400.050 Why?
RNA, Small Interfering2201335750.050 Why?
Fluorescent Antibody Technique1200526470.050 Why?
In Situ Nick-End Labeling120026630.050 Why?
Genes, Reporter1200516030.050 Why?
Calcium-Calmodulin-Dependent Protein Kinases219995010.050 Why?
Receptors, Notch120057540.050 Why?
Recombinant Proteins4200268030.050 Why?
Substantia Nigra120023570.050 Why?
Microglia2201811680.050 Why?
Glycogen Synthase Kinase 3219994400.050 Why?
Intracellular Signaling Peptides and Proteins2201329770.050 Why?
Chromosome Disorders120224960.050 Why?
Biopolymers120001910.050 Why?
Microscopy, Confocal1200520340.040 Why?
HIV1198615250.040 Why?
Receptors, Drug119791610.040 Why?
Microscopy, Fluorescence2199828070.040 Why?
Promoter Regions, Genetic2201560100.040 Why?
Callithrix11998940.040 Why?
Islets of Langerhans2199614090.040 Why?
Protease Inhibitors219937840.040 Why?
Apolipoprotein E312018920.040 Why?
Molecular Sequence Data52008185920.040 Why?
Adenomatous Polyposis Coli Protein119981770.040 Why?
Nuclear Envelope119791770.040 Why?
Superoxide Dismutase120006000.040 Why?
Diabetes Mellitus1199654680.040 Why?
Cytoskeleton2202112190.040 Why?
Staurosporine120182540.040 Why?
Chromosome Deletion1202213730.040 Why?
Chromatin1200826870.040 Why?
Receptors, Nerve Growth Factor319901980.040 Why?
Albuminuria120216740.040 Why?
Cognition1201460790.040 Why?
Epigenesis, Genetic1201034290.040 Why?
DNA Breaks, Double-Stranded220135800.040 Why?
Lysosomes220108940.040 Why?
Benzimidazoles120028770.040 Why?
beta Catenin2199910370.040 Why?
Tissue Distribution2199724000.040 Why?
Amino Acid Sequence41993141620.040 Why?
Xenopus Proteins119994520.040 Why?
Adult820212123290.040 Why?
Cell Line, Tumor32013167370.040 Why?
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins12015410.040 Why?
Fluoresceins119952400.040 Why?
Dactinomycin119953240.040 Why?
Cycloheximide119953530.040 Why?
Intracellular Fluid119952110.040 Why?
Neuronal Plasticity1200414060.030 Why?
Interleukin-1alpha12015850.030 Why?
Embryo, Nonmammalian119999540.030 Why?
Morphogenesis119997790.030 Why?
Oligonucleotide Array Sequence Analysis1200440400.030 Why?
Xenopus laevis1199910100.030 Why?
Learning1200416040.030 Why?
Insulin1201066550.030 Why?
Phosphoserine119952200.030 Why?
Free Radical Scavengers119952260.030 Why?
GTP-Binding Proteins119999710.030 Why?
Lipid Peroxidation119953120.030 Why?
Molecular Weight1199724130.030 Why?
Body Patterning119996500.030 Why?
Receptors, Amino Acid11993300.030 Why?
Rats, Sprague-Dawley2199785520.030 Why?
Phorbol Esters119931150.030 Why?
Enzyme Inhibitors1200538980.030 Why?
Sequence Analysis, RNA1202220160.030 Why?
Fluorescent Dyes1200219740.030 Why?
Diglycerides119931800.030 Why?
Models, Biological1201098110.030 Why?
Sequence Deletion1199815500.030 Why?
Hydrolysis119946840.030 Why?
SNARE Proteins120131000.030 Why?
Middle Aged420192147570.030 Why?
Genes, Lethal120132550.030 Why?
Tetradecanoylphorbol Acetate119938650.030 Why?
Immunohistochemistry32003116890.030 Why?
Organoids120186690.030 Why?
Kinetics3199566560.030 Why?
S Phase120134360.030 Why?
Young Adult22021562300.030 Why?
Kidney2200568840.030 Why?
Nerve Crush12011830.030 Why?
Huntington Disease1199911830.030 Why?
Organ Specificity1199720340.030 Why?
Cyclin-Dependent Kinase Inhibitor p16120157280.030 Why?
Enzyme Activation2200038180.030 Why?
Energy Metabolism2201329700.030 Why?
Stem Cells1200535690.030 Why?
Exons1199824660.030 Why?
Membrane Glycoproteins1200338240.030 Why?
Macaca mulatta1199824330.030 Why?
Carcinogens119934520.030 Why?
Chromogranins119921740.030 Why?
Dendritic Spines120132370.030 Why?
Histocytochemistry119927560.030 Why?
Genome-Wide Association Study12010119420.030 Why?
Protein Stability120135670.030 Why?
Male620153504110.030 Why?
Radiation Tolerance120135090.030 Why?
Cell Growth Processes120114030.030 Why?
Phenotype22021163180.030 Why?
Locomotion120133760.020 Why?
Diabetes Mellitus, Type 211994110890.020 Why?
Optic Nerve Injuries120111590.020 Why?
Oxidation-Reduction1199623020.020 Why?
Amyotrophic Lateral Sclerosis1200013620.020 Why?
GAP-43 Protein119901530.020 Why?
Behavior, Animal1201818880.020 Why?
Vesicular Transport Proteins120133810.020 Why?
Rats, Inbred Strains1199122600.020 Why?
Dose-Response Relationship, Drug21994112020.020 Why?
Cerebellum1199714790.020 Why?
Spinal Cord1201818100.020 Why?
Adrenal Gland Neoplasms319917350.020 Why?
Models, Neurological1199817810.020 Why?
Temperature1199521460.020 Why?
Lipid Metabolism1201819900.020 Why?
Restriction Mapping119899080.020 Why?
Specific Pathogen-Free Organisms120082320.020 Why?
Structure-Activity Relationship1199432060.020 Why?
Microtubules1199512080.020 Why?
Oxidoreductases Acting on Sulfur Group Donors12008300.020 Why?
Optic Nerve120115530.020 Why?
Fibroblast Growth Factor 2119906280.020 Why?
Embryonic Development120137070.020 Why?
Platelet-Derived Growth Factor119906420.020 Why?
Peroxidases120081440.020 Why?
Nucleic Acid Hybridization1198914350.020 Why?
Yeasts120082900.020 Why?
Adenosine Triphosphate1199420230.020 Why?
Epidermal Growth Factor119907230.020 Why?
Blotting, Northern1198916250.020 Why?
Protein Binding1200095600.020 Why?
STAT3 Transcription Factor120118910.020 Why?
BRCA1 Protein1201310470.020 Why?
Microfilament Proteins1201312100.020 Why?
Cell Count1199119120.020 Why?
Cell Cycle1201529930.020 Why?
Sirtuin 1120083030.020 Why?
Thymus Neoplasms120082540.020 Why?
Tumor Necrosis Factor-alpha1201844590.020 Why?
Oxygen Consumption1201319300.020 Why?
Social Behavior1201311030.020 Why?
Drug Synergism1199018540.020 Why?
Brain Chemistry1199010150.020 Why?
Retinal Ganglion Cells120117640.020 Why?
Homosexuality119862700.020 Why?
Immunoblotting1198917710.020 Why?
Memory Disorders1201311410.020 Why?
Gene Knockout Techniques120088090.020 Why?
Analysis of Variance1199465040.020 Why?
Tumor Suppressor Protein p531201529470.020 Why?
Mitosis1201012480.020 Why?
Alleles1199671010.020 Why?
Adaptor Proteins, Signal Transducing1201529720.020 Why?
Embryo, Mammalian1199017490.020 Why?
HEK293 Cells1201342670.020 Why?
Cerebral Arteries119864980.020 Why?
Dementia1199622590.010 Why?
Female420133773340.010 Why?
Neoplasms12010205280.010 Why?
Nerve Tissue11982750.010 Why?
Body Weight1201346920.010 Why?
Biological Transport, Active119823540.010 Why?
Embryonic Stem Cells1200813730.010 Why?
Caspase 1212000110.010 Why?
Carrier Proteins2200851020.010 Why?
Tunicamycin120001170.010 Why?
Infant12002345680.010 Why?
DNA Methylation1201340780.010 Why?
Lymphoma1200818810.010 Why?
beta-Transducin Repeat-Containing Proteins11999320.010 Why?
Cytotoxins120001540.010 Why?
Glioma1199333020.010 Why?
Peptides1199143830.010 Why?
Child, Preschool12002411990.010 Why?
Surface Properties1198211790.010 Why?
Intracellular Membranes119794070.010 Why?
Endoplasmic Reticulum, Smooth1199740.010 Why?
Cyclic AMP1198215050.010 Why?
Fluorescent Antibody Technique, Direct11997720.010 Why?
Endocytosis1198210060.010 Why?
Disease Models, Animal11996182020.010 Why?
Precipitin Tests119978930.010 Why?
Mutagenesis1200012810.010 Why?
Thymus Gland1200013170.010 Why?
Glutathione Transferase119976180.010 Why?
Cadherins119999130.010 Why?
Child12002744600.010 Why?
Adolescent12002851550.010 Why?
Microtubule-Associated Proteins1199911040.010 Why?
Benzoxazines119922940.010 Why?
Oxazines119922980.010 Why?
Time Factors11993409030.010 Why?
Recombinant Fusion Proteins1199938440.010 Why?
Macaca fascicularis119929510.010 Why?
Immunoenzyme Techniques1199218330.010 Why?
Necrosis1199216450.010 Why?
Genes1199019650.000 Why?
Gene Expression1199779540.000 Why?
DNA1199771000.000 Why?
Binding, Competitive1198111990.000 Why?
Chick Embryo119819720.000 Why?
Base Sequence11990131800.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.