Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Kevin James Croce, M.D.,Ph.D.

Concepts (509)

Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Calgranulin B112020861.770 Why?
Plaque, Atherosclerotic15202415321.360 Why?
Calgranulin A72015801.330 Why?
Coronary Angiography18202444711.010 Why?
Blood Platelets11201624790.840 Why?
Angioplasty, Balloon, Coronary6201517250.800 Why?
Coronary Artery Disease18202464030.790 Why?
Macrophages14202057670.740 Why?
Endothelium, Vascular14202344310.740 Why?
Coronary Restenosis320183960.700 Why?
Tomography, Optical Coherence9202429170.690 Why?
Platelet Aggregation Inhibitors7201727510.660 Why?
Cell-Derived Microparticles120201610.630 Why?
Atherosclerosis12202234070.600 Why?
Coronary Occlusion420223040.600 Why?
Thrombosis9202029420.600 Why?
Coronary Vessels12202430960.560 Why?
Lipoproteins, LDL120206420.560 Why?
Platelet Aggregation320137710.480 Why?
Tunica Intima720184590.480 Why?
Myocardial Infarction122022114610.460 Why?
Ticlopidine420177300.440 Why?
Endothelial Cells10202135490.420 Why?
Thrombin220205910.380 Why?
Thiophenes220125690.340 Why?
Femoral Artery420108260.330 Why?
Coronary Stenosis220167940.330 Why?
Platelet Function Tests120112710.320 Why?
Aryl Hydrocarbon Hydroxylases120102440.310 Why?
Thromboplastin320202860.290 Why?
Membrane Glycoproteins5201037010.290 Why?
Heart Valve Prosthesis1201614620.290 Why?
P-Selectin520115970.280 Why?
Neovascularization, Physiologic4201913490.280 Why?
Mice, Inbred C57BL302020221740.280 Why?
Toll-Like Receptors120105890.270 Why?
von Willebrand Factor120106730.270 Why?
Stents8202231790.260 Why?
Aortic Valve1201619550.260 Why?
Chest Pain1201210910.250 Why?
Chemotaxis, Leukocyte420126620.250 Why?
Inflammation132015107740.250 Why?
Vasculitis120095210.240 Why?
Coronary Circulation2202415690.240 Why?
Drug Monitoring120119620.240 Why?
Macrophage-1 Antigen320122850.230 Why?
Tetrazoles120109090.230 Why?
Acute Coronary Syndrome4201321900.220 Why?
Neutrophil Infiltration320173900.220 Why?
Piperazines2201225230.220 Why?
Terminology as Topic1201115300.220 Why?
Platelet Glycoprotein GPIb-IX Complex320101440.220 Why?
Aspirin3201731330.210 Why?
Hemorrhage3201734240.210 Why?
Early Growth Response Transcription Factors22013320.200 Why?
Mice, Knockout202017144170.200 Why?
Drug-Eluting Stents420176810.200 Why?
Mice402021815390.190 Why?
E-Selectin420155760.190 Why?
Purinergic P2Y Receptor Antagonists320162840.190 Why?
Collagen Type IV120211260.190 Why?
Platelet Adhesiveness220081540.180 Why?
Myocytes, Smooth Muscle320166990.180 Why?
Kruppel-Like Transcription Factors320135040.180 Why?
Lithotripsy120211400.180 Why?
Carotid Artery Diseases520188770.180 Why?
MicroRNAs4201938160.180 Why?
Heart Injuries120222060.170 Why?
Pyridazines120222020.170 Why?
Humans7720247615960.170 Why?
Adenosine220158080.160 Why?
Calpain119991460.160 Why?
Immunity, Innate2201230660.160 Why?
Hemodynamics3202041600.160 Why?
Animals4620211684750.160 Why?
Leukocyte Rolling22015690.150 Why?
Graft Rejection1201144460.150 Why?
Neutrophils5201837670.150 Why?
Heart Transplantation1201132330.150 Why?
Cardiovascular Diseases42011155020.150 Why?
Receptors, IgG320125590.150 Why?
Arterial Occlusive Diseases120227480.150 Why?
Hydrolases120181470.140 Why?
Signal Transduction122019234470.140 Why?
Drug Carriers120217060.140 Why?
Leukocytes4201120260.140 Why?
Myeloid Progenitor Cells320121130.140 Why?
Leukemia, Myelogenous, Chronic, BCR-ABL Positive120226860.140 Why?
Cell Adhesion6201430880.140 Why?
Enzyme Inhibitors2202137130.140 Why?
Protein Tyrosine Phosphatase, Non-Receptor Type 6120161200.140 Why?
Fractional Flow Reserve, Myocardial120203230.140 Why?
Flow Cytometry5202058700.140 Why?
Treatment Outcome182022646850.130 Why?
Forkhead Transcription Factors3201516160.130 Why?
Ultrasonography, Interventional5202314960.130 Why?
Bone Marrow Cells3201324170.130 Why?
Muscle, Smooth, Vascular3201614920.130 Why?
Nitric Oxide Synthase Type III120197050.130 Why?
Neovascularization, Pathologic2201926450.130 Why?
Catheterization, Peripheral120193430.130 Why?
Drug Resistance2201315960.130 Why?
Anterior Wall Myocardial Infarction12016420.130 Why?
Imidazoles1202211800.130 Why?
p38 Mitogen-Activated Protein Kinases120196870.130 Why?
Hyperplasia2201611520.130 Why?
Monocytes3200925700.130 Why?
Oxygenases12015590.120 Why?
Cell Proliferation82019104510.120 Why?
Adenosine Monophosphate120162310.120 Why?
Granulocyte-Macrophage Progenitor Cells22011210.120 Why?
Toll-Like Receptor 2120173470.120 Why?
Male3620243608460.120 Why?
NF-kappa B p50 Subunit120141030.120 Why?
Synovitis120152170.120 Why?
S-Nitrosothiols12014350.110 Why?
Cell Movement6201952050.110 Why?
Collagen2201326380.110 Why?
Ulcer120152040.110 Why?
Graft Occlusion, Vascular120175370.110 Why?
Antiphospholipid Syndrome120151650.110 Why?
Nitric Oxide Donors120141260.110 Why?
Smad1 Protein12013810.110 Why?
Arthritis, Experimental120152910.110 Why?
Transcription Factor RelA120142540.110 Why?
Integrin alpha4beta1120131190.110 Why?
Diabetes Complications1202013150.110 Why?
Blood Flow Velocity1201713710.110 Why?
Ossification, Heterotopic120152350.110 Why?
Annexin A5120131030.110 Why?
Cytoplasmic Vesicles12013730.110 Why?
Nanoparticles3202119580.100 Why?
Algorithms42022140330.100 Why?
Carotid Artery Injuries12013960.100 Why?
Precursor Cell Lymphoblastic Leukemia-Lymphoma1202215510.100 Why?
Protein Kinase Inhibitors2202256720.100 Why?
Salicylates120131270.100 Why?
Lymphocyte Function-Associated Antigen-1120133770.100 Why?
Internationality1201710010.100 Why?
Peripheral Arterial Disease2202112730.100 Why?
Mesenchymal Stem Cell Transplantation120174990.100 Why?
Th17 Cells220157940.100 Why?
Matrix Metalloproteinase 13120111020.100 Why?
Paracrine Communication120132770.100 Why?
Leukocyte L1 Antigen Complex12011930.100 Why?
Cells, Cultured102021189660.090 Why?
Lymphocyte Culture Test, Mixed120115090.090 Why?
Antibodies3201224180.090 Why?
Serum120122090.090 Why?
Disease Models, Animal112021182550.090 Why?
RNA, Messenger52015127940.090 Why?
Receptors, Retinoic Acid120112240.090 Why?
Apolipoprotein C-III120122110.090 Why?
Apolipoproteins E5201514430.090 Why?
Antigen-Antibody Complex120125100.090 Why?
Histocompatibility120113170.090 Why?
Proto-Oncogene Proteins c-akt1201924570.090 Why?
Clinical Trials as Topic3201180020.090 Why?
Nanotechnology220217140.090 Why?
Middle Aged1620242209210.090 Why?
Shear Strength120101600.090 Why?
Glutathione Peroxidase120112580.090 Why?
Cathepsins120112410.080 Why?
Vascular System Injuries120132460.080 Why?
Drug Approval120168140.080 Why?
Brachytherapy1201712230.080 Why?
Tumor Necrosis Factor-alpha4201443520.080 Why?
Microbubbles120101350.080 Why?
Cholesterol, LDL2201523820.080 Why?
Female2320243927050.080 Why?
Albumins120125750.080 Why?
T-Box Domain Proteins120114690.080 Why?
Transcription Factors32014121300.080 Why?
Coccidiostats1200830.080 Why?
Sulfadiazine12008180.080 Why?
Heart-Assist Devices1201912870.080 Why?
Aorta2201320410.080 Why?
Coronary Thrombosis120114400.080 Why?
Aged1220241693100.080 Why?
Gadolinium DTPA120128230.080 Why?
Matrix Metalloproteinases120113930.080 Why?
Bone Morphogenetic Proteins120138420.080 Why?
Endocytosis120129570.080 Why?
Cardiovascular System120158340.070 Why?
Hepatocytes1201512330.070 Why?
Tyrosine1201214400.070 Why?
NF-kappa B2201324900.070 Why?
Osteoarthritis1201510630.070 Why?
Infarction, Middle Cerebral Artery120114850.070 Why?
Wound Healing1201928050.070 Why?
Transforming Growth Factor beta1120116290.070 Why?
Metal Nanoparticles120123990.070 Why?
Cadherins120129030.070 Why?
Histocompatibility Antigens Class II1201114350.070 Why?
Ureteral Calculi120081140.070 Why?
Peripheral Vascular Diseases120104880.070 Why?
Quinolines120127650.070 Why?
Drug Therapy, Combination3201563120.070 Why?
Adiponectin1201211130.070 Why?
Standard of Care120105510.070 Why?
Th1 Cells1201210360.070 Why?
Heart Diseases1201927810.070 Why?
Randomized Controlled Trials as Topic32022102120.070 Why?
Platelet Activation120106450.070 Why?
Ligands4201532720.070 Why?
Mice, Mutant Strains1200917490.070 Why?
Magnetics120095990.070 Why?
Hypertension, Pulmonary1201715780.070 Why?
Interleukin-17120129120.070 Why?
Hindlimb320145130.060 Why?
Ischemia2201118840.060 Why?
Heptanoic Acids120073440.060 Why?
Pravastatin120073920.060 Why?
Leukocytes, Mononuclear1201218440.060 Why?
Comparative Effectiveness Research120107090.060 Why?
Drug Interactions1201014160.060 Why?
Predictive Value of Tests42023152660.060 Why?
Patient Care Planning120109090.060 Why?
Protein Binding4202193530.060 Why?
Intercellular Signaling Peptides and Proteins1201216510.060 Why?
Clinical Protocols1201014400.060 Why?
Proton Pump Inhibitors120105320.060 Why?
Emergency Medical Services2201519230.060 Why?
Aged, 80 and over52022589840.060 Why?
Calcinosis1201314690.060 Why?
Thrombolytic Therapy2201020640.060 Why?
Guidelines as Topic1201013860.060 Why?
Bone Marrow Transplantation3201826930.060 Why?
Immunoconjugates120129530.060 Why?
T-Lymphocyte Subsets1201218020.060 Why?
Blotting, Western3201650350.060 Why?
Myocardium1201747250.060 Why?
Solubility2201210910.060 Why?
Practice Guidelines as Topic2201973910.060 Why?
Kidney Calculi120084630.060 Why?
Molecular Targeted Therapy1201528110.060 Why?
Tissue Distribution2202122640.050 Why?
Transplantation, Homologous1201148070.050 Why?
Biosensing Techniques120096500.050 Why?
Mice, Inbred BALB C1201162140.050 Why?
CD4-Positive T-Lymphocytes2201343690.050 Why?
Membrane Proteins3201378590.050 Why?
Cell Differentiation22011115300.050 Why?
Macrophage Activation220205530.050 Why?
Antibodies, Neutralizing1201219430.050 Why?
Image Interpretation, Computer-Assisted1201533590.050 Why?
Anti-Inflammatory Agents1201218090.050 Why?
Cytokines3201273960.050 Why?
Intracellular Signaling Peptides and Proteins1201228720.050 Why?
Calcium-Binding Proteins2201210690.050 Why?
Risk Factors72017742130.050 Why?
Liver2201575280.050 Why?
Chemotherapy, Adjuvant1201035140.050 Why?
Pyrroles1200711250.050 Why?
Culture Media, Conditioned220135220.050 Why?
Vascular Cell Adhesion Molecule-1220146910.050 Why?
Graft Survival1201138200.050 Why?
Basement Membrane120213490.050 Why?
Thrombectomy220157050.040 Why?
Drug Compounding120212460.040 Why?
Risk Assessment52015239960.040 Why?
Mice, Transgenic4201695420.040 Why?
Stem Cells1201335240.040 Why?
Antigens, CD34220136580.040 Why?
Amino Acid Sequence32005134460.040 Why?
Off-Label Use120211850.040 Why?
Lupus Erythematosus, Systemic1201221550.040 Why?
Nuclear Proteins1201457990.040 Why?
Vascular Endothelial Growth Factor Receptor-2220135460.040 Why?
Polymorphism, Genetic1201042430.040 Why?
Saphenous Vein220125160.040 Why?
Radial Artery120211870.040 Why?
Alkylation11998840.040 Why?
Molecular Sequence Data32005176350.040 Why?
T-Lymphocytes22013101940.040 Why?
Prospective Studies62022544230.040 Why?
Antineoplastic Agents12022136420.040 Why?
Surface Properties1202111610.040 Why?
Contrast Media1201253070.040 Why?
Patient Selection1201142440.040 Why?
Drug Administration Schedule2201748530.040 Why?
Fluorescence Polarization119981400.040 Why?
Catheters120214270.040 Why?
Calcium3201357220.040 Why?
Punctures120193660.040 Why?
Lipids1200933410.040 Why?
Collateral Circulation120192940.040 Why?
Cell Separation2201517200.040 Why?
Solutions119984120.040 Why?
Precipitin Tests119988130.040 Why?
CD8-Positive T-Lymphocytes1201145800.040 Why?
Vascular Endothelial Growth Factor A2201934920.040 Why?
Time Factors52022399690.040 Why?
T-Lymphocytes, Regulatory1201130800.040 Why?
Odds Ratio3202296470.040 Why?
Workflow120228510.040 Why?
Repressor Proteins1200829860.040 Why?
Exocytosis119993200.040 Why?
Antigens, CD2200640010.040 Why?
Hydroxymethylglutaryl-CoA Reductase Inhibitors1201232460.040 Why?
Deoxyribonuclease I120182240.040 Why?
Injections, Intra-Arterial120171820.040 Why?
Vascular Diseases1200511610.040 Why?
Gene Expression Regulation52014119040.040 Why?
Dimerization119988910.030 Why?
Kidney1201270480.030 Why?
Rats, Zucker120161310.030 Why?
Insulin Resistance3201639640.030 Why?
Diagnostic Imaging1201135300.030 Why?
Spectrometry, Fluorescence119986850.030 Why?
Cytoplasmic Granules119995740.030 Why?
DNA-Binding Proteins2201196100.030 Why?
CHO Cells1199813870.030 Why?
Intraoperative Period120165100.030 Why?
Peptides1200843580.030 Why?
Gene Expression Profiling2201594200.030 Why?
Phenotype22010165920.030 Why?
Chronic Disease2202193190.030 Why?
Diabetes Mellitus1201458410.030 Why?
Cholesterol, Dietary120152240.030 Why?
Intercellular Adhesion Molecule-12201211260.030 Why?
Lipid Metabolism, Inborn Errors120151230.030 Why?
Cricetinae1199824230.030 Why?
Phosphorylation2201983210.030 Why?
SOXF Transcription Factors12014310.030 Why?
Mice, Inbred NOD1201918270.030 Why?
Injections, Intravenous1201613790.030 Why?
Rabbits2201247720.030 Why?
Osteomyelitis120184070.030 Why?
Diabetes Mellitus, Experimental1202011190.030 Why?
Rats32016237410.030 Why?
Aldehyde Oxidoreductases12014880.030 Why?
Blood Pressure1200984810.030 Why?
Immunoprecipitation120158780.030 Why?
Follow-Up Studies42017391060.030 Why?
Receptors, CCR412013770.030 Why?
Lipopolysaccharides2201222060.030 Why?
Karyopherins120131330.030 Why?
Transendothelial and Transepithelial Migration120131000.030 Why?
Intradermal Tests12012420.030 Why?
Ventricular Function, Right120176170.030 Why?
Obesity12015129470.030 Why?
Cell Death1201816790.030 Why?
Tomography, X-Ray Computed22023205680.030 Why?
Azepines120143290.030 Why?
Oxidation-Reduction1199822310.030 Why?
Macrophages, Peritoneal120132380.030 Why?
Reverse Transcriptase Polymerase Chain Reaction2201245760.020 Why?
Cell Line22019156010.020 Why?
Zebrafish2201430080.020 Why?
Membrane Lipids120132520.020 Why?
Microscopy, Fluorescence2201326450.020 Why?
Phosphorus120133350.020 Why?
3T3-L1 Cells120122090.020 Why?
Phosphatidylserines120131880.020 Why?
Jurkat Cells120137400.020 Why?
Durapatite120131630.020 Why?
Chemokine CCL2012012640.020 Why?
Acetylation1201410550.020 Why?
Peptide Fragments2200551120.020 Why?
Brazil1201512300.020 Why?
Bleeding Time12011830.020 Why?
Mice, Obese120124200.020 Why?
NF-E2-Related Factor 2120143730.020 Why?
In Situ Hybridization, Fluorescence1201725100.020 Why?
Diabetes Mellitus, Type 212015121490.020 Why?
GPI-Linked Proteins120124700.020 Why?
Stress, Mechanical1201616740.020 Why?
Antibodies, Monoclonal1200891770.020 Why?
K562 Cells120126420.020 Why?
Regulatory Sequences, Nucleic Acid120147900.020 Why?
Extracellular Space120125630.020 Why?
Models, Cardiovascular120169810.020 Why?
Gene Knockdown Techniques1201516120.020 Why?
RNA Polymerase II120145390.020 Why?
Complement C3a12010660.020 Why?
Immunoblotting1201316460.020 Why?
Encephalomyelitis, Autoimmune, Experimental120158230.020 Why?
Chemotaxis120135980.020 Why?
Adenosine Diphosphate120114220.020 Why?
Prosthesis Design1201721150.020 Why?
Hyperlipidemias120157710.020 Why?
Gene Knock-In Techniques120114210.020 Why?
Heart1202344040.020 Why?
Complement C5a120101000.020 Why?
Receptor, Anaphylatoxin C5a12010870.020 Why?
Cyclic GMP120113950.020 Why?
Binding Sites1199860560.020 Why?
Platelet Glycoprotein GPIIb-IIIa Complex120125770.020 Why?
Carotid Stenosis120178600.020 Why?
Chemokine CCL2120126050.020 Why?
Cardiovascular Agents120168400.020 Why?
Acetaminophen120145550.020 Why?
Receptors, LDL120124880.020 Why?
Recombinant Proteins2201265340.020 Why?
Receptors, Complement120102530.020 Why?
Triazoles120149030.020 Why?
Survival Rate22017127230.020 Why?
Tumor Suppressor Proteins1201928050.020 Why?
Fibrosis1201620490.020 Why?
Glutathione120115830.020 Why?
Embryonic Development120137210.020 Why?
Disease Progression22016135100.020 Why?
Cholesterol, HDL1201518140.020 Why?
Cell Cycle1201629320.020 Why?
United States Food and Drug Administration1201616640.020 Why?
Toxoplasmosis12008940.020 Why?
United States32022723400.020 Why?
Chemokines120129590.020 Why?
Regional Blood Flow1201114960.020 Why?
Enhancer Elements, Genetic1201413630.020 Why?
Aortic Valve Insufficiency120125760.020 Why?
Placenta1201717090.020 Why?
Adult420222212100.020 Why?
Receptors, Notch120127440.020 Why?
Coculture Techniques1201113410.020 Why?
Zebrafish Proteins1201410150.020 Why?
Monitoring, Physiologic1201517790.020 Why?
Ferric Compounds120093780.020 Why?
Triglycerides1201524610.020 Why?
Transcription, Genetic2201475930.020 Why?
Swine1201759150.020 Why?
Fluorescence120097560.020 Why?
Neoplasms12015221730.020 Why?
Hyperglycemia1201513760.020 Why?
Mesenchymal Stem Cells1201716420.020 Why?
Sensitivity and Specificity22012146650.020 Why?
Muscle, Skeletal2201149480.020 Why?
Databases, Factual1202179680.020 Why?
Pyridines1201728750.020 Why?
Carrier Proteins1199949370.020 Why?
Registries1202182250.020 Why?
Adipocytes1201211940.020 Why?
Staining and Labeling1200910850.010 Why?
Nitric Oxide1201421360.010 Why?
Heart Ventricles1201738070.010 Why?
Administration, Oral1201240210.010 Why?
Stem Cell Transplantation1201316000.010 Why?
Transfection1201257740.010 Why?
RNA Interference1201328320.010 Why?
Autoimmunity1201213560.010 Why?
Sodium-Calcium Exchanger12004890.010 Why?
Cell Count1200818350.010 Why?
Sirolimus1201115330.010 Why?
Immunoglobulin G2200845440.010 Why?
Massachusetts1201788330.010 Why?
Histones1201425800.010 Why?
Antigens, Differentiation, T-Lymphocyte120068980.010 Why?
RNA, Small Interfering1201334300.010 Why?
Rats, Sprague-Dawley1201581810.010 Why?
Organ Specificity1200819680.010 Why?
Double-Blind Method12017123410.010 Why?
Incidence12022213550.010 Why?
Up-Regulation1201241250.010 Why?
Reactive Oxygen Species1201121390.010 Why?
HEK293 Cells1201242810.010 Why?
Antioxidants1201116680.010 Why?
Inflammation Mediators1201218860.010 Why?
Recurrence1201584660.010 Why?
Lectins, C-Type120065850.010 Why?
Fluorescent Dyes1201119030.010 Why?
Gene Expression Regulation, Neoplastic1201985540.010 Why?
Survival Analysis12015100900.010 Why?
Chromatin1201429610.010 Why?
Ventricular Dysfunction, Left1201321180.010 Why?
Hypoglycemic Agents1201530850.010 Why?
Pilot Projects1201586330.010 Why?
Young Adult22022592600.010 Why?
Probability1200724770.010 Why?
Statistics, Nonparametric1200828500.010 Why?
Confidence Intervals1200729270.010 Why?
Megakaryocytes120065670.010 Why?
Adaptor Proteins, Signal Transducing1201228980.010 Why?
Pregnancy22017298900.010 Why?
Cross-Linking Reagents120046870.010 Why?
Models, Animal1200821120.010 Why?
Down-Regulation1200829190.010 Why?
Feasibility Studies1201252470.010 Why?
Myocardial Ischemia1201121130.010 Why?
Retrospective Studies22022806470.010 Why?
Ventricular Function, Left1201338790.010 Why?
Insulin1201565970.010 Why?
Reference Values1200749200.010 Why?
Adipose Tissue1201233130.010 Why?
Anti-Infective Agents120079830.010 Why?
Promoter Regions, Genetic1201157900.010 Why?
Calcium Signaling120047330.010 Why?
Anticoagulants1201548120.010 Why?
Qc-SNARE Proteins11999200.010 Why?
Qb-SNARE Proteins11999340.010 Why?
Tetanus Toxin11999460.010 Why?
Qa-SNARE Proteins11999520.010 Why?
Image Processing, Computer-Assisted1201690010.010 Why?
Case-Control Studies22007221760.010 Why?
R-SNARE Proteins11999750.010 Why?
Magnetic Resonance Spectroscopy1200937690.010 Why?
Lasers120039520.010 Why?
Cell Communication1200516570.010 Why?
Microcirculation1200312720.010 Why?
Coronary Disease1201259140.010 Why?
Blood Coagulation1200311540.010 Why?
Genotype12011129900.010 Why?
Gene Targeting119998380.010 Why?
Acute Disease1200672370.010 Why?
Mutation11999300530.010 Why?
Prognosis12015296290.010 Why?
Models, Biological1200994690.010 Why?
Gene Deletion1199926650.010 Why?
Magnetic Resonance Imaging12012364260.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.