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Francis W. Luscinskas, Ph.D.

Concepts (518)

Concepts are derived automatically from a person's publications.
Concepts are listed by decreasing relevance which is based on many factors, including how many publications the person wrote about that topic, how long ago those publications were written, and how many publications other people have written on that same topic.
Name Number of Publications Most Recent Publication Publications by All Authors Concept Score Why?
Endothelium, Vascular65202044173.250 Why?
Cell Adhesion67202030932.510 Why?
Neutrophils38202037822.290 Why?
Cell Movement48202051971.940 Why?
Leukocytes21201620331.920 Why?
Cell Adhesion Molecules31201116121.510 Why?
Transendothelial and Transepithelial Migration720211001.500 Why?
Lymphocyte Function-Associated Antigen-1720203811.360 Why?
Cadherins1120129011.350 Why?
Monocytes22202125991.350 Why?
Intercellular Adhesion Molecule-123202111311.320 Why?
Chemotaxis, Leukocyte1120126611.310 Why?
E-Selectin2520145751.070 Why?
Endothelial Cells23201635761.020 Why?
Vascular Cell Adhesion Molecule-12420216921.010 Why?
Encephalomyelitis, Autoimmune, Experimental420218201.010 Why?
P-Selectin1320065980.910 Why?
Tumor Necrosis Factor-alpha27202143480.830 Why?
T-Lymphocytes192022102630.830 Why?
Integrin alpha4beta1820161190.820 Why?
Receptors, Immunologic5202214180.810 Why?
Antigens, CD23201540310.800 Why?
Inflammation252020108600.720 Why?
Lymphocyte Activation10202055020.720 Why?
Leukocyte Rolling42012690.710 Why?
Intercellular Junctions920131980.690 Why?
Th1 Cells8201210400.640 Why?
L-Selectin1120102120.540 Why?
Cortactin22006280.530 Why?
Macrophages8202157820.520 Why?
Spleen1202222940.510 Why?
Phagocytosis1202115270.510 Why?
Catenins32012440.500 Why?
Chemokines520169620.490 Why?
Cells, Cultured442020189790.490 Why?
Microscopy, Fluorescence3201426290.450 Why?
Cytokine Receptor gp13012013660.450 Why?
Antigens, Differentiation320199210.440 Why?
Chemokine CXCL1120131020.440 Why?
Integrins720108390.430 Why?
Membrane Glycoproteins10200737020.430 Why?
Animals8420221688870.420 Why?
Neutrophil Infiltration320123920.420 Why?
CD4-Positive T-Lymphocytes5201644100.420 Why?
Leukocyte Elastase220041130.410 Why?
Microglia1202113700.410 Why?
Umbilical Veins1320104230.410 Why?
Signal Transduction142021236110.400 Why?
Paxillin12012860.390 Why?
Mice, Knockout232021144660.390 Why?
Proto-Oncogene Proteins pp60(c-src)120121470.390 Why?
Endothelium220127680.380 Why?
Chemokines, CXC420064200.380 Why?
Receptors, Chemokine420116520.380 Why?
rhoA GTP-Binding Protein220122340.380 Why?
Mice, Inbred C57BL262022223370.380 Why?
Focal Adhesion Protein-Tyrosine Kinases120121830.370 Why?
Capillary Permeability320127700.360 Why?
Mice502022818630.350 Why?
Cell Communication11202216580.340 Why?
Tyrosine2201214250.340 Why?
Mast Cells3201114050.340 Why?
Guanine Nucleotide Exchange Factors420205720.330 Why?
Th2 Cells5200310780.330 Why?
Models, Immunological220095170.320 Why?
Receptors, Lymphocyte Homing320001410.310 Why?
Receptors, Antigen, T-Cell6202225700.310 Why?
T-Lymphocyte Subsets3201218140.310 Why?
Atherosclerosis6201934180.310 Why?
Trans-Activators4200428540.310 Why?
Albumins120115780.310 Why?
Ligands12201232760.310 Why?
Dendritic Cells4202227470.300 Why?
Interleukin-8620047010.270 Why?
Hypersensitivity, Delayed220074910.270 Why?
src-Family Kinases220065400.270 Why?
Immunoglobulins220078530.270 Why?
Cell Fractionation120062450.250 Why?
T-Box Domain Proteins220074710.240 Why?
Wiskott-Aldrich Syndrome Protein220161630.240 Why?
Flow Cytometry14201958900.240 Why?
Staphylococcal Infections1201413960.240 Why?
Actins5201420600.220 Why?
Receptors, IgG320195620.210 Why?
Blood Vessels2200711110.210 Why?
Receptor, Interferon alpha-beta220211130.210 Why?
Membrane Proteins7202178660.210 Why?
Hemorheology420071440.200 Why?
Interleukin-12320015810.200 Why?
N-Acetylglucosaminyltransferases320021680.190 Why?
Phosphorylation6201283000.190 Why?
Stem Cells2200735380.190 Why?
Skin3201644980.190 Why?
Cytoskeletal Proteins4201613240.190 Why?
Immunity, Innate2202130780.180 Why?
Neutrophil Activation420201800.180 Why?
Interleukin-18200412510.180 Why?
Bone Marrow Cells2200824130.170 Why?
B-Lymphocytes4202047840.160 Why?
Disease Models, Animal62021183220.160 Why?
Phosphoproteins1200824460.160 Why?
Humans9620207664320.160 Why?
Mice, Inbred BALB C11202062170.160 Why?
Shear Strength320091600.160 Why?
Eosinophils320209520.160 Why?
Chemokines, CC120002850.160 Why?
Adoptive Transfer420168280.160 Why?
Matrix Metalloproteinase 9120026330.160 Why?
Cathepsin G12018410.160 Why?
Protein Binding8201693150.150 Why?
CHO Cells6199913760.150 Why?
Microtubule-Associated Proteins2201510710.150 Why?
Interleukin-1alpha12018880.150 Why?
Antibodies, Monoclonal14201692430.150 Why?
Galectins120202950.150 Why?
Nephritis220151460.140 Why?
Germinal Center120203790.140 Why?
Cysteine Endopeptidases219975420.140 Why?
Microvessels220135860.140 Why?
Cricetinae6199924160.140 Why?
Interferon Type I120215680.140 Why?
Myocardium3202047630.140 Why?
Image Processing, Computer-Assisted1201489250.140 Why?
Jurkat Cells320137390.140 Why?
Lymphoma, T-Cell120193080.140 Why?
Green Fluorescent Proteins4200820620.140 Why?
Multienzyme Complexes219976630.140 Why?
Paracrine Communication120182770.140 Why?
Platelet Membrane Glycoproteins219952820.140 Why?
Immunomodulation120205480.140 Why?
Recombinant Fusion Proteins7200837360.130 Why?
Thromboplastin120182890.130 Why?
Antigens1202214410.130 Why?
Lymph Nodes3201634660.130 Why?
Apolipoproteins C22006590.130 Why?
Sialomucins12016180.130 Why?
rap1 GTP-Binding Proteins22007510.130 Why?
Transfection6200557500.130 Why?
Antibody Formation1202013920.130 Why?
A Kinase Anchor Proteins12015570.120 Why?
Diffusion Chambers, Culture32001490.120 Why?
Apolipoprotein C-III320122090.120 Why?
Mice, Transgenic5202295390.120 Why?
Leukocytosis119962490.120 Why?
Receptors, Cell Surface2201528150.110 Why?
NF-kappa B p50 Subunit120141030.110 Why?
Cytoskeleton3200911790.110 Why?
Hydroxamic Acids119974830.110 Why?
Interleukin-45202011550.110 Why?
Transcription Factor RelA120142520.110 Why?
Interferon Regulatory Factor-112013690.110 Why?
Interferon-gamma1200131590.110 Why?
Adaptor Proteins, Vesicular Transport220123000.110 Why?
Intestines2202019040.110 Why?
Blood Coagulation2201811620.100 Why?
Protein Transport3202019400.100 Why?
Hydroxyeicosatetraenoic Acids219902250.100 Why?
Immunization1201612180.100 Why?
Carrier Proteins2201649240.100 Why?
Calcium5201357810.100 Why?
Arteriosclerosis1199610550.100 Why?
Chemotactic Factors119921970.100 Why?
Macrophage-1 Antigen420032860.100 Why?
Myocytes, Cardiac1202016740.100 Why?
Granulocytes119935510.100 Why?
Recombinant Proteins4201265070.090 Why?
Antigen Presentation1201612510.090 Why?
Blood Flow Velocity3200813740.090 Why?
Gene Expression Regulation82016119190.090 Why?
Receptors, Tumor Necrosis Factor, Type II120133470.090 Why?
Interferon-beta120133480.090 Why?
Image Enhancement1200128560.090 Why?
Leukocytes, Mononuclear3201218510.090 Why?
Integrin alpha422002890.090 Why?
Immunoblotting1201316460.090 Why?
RNA, Small Interfering3201634240.090 Why?
Cell Proliferation32016104380.090 Why?
Cell Culture Techniques3201316470.090 Why?
Killer Cells, Natural1201922100.090 Why?
Myeloid Cells120158380.080 Why?
Cell Membrane Permeability220015680.080 Why?
Cell Migration Inhibition22006970.080 Why?
Tight Junctions220023320.080 Why?
Fucosyltransferases420061180.080 Why?
Chemotaxis320205980.080 Why?
Reperfusion Injury1201510430.080 Why?
Lung22006100640.080 Why?
Antibodies, Blocking220072500.080 Why?
Leukotrienes119902320.080 Why?
Chemokine CXCL12220144570.080 Why?
Endocytosis220129520.070 Why?
NF-kappa B6201224950.070 Why?
Stress, Mechanical5200816720.070 Why?
Immunologic Memory3200013770.070 Why?
Trypanosoma cruzi120102040.070 Why?
Antigens, Surface2198916170.070 Why?
Lentivirus Infections12007120.070 Why?
Antigens, Protozoan120103150.070 Why?
Models, Biological6200894580.070 Why?
Half-Life120086480.070 Why?
Mucoproteins12007490.070 Why?
Transcription Factors42014121470.070 Why?
Kruppel-Like Transcription Factors220075060.070 Why?
Quinolines120127690.070 Why?
Gap Junctions120082300.070 Why?
DNA Primers3200728240.070 Why?
Lipopolysaccharides3200722150.070 Why?
Cell Line82013155630.070 Why?
DNA-Binding Proteins2200196110.070 Why?
Mucins120105690.070 Why?
rho-Associated Kinases120082900.070 Why?
Transcription, Genetic4201476070.070 Why?
Interleukin-17120129230.060 Why?
Tunica Intima120084550.060 Why?
Antigens, Ly120072970.060 Why?
Cytokines7201174360.060 Why?
beta Catenin2200110470.060 Why?
Permeability120077280.060 Why?
Carcinoma1199623230.060 Why?
Receptors, Leukocyte-Adhesion32000530.060 Why?
Metalloendopeptidases219973860.060 Why?
Colonic Neoplasms1199625330.060 Why?
Thrombin420086000.060 Why?
Complement C5a120041000.060 Why?
Apolipoproteins B120063850.060 Why?
Reverse Transcriptase Polymerase Chain Reaction2201245660.060 Why?
Glycosylation1200711000.060 Why?
Colitis1201212410.060 Why?
Gastric Mucosa120076020.060 Why?
Chemokines, CX3C12003120.050 Why?
Carotid Arteries120089320.050 Why?
Tetradecanoylphorbol Acetate120048250.050 Why?
Chemokine CCL2220126040.050 Why?
Adenine Nucleotides219941110.050 Why?
Respiratory Mucosa120074370.050 Why?
Perfusion1200814090.050 Why?
Base Sequence62005124120.050 Why?
Vasculitis120075280.050 Why?
Platelet Glycoprotein GPIb-IX Complex120031440.050 Why?
Carcinogens120044520.050 Why?
Models, Cardiovascular120089770.050 Why?
Microcirculation1200712820.050 Why?
Sialyltransferases12002830.050 Why?
Toll-Like Receptor 4120065880.050 Why?
STAT4 Transcription Factor12001940.050 Why?
Vascular Endothelial Growth Factor A1201235080.050 Why?
Gene Knock-In Techniques220144190.050 Why?
Induced Pluripotent Stem Cells1201318830.050 Why?
Rabbits3199847520.050 Why?
Adaptor Proteins, Signal Transducing2201629000.050 Why?
Cardiovascular Diseases12007156390.050 Why?
Desmoplakins12001630.050 Why?
I-kappa B Proteins220062100.050 Why?
Immunohistochemistry32020110590.050 Why?
Anti-Glomerular Basement Membrane Disease12001410.050 Why?
Hyperglycemia1201013890.050 Why?
Rheology319993470.050 Why?
Interleukin-1beta1200710260.050 Why?
Lipoproteins120068710.050 Why?
Rats32013237180.050 Why?
Pulsatile Flow120013180.040 Why?
Mice, Inbred Strains1200317670.040 Why?
Female820213963540.040 Why?
Genetic Vectors2200134000.040 Why?
Ribonucleases120202660.040 Why?
alpha Catenin12000370.040 Why?
Diphtheria Toxin120202530.040 Why?
Nuclear Proteins1201457940.040 Why?
Hypercholesterolemia1200711450.040 Why?
Myocardial Infarction12020115010.040 Why?
N-Acetylneuraminic Acid219991740.040 Why?
U937 Cells120002590.040 Why?
Collagen1200826340.040 Why?
Antigen-Antibody Complex120015120.040 Why?
Blotting, Western1200750210.040 Why?
Cell Differentiation52020116480.040 Why?
CD8-Positive T-Lymphocytes2200646520.040 Why?
Lymphocytes3199926050.040 Why?
Basophils219924070.040 Why?
Selectins119991010.040 Why?
Amino Acid Sequence32006134100.040 Why?
Environment, Controlled11999420.040 Why?
Gene Transfer Techniques3199912060.040 Why?
Immunophenotyping2202018660.040 Why?
Luminescent Proteins120018390.040 Why?
Palatine Tonsil119991930.040 Why?
Oligosaccharides219994060.040 Why?
N-Formylmethionine Leucyl-Phenylalanine319932210.040 Why?
Myocarditis120068010.040 Why?
Mice, Mutant Strains1200117500.040 Why?
Glucose1201043390.040 Why?
Staphylococcus aureus1200614290.040 Why?
T-Lymphocytes, Regulatory1201131130.040 Why?
Mechanotransduction, Cellular220165390.040 Why?
Hydroxymethylglutaryl-CoA Reductase Inhibitors1201232490.040 Why?
Lymphokines120009240.030 Why?
RNA-Binding Proteins1200618850.030 Why?
Blood Platelets2200724650.030 Why?
Neuraminidase119971920.030 Why?
Sodium Salicylate11996180.030 Why?
Immunological Synapses12016580.030 Why?
Threonine119972720.030 Why?
Adenoviruses, Human119982570.030 Why?
Cell Migration Assays, Leukocyte1201580.030 Why?
Cell Separation3201117180.030 Why?
Glomerular Basement Membrane12015350.030 Why?
Acetylcysteine119972620.030 Why?
Immunity, Humoral120206080.030 Why?
Enzyme Inhibitors1200637210.030 Why?
Receptors, Fc120195370.030 Why?
Polysaccharides1200210200.030 Why?
Kinetics2200162850.030 Why?
Staining and Labeling1200010730.030 Why?
Organ Specificity1202019660.030 Why?
HEK293 Cells2201642700.030 Why?
Cell Death1202016760.030 Why?
Cell Cycle1200329250.030 Why?
Immunoglobulin Fc Fragments119972870.030 Why?
Chemokine CCL1912014370.030 Why?
SOXF Transcription Factors12014310.030 Why?
Up-Regulation2200141410.030 Why?
Cations, Divalent119941670.030 Why?
Receptors, CCR7120141050.030 Why?
Coculture Techniques1201813360.030 Why?
Hirudins119951790.030 Why?
Pyrimidines1200630470.030 Why?
Dermatitis, Contact120141340.030 Why?
Retinal Vessels120008620.030 Why?
Microspheres119977740.030 Why?
Polymerization120141540.030 Why?
Cattle3200738140.030 Why?
Proteasome Endopeptidase Complex2199713190.030 Why?
Diabetes Mellitus, Experimental1200011210.030 Why?
Structure-Activity Relationship3200330530.030 Why?
Venules119931610.030 Why?
Aorta3201220410.030 Why?
Protease Inhibitors119977500.030 Why?
Blood Circulation119942480.030 Why?
Neovascularization, Pathologic2201226290.030 Why?
Antibodies3200724210.030 Why?
Chemokine CCL712012300.030 Why?
Endosomes120155210.030 Why?
Peritonitis120153680.030 Why?
Gene Knockout Techniques120158000.030 Why?
Bacterial Proteins1200638330.030 Why?
Physical Stimulation119945140.030 Why?
Cell Polarity220106370.030 Why?
Azepines120143290.030 Why?
Peptide Fragments1200551290.030 Why?
Carcinoma, Lewis Lung120121060.030 Why?
Autocrine Communication120131670.020 Why?
Protein Kinase C2200712060.020 Why?
Antigen-Presenting Cells120159600.020 Why?
Receptors, Tumor Necrosis Factor, Type I120132580.020 Why?
Receptors, CXCR3120132410.020 Why?
Glomerular Mesangium11991980.020 Why?
Chemokine CCL2012012640.020 Why?
Chemokine CXCL10220063110.020 Why?
Acetylation1201410540.020 Why?
STAT1 Transcription Factor120133400.020 Why?
Kidney2201570710.020 Why?
Injections, Intravenous1199313770.020 Why?
Glycoproteins1199922010.020 Why?
Protein Multimerization120169600.020 Why?
Gene Expression Profiling1200795210.020 Why?
Eicosanoids219902840.020 Why?
Protein Isoforms2200817150.020 Why?
Regulatory Sequences, Nucleic Acid120147920.020 Why?
Diabetic Retinopathy1200012990.020 Why?
Adhesiveness12010520.020 Why?
Prostaglandins B1199050.020 Why?
Fluorescent Antibody Technique2199924700.020 Why?
Leukotriene A411990240.020 Why?
Fibroblasts1202041640.020 Why?
RNA Polymerase II120145490.020 Why?
Fura-2119901070.020 Why?
Spectrophotometry, Ultraviolet119901990.020 Why?
Phagocytes119912920.020 Why?
Vascular Endothelial Growth Factor Receptor-2120125470.020 Why?
Arachidonic Acids119902950.020 Why?
Receptors, CXCR4120147290.020 Why?
Hematopoietic Stem Cells1200234070.020 Why?
Dose-Response Relationship, Drug32010107400.020 Why?
Saphenous Vein120125190.020 Why?
Benzofurans119901390.020 Why?
Minor Histocompatibility Antigens120103030.020 Why?
Leukocyte Adherence Inhibition Test1198860.020 Why?
Triazoles120149020.020 Why?
Tumor Cells, Cultured1199661050.020 Why?
Dermatitis, Allergic Contact120101120.020 Why?
Neoplasm Transplantation1201220100.020 Why?
Leukotriene B4119902810.020 Why?
Cytosol119928860.020 Why?
Phenotype42013167210.020 Why?
Immunologic Techniques119882120.020 Why?
Molecular Sequence Data42006176050.020 Why?
Cell Membrane4200336400.020 Why?
Enhancer Elements, Genetic1201413630.020 Why?
Protein Structure, Tertiary1201437570.020 Why?
Spectrometry, Fluorescence119906940.020 Why?
Electrocardiography1202063780.020 Why?
Lipoxins119904190.020 Why?
Focal Adhesions120071130.020 Why?
Cell Line, Tumor22019170820.020 Why?
HLA Antigens1199213390.020 Why?
Reactive Oxygen Species1201521430.020 Why?
Type C Phospholipases120072870.020 Why?
Tumor Burden1201219000.020 Why?
Brain12013271560.020 Why?
Nuclear Receptor Coactivator 312006450.020 Why?
Cholesterol, VLDL12006700.020 Why?
Chromatography, High Pressure Liquid1199015280.020 Why?
Endotoxins119885190.020 Why?
Protein Kinase C-alpha120061120.020 Why?
Granulomatous Disease, Chronic119861750.020 Why?
Superoxides119863880.020 Why?
Th17 Cells120127880.020 Why?
Lipoproteins, VLDL120061980.020 Why?
Immunoglobulin G1199645590.010 Why?
Male620203639750.010 Why?
RNA, Messenger32011127880.010 Why?
Forkhead Transcription Factors1201116250.010 Why?
Histones1201425910.010 Why?
Myocytes, Smooth Muscle120087010.010 Why?
Leukemia, T-Cell120031020.010 Why?
Ethanol1199013240.010 Why?
DNA, Recombinant120034550.010 Why?
Chemokine CX3CL112003610.010 Why?
Peanut Agglutinin12002190.010 Why?
Lipoproteins, LDL120066420.010 Why?
Chromatin1201429790.010 Why?
Lymphocyte Subsets120033130.010 Why?
Glutathione Transferase120045650.010 Why?
Zinc Fingers120045770.010 Why?
Membrane Potentials3199210850.010 Why?
Myeloid Differentiation Factor 88120065820.010 Why?
Muscle, Smooth, Vascular1200814940.010 Why?
Sialoglycoproteins120023160.010 Why?
Macromolecular Substances1200314310.010 Why?
Nitric Oxide Synthase120049110.010 Why?
Nitric Oxide Synthase Type III120047070.010 Why?
Apolipoproteins E1200714590.010 Why?
Microvilli120012340.010 Why?
Chronic Disease1199693520.010 Why?
Acridine Orange12000280.010 Why?
Child, Preschool22020425760.010 Why?
Basement Membrane120013490.010 Why?
Bone Marrow Transplantation1200827300.010 Why?
Monokines11999710.010 Why?
GPI-Linked Proteins120014720.010 Why?
K562 Cells120016450.010 Why?
Rats, Long-Evans120003800.010 Why?
Dyslipidemias120068710.010 Why?
Gene Expression2200675830.010 Why?
Kidney Glomerulus120015710.010 Why?
Time Factors21996401160.010 Why?
Adenosine Triphosphate2199420020.010 Why?
Antigens, Differentiation, T-Lymphocyte119998970.010 Why?
Oligonucleotide Array Sequence Analysis1200437950.010 Why?
Aged220201712340.010 Why?
Stimulation, Chemical119953050.010 Why?
Transcription Factor RelB11995290.010 Why?
Leupeptins119951120.010 Why?
Epitopes2199125260.010 Why?
Child22020806680.010 Why?
Binding Sites1200360100.010 Why?
Polymerase Chain Reaction1200460610.010 Why?
Calpain119951460.010 Why?
Adenylyl Imidodiphosphate11994180.010 Why?
Computer Simulation1200862590.010 Why?
Thionucleotides119941070.010 Why?
Immunoglobulin M1199915270.010 Why?
Oligodeoxyribonucleotides119957050.010 Why?
Adenosine Diphosphate119944210.010 Why?
Biological Transport, Active119933230.010 Why?
Promoter Regions, Genetic1200457890.010 Why?
Adenoviridae1199610930.010 Why?
Autoantibodies1200121150.010 Why?
Viscosity119933340.010 Why?
Receptors, Very Late Antigen11992740.010 Why?
Biophysical Phenomena119933170.010 Why?
Hydrolysis119936450.010 Why?
Biophysics119933750.010 Why?
Epithelial Cells1200436890.010 Why?
Cytochalasin B11990740.010 Why?
Receptors, Interleukin-8A11990470.010 Why?
Osmolar Concentration119926550.010 Why?
Antigens, Neoplasm1199919980.010 Why?
Pancreatic Elastase119901240.010 Why?
Virulence Factors, Bordetella119901540.010 Why?
Pertussis Toxin119901760.010 Why?
Transcriptional Activation1199617490.010 Why?
Extracellular Space119925620.010 Why?
Cell Aggregation119902380.010 Why?
Receptors, Leukotriene B411990930.010 Why?
Cell Degranulation119902760.010 Why?
Apyrase119923760.010 Why?
Carbon Radioisotopes119905440.000 Why?
Immunoconjugates119959760.000 Why?
Cytochrome b Group11986590.000 Why?
Flavoproteins11986400.000 Why?
NADH, NADPH Oxidoreductases11986960.000 Why?
Culture Media119888930.000 Why?
Cell Compartmentation119863830.000 Why?
Aspergillosis119862420.000 Why?
Oxidation-Reduction1199022230.000 Why?
Vitamin B 12119865310.000 Why?
Peroxidase119866100.000 Why?
Young Adult12010599280.000 Why?
Hydrogen Peroxide119867410.000 Why?
Abscess119866050.000 Why?
Proto-Oncogene Proteins1199545210.000 Why?
Lipid Metabolism1199018960.000 Why?
Oxygen Consumption1198618700.000 Why?
Mutation12003302200.000 Why?
Pedigree1198645370.000 Why?
Aspirin1198831340.000 Why?
Adult120102232530.000 Why?
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.