Harvard Catalyst Profiles

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Maria Agustina Battistone, Ph.D.

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  1. R01HD104672 (BATTISTONE, MARIA AGUSTINA) Apr 1, 2021 - Mar 31, 2026
    NIH
    Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity.
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Barrachina F, Ottino K, Tu LJ, Soberman RJ, Brown D, Breton S, Battistone MA. CX3CR1 deficiency leads to impairment of immune surveillance in the epididymis. Cell Mol Life Sci. 2022 Dec 23; 80(1):15. PMID: 36550225; PMCID: PMC9948740.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Belardin LB, Brochu K, Légaré C, Battistone MA, Breton S. Purinergic signaling in the male reproductive tract. Front Endocrinol (Lausanne). 2022; 13:1049511. PMID: 36419764; PMCID: PMC9676935.
    Citations:    Fields:    Translation:Humans
  3. Barrachina F, Battistone MA, Castillo J, Mallofré C, Jodar M, Breton S, Oliva R. Sperm acquire epididymis-derived proteins through epididymosomes. Hum Reprod. 2022 04 01; 37(4):651-668. PMID: 35137089; PMCID: PMC8971652.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Breton S, Battistone MA. Unexpected Participation of Intercalated Cells in Renal Inflammation and Acute Kidney Injury. Nephron. 2022; 146(3):268-273. PMID: 34657041; PMCID: PMC9010481.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Tourzani DA, Battistone MA, Salicioni AM, Breton S, Visconti PE, Gervasi MG. Caput Ligation Renders Immature Mouse Sperm Motile and Capable to Undergo cAMP-Dependent Phosphorylation. Int J Mol Sci. 2021 Sep 23; 22(19). PMID: 34638585; PMCID: PMC8549708.
    Citations:    Fields:    Translation:AnimalsCells
  6. Mendelsohn AC, Sanmarco LM, Spallanzani RG, Brown D, Quintana FJ, Breton S, Battistone MA. From initial segment to cauda: a regional characterization of mouse epididymal CD11c+ mononuclear phagocytes based on immune phenotype and function. Am J Physiol Cell Physiol. 2020 12 01; 319(6):C997-C1010. PMID: 32991210; PMCID: PMC7792679.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Battistone MA, Mendelsohn AC, Spallanzani RG, Allegretti AS, Liberman RN, Sesma J, Kalim S, Wall SM, Bonventre JV, Lazarowski ER, Brown D, Breton S. Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice. J Clin Invest. 2020 07 01; 130(7):3734-3749. PMID: 32287042; PMCID: PMC7324186.
    Citations: 21     Fields:    Translation:AnimalsCells
  8. Battistone MA, Mendelsohn AC, Spallanzani RG, Brown D, Nair AV, Breton S. Region-specific transcriptomic and functional signatures of mononuclear phagocytes in the epididymis. Mol Hum Reprod. 2020 01 01; 26(1):14-29. PMID: 31778536; PMCID: PMC6992890.
    Citations: 9     Fields:    Translation:AnimalsCells
  9. Battistone MA, Spallanzani RG, Mendelsohn AC, Capen D, Nair AV, Brown D, Breton S. Novel role of proton-secreting epithelial cells in sperm maturation and mucosal immunity. J Cell Sci. 2019 11 18; 133(5). PMID: 31636115.
    Citations: 7     Fields:    Translation:AnimalsCells
  10. Breton S, Nair AV, Battistone MA. Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa. Andrology. 2019 09; 7(5):631-643. PMID: 31044554.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  11. Battistone MA, Merkulova M, Park YJ, Peralta MA, Gombar F, Brown D, Breton S. Unravelling purinergic regulation in the epididymis: activation of V-ATPase-dependent acidification by luminal ATP and adenosine. J Physiol. 2019 04; 597(7):1957-1973. PMID: 30746715; PMCID: PMC6441927.
    Citations: 8     Fields:    Translation:Animals
  12. Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA. Reply to Edemir: Physiological regulation and single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E351-E352. PMID: 29311339; PMCID: PMC5777009.
    Citations: 1     Fields:    Translation:Cells
  13. Battistone MA, Nair AV, Barton CR, Liberman RN, Peralta MA, Capen DE, Brown D, Breton S. Extracellular Adenosine Stimulates Vacuolar ATPase-Dependent Proton Secretion in Medullary Intercalated Cells. J Am Soc Nephrol. 2018 02; 29(2):545-556. PMID: 29222395; PMCID: PMC5791049.
    Citations: 12     Fields:    Translation:AnimalsCells
  14. Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA. Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9989-E9998. PMID: 29089413.
    Citations: 110     Fields:    Translation:AnimalsCells
  15. Park YJ, Battistone MA, Kim B, Breton S. Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis†. Biol Reprod. 2017 04 01; 96(4):937. PMID: 28371820; PMCID: PMC6322657.
    Citations: 3     Fields:    
  16. Park YJ, Battistone MA, Kim B, Breton S. Relative contribution of clear cells and principal cells to luminal pH in the mouse epididymis. Biol Reprod. 2017 02 01; 96(2):366-375. PMID: 28203710; PMCID: PMC6213081.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Alvau A, Battistone MA, Gervasi MG, Navarrete FA, Xu X, Sánchez-Cárdenas C, De la Vega-Beltran JL, Da Ros VG, Greer PA, Darszon A, Krapf D, Salicioni AM, Cuasnicu PS, Visconti PE. The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm. Development. 2016 07 01; 143(13):2325-33. PMID: 27226326.
    Citations: 31     Fields:    Translation:AnimalsCells
  18. Da Ros VG, Muñoz MW, Battistone MA, Brukman NG, Carvajal G, Curci L, Gómez-ElIas MD, Cohen DB, Cuasnicu PS. From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization. Asian J Androl. 2015 Sep-Oct; 17(5):711-5. PMID: 26112483; PMCID: PMC4577577.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  19. Vasen G, Battistone MA, Croci DO, Brukman NG, Weigel Muñoz M, Stupirski JC, Rabinovich GA, Cuasnicú PS. The galectin-1-glycan axis controls sperm fertilizing capacity by regulating sperm motility and membrane hyperpolarization. FASEB J. 2015 Oct; 29(10):4189-200. PMID: 26136479.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Battistone MA, Alvau A, Salicioni AM, Visconti PE, Da Ros VG, Cuasnicú PS. Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation. Mol Hum Reprod. 2014 Nov; 20(11):1054-66. PMID: 25180269.
    Citations: 11     Fields:    Translation:HumansCells
  21. Maldera JA, Weigel Muñoz M, Chirinos M, Busso D, G E Raffo F, Battistone MA, Blaquier JA, Larrea F, Cuasnicu PS. Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3. Mol Hum Reprod. 2014 Apr; 20(4):341-9. PMID: 24334245.
    Citations: 14     Fields:    Translation:HumansCells
  22. Battistone MA, Da Ros VG, Salicioni AM, Navarrete FA, Krapf D, Visconti PE, Cuasnicú PS. Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases. Mol Hum Reprod. 2013 Sep; 19(9):570-80. PMID: 23630234.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  23. Krapf D, Ruan YC, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE. cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit. Dev Biol. 2012 Sep 01; 369(1):43-53. PMID: 22750823.
    Citations: 31     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.