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Sanghun Lee, Ph.D.

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Alzheimer's disease (AD) is the most common neurodegenerative disease, and mutations in the Amyloid Precursor Proteins and Presenilins has been linked to familial forms of AD. I have been actively engaged in AD research for the last decade, and have made important contributions to the understanding of synaptic dysfunction and mitochondrial calcium dysregulation in AD pathogenesis. In addition to being an expert electrophysiologist in the neurophysiology field, I have also gained extensive knowledge of mouse genetics and expertise in behavioral paradigms for learning and memory of AD mouse models. My research has been performed on the physiological role of Presenilins, Nicastrin and Amyloid Precursor Proteins in the mouse adult brain, focusing on the hippocampal network, and found its essential roles in synaptic plasticity at hippocampal synapses.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee SH, Bolshakov VY, Shen J. Inactivation of Presenilin in inhibitory neurons results in decreased GABAergic responses and enhanced synaptic plasticity. Mol Brain. 2021 05 25; 14(1):85. PMID: 34034776.
    Citations:    Fields:    Translation:AnimalsCells
  2. Kim KR, Kim Y, Jeong HJ, Kang JS, Lee SH, Kim Y, Lee SH, Ho WK. Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation. Mol Brain. 2021 03 30; 14(1):62. PMID: 33785038.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Lee SH, Lutz D, Drexler D, Frotscher M, Shen J. Differential modulation of short-term plasticity at hippocampal mossy fiber and Schaffer collateral synapses by mitochondrial Ca2. PLoS One. 2020; 15(10):e0240610. PMID: 33049001.
    Citations:    Fields:    Translation:AnimalsCells
  4. Lee SH, Kang J, Ho A, Watanabe H, Bolshakov VY, Shen J. APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival. Neuron. 2020 11 25; 108(4):676-690.e8. PMID: 32891188.
    Citations: 14     Fields:    Translation:AnimalsCells
  5. Lee SH, Lutz D, Mossalam M, Bolshakov VY, Frotscher M, Shen J. Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway. Mol Neurodegener. 2017 06 15; 12(1):48. PMID: 28619096.
    Citations: 9     Fields:    Translation:AnimalsCells
  6. Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 2015 Mar 04; 85(5):967-81. PMID: 25741723.
    Citations: 113     Fields:    Translation:HumansAnimals
  7. Lee SH, Sharma M, Südhof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8973-8. PMID: 24889619.
    Citations: 18     Fields:    Translation:AnimalsCells
  8. Cho HJ, Lee HJ, Youn SW, Koh SJ, Won JY, Chung YJ, Cho HJ, Yoon CH, Lee SW, Lee EJ, Kwon YW, Lee HY, Lee SH, Ho WK, Park YB, Kim HS. Secondary sphere formation enhances the functionality of cardiac progenitor cells. Mol Ther. 2012 Sep; 20(9):1750-66. PMID: 22713697.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  9. Lee SH, Kim KR, Ryu SY, Son S, Hong HS, Mook-Jung I, Lee SH, Ho WK. Impaired short-term plasticity in mossy fiber synapses caused by mitochondrial dysfunction of dentate granule cells is the earliest synaptic deficit in a mouse model of Alzheimer's disease. J Neurosci. 2012 Apr 25; 32(17):5953-63. PMID: 22539855.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  10. Lee TH, Song SH, Kim KL, Yi JY, Shin GH, Kim JY, Kim J, Han YM, Lee SH, Lee SH, Shim SH, Suh W. Functional recapitulation of smooth muscle cells via induced pluripotent stem cells from human aortic smooth muscle cells. Circ Res. 2010 Jan 08; 106(1):120-8. PMID: 19959777.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  11. Lee SH, Ho WK, Lee SH. Characterization of somatic Ca2+ clearance mechanisms in young and mature hippocampal granule cells. Cell Calcium. 2009 May; 45(5):465-73. PMID: 19362367.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Jang J, Ku SY, Kim JE, Choi K, Kim YY, Kim HS, Oh SK, Lee EJ, Cho HJ, Song YH, Lee SH, Lee SH, Suh CS, Kim SH, Moon SY, Choi YM. Notch inhibition promotes human embryonic stem cell-derived cardiac mesoderm differentiation. Stem Cells. 2008 Nov; 26(11):2782-90. PMID: 18757302.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  13. Joo JY, Kim BW, Lee JS, Park JY, Kim S, Yun YJ, Lee SH, Lee SH, Rhim H, Son H. Activation of NMDA receptors increases proliferation and differentiation of hippocampal neural progenitor cells. J Cell Sci. 2007 Apr 15; 120(Pt 8):1358-70. PMID: 17389682.
    Citations: 35     Fields:    Translation:AnimalsCells
  14. Lee SH, Kim MH, Lee JY, Lee SH, Lee D, Park KH, Ho WK. Na+/Ca2+ exchange and Ca2+ homeostasis in axon terminals of mammalian central neurons. Ann N Y Acad Sci. 2007 Mar; 1099:396-412. PMID: 17446480.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Lee SH, Park KH, Ho WK, Lee SH. Postnatal developmental changes in Ca2+ homeostasis in supraoptic magnocellular neurons. Cell Calcium. 2007 May; 41(5):441-50. PMID: 17010427.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.