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Sanghun Lee, Ph.D.

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Alzheimer's disease (AD) is the most common neurodegenerative disease, and mutations in the Amyloid Precursor Proteins and Presenilins has been linked to familial forms of AD. I have been actively engaged in AD research for the last decade, and have made important contributions to the understanding of synaptic dysfunction and mitochondrial calcium dysregulation in AD pathogenesis. In addition to being an expert electrophysiologist in the neurophysiology field, I have also gained extensive knowledge of mouse genetics and expertise in behavioral paradigms for learning and memory of AD mouse models. My research has been performed on the physiological role of Presenilins, Nicastrin and Amyloid Precursor Proteins in the mouse adult brain, focusing on the hippocampal network, and found its essential roles in synaptic plasticity at hippocampal synapses.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.